valeriana officinalis
valerian
Identification
| Name | valeriana officinalis |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for valeriana officinalis usage levels up to | not for fragrance use. |
| Recommendation for valeriana officinalis flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
valerian
PubMed:
Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites.
PubMed:
Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis).
PubMed:
The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model.
PubMed:
Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial.
PubMed:
Valerian: no evidence for clinically relevant interactions.
PubMed:
Valeriana officinalis L. for conscious sedation of patients submitted to impacted lower third molar surgery: A randomized, double-blind, placebo-controlled split-mouth study.
PubMed:
The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats.
PubMed:
Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway.
PubMed:
Metabolic flux phenotype of tobacco hairy roots engineered for increased geraniol production.
PubMed:
Three new germacrane-type sesquiterpenes with NGF-potentiating activity from Valeriana officinalis var. latiofolia.
PubMed:
Phytotherapy against insomnia: extravagant claims or an alternative medicine?
PubMed:
Characterization of two geraniol synthases from Valeriana officinalis and Lippia dulcis: similar activity but difference in subcellular localization.
PubMed:
Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation.
PubMed:
Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster.
PubMed:
Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial.
PubMed:
Teratogenic risk perception and confidence in use of medicines in pairs of pregnant women and general practitioners based on patient information leaflets.
PubMed:
Adverse effects of herbal medicines: an overview of systematic reviews.
PubMed:
Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization.
PubMed:
Antioxidant effect and study of bioactive components of Valeriana sisymbriifolia and Nardostachys jatamansii in comparison to Valeriana officinalis.
PubMed:
Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis.
PubMed:
Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors.
PubMed:
Acylated iridoids from the roots of Valeriana officinalis var. latifolia.
PubMed:
Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis).
PubMed:
Phenotyping studies to assess the effects of phytopharmaceuticals on in vivo activity of main human cytochrome p450 enzymes.
PubMed:
Effects of valerian consumption during pregnancy on cortical volume and the levels of zinc and copper in the brain tissue of mouse fetus.
PubMed:
Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations.
PubMed:
Enhanced chromatographic fingerprinting of herb materials by multi-wavelength selection and chemometrics.
PubMed:
Sesquiterpenoids and lignans from the roots of Valeriana officinalis L.
PubMed:
Complementary and Alternative Drugs Use among Preoperative Patients: A Cross-Sectional Study in Italy.
PubMed:
Three phases hollow fiber LPME combined with HPLC-UV for extraction, preconcentration and determination of valerenic acid in Valeriana officinalis.
PubMed:
Volvalerelactones A and B, two new sesquiterpenoid lactones with an unprecedented skeleton from Valeriana officinalis var. latifolia.
PubMed:
Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes.
PubMed:
Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats.
PubMed:
The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5).
PubMed:
[Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies].
PubMed:
Evaluation of commercial essential oil samples on the growth of postharvest pathogen Monilinia fructicola (G. Winter) Honey.
PubMed:
Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study.
PubMed:
Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.
PubMed:
Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors.
PubMed:
Composition of essential oils in subterranean organs of three species of Valeriana L.
PubMed:
Pharmacokinetics of valerenic acid after single and multiple doses of valerian in older women.
PubMed:
Chemical analysis and biological activity of the essential oils of two valerianaceous species from China: Nardostachys chinensis and Valeriana officinalis.
PubMed:
Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia.
PubMed:
Treating primary insomnia - the efficacy of valerian and hops.
PubMed:
Patterns of self-medication with medicinal plants and related adverse events--a South American survey.
PubMed:
Phytotherapeutics: an evaluation of the potential of 1000 plants.
PubMed:
Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.
PubMed:
[Knowledge of perioperative risk associated with use of medicinal plants].
PubMed:
[Detection of viral infection pathogens in medicinal plants grown in Ukraine].
PubMed:
Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine.
PubMed:
Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.
PubMed:
Root colonization by symbiotic arbuscular mycorrhizal fungi increases sesquiterpenic acid concentrations in Valeriana officinalis L.
PubMed:
[HPLC fingerprint of the antiarrhythmic fraction of Valeriana officinalis].
PubMed:
Iridoids and sesquiterpenoids from the roots of Valeriana officinalis.
PubMed:
Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam.
PubMed:
Direct metabolic fingerprinting of commercial herbal tinctures by nuclear magnetic resonance spectroscopy and mass spectrometry.
PubMed:
Pinoresinol-4,4'-di-O-beta-D-glucoside from Valeriana officinalis root stimulates calcium mobilization and chemotactic migration of mouse embryo fibroblasts.
PubMed:
In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents.
PubMed:
Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle.
PubMed:
Total synthesis of valerenic acid, a potent GABAA receptor modulator.
PubMed:
A feasibility study of valerian extract for sleep disturbance in person with arthritis.
PubMed:
Preclinical toxicological assessment of a phytotherapeutic product--CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.).
PubMed:
Toxicological assessment of P-9801091 plant mixture extract after chronic administration in CBA/HZg mice--a biochemical and histological study.
PubMed:
Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier.
PubMed:
Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease.
PubMed:
A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia.
PubMed:
Analysis of the thrips fauna (Thysanoptera) on flowers of herbs.
PubMed:
Ethnophytotherapeutical research in the high Molise region (Central-Southern Italy).
PubMed:
[Studies on chemical constituents of Valeriana officinalis].
PubMed:
Essential oil composition of Valeriana officinalis L. roots cultivated in Iran. Comparative analysis between supercritical CO2 extraction and hydrodistillation.
PubMed:
Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties.
PubMed:
Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid.
PubMed:
Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
PubMed:
Valeriana officinalis does not alter the orofacial dyskinesia induced by haloperidol in rats: role of dopamine transporter.
PubMed:
Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A(1)- and GABA(A)-receptors.
PubMed:
Biological and analytical characterization of two extracts from Valeriana officinalis.
PubMed:
Identification of individual herbal drugs in tea mixtures using restriction analysis of ITS DNA and real-time PCR.
PubMed:
Valerian for sleep: a systematic review and meta-analysis.
PubMed:
Interaction of valerian extracts of different polarity with adenosine receptors: identification of isovaltrate as an inverse agonist at A1 receptors.
PubMed:
NF-kappaB modulators from Valeriana officinalis.
PubMed:
Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes.
PubMed:
Effects of aqueous, methanolic and chloroform extracts of rhizome and aerial parts of Valeriana officinalis L. on naloxone-induced jumping in morphine-dependent mice.
PubMed:
Authentication of Valeriana procera Kunth and comparative account of five Valeriana species.
PubMed:
Health effects of exposure to herb dust in valerian growing farmers.
PubMed:
Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress.
PubMed:
New acylated clionasterol glycosides from Valeriana officinalis.
PubMed:
Preserved pharmacological activity of hepatocytes-treated extracts of valerian and St. John's wort.
PubMed:
Exposure to airborne microorganisms, dust and endotoxin during processing of valerian roots on farms.
PubMed:
A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects.
PubMed:
Genotoxicity and anti-genotoxicity of some traditional medicinal herbs.
PubMed:
Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
PubMed:
In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes.
PubMed:
Determination of metal content in valerian root phytopharmaceutical derivatives by atomic spectrometry.
PubMed:
Monograph. Valeriana officinalis.
PubMed:
Extraction of valerenic acids from valerian (Valeriana officinalis L.) rhizomes.
PubMed:
In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4.
PubMed:
The use of valerian in neuropsychiatry.
PubMed:
Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers.
PubMed:
Neuroprotective properties of Valeriana officinalis extracts.
PubMed:
Effect of supplemental tryptophan, vitamin E, and a herbal product on responses by pigs to vibration.
PubMed:
Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans.
PubMed:
Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation.
PubMed:
Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers.
PubMed:
[Consumption of medicinal herbs in patients attending a gastroenterology outpatient clinic].
PubMed:
[Effects of Valeriana officinalis var. latifolia on expression of transforming growth factor beta 1 in hypercholesterolemic rats].
PubMed:
Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis.
PubMed:
Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
PubMed:
Mitogenic and comitogenic activities of polysaccharides from some European herbaceous plants.
PubMed:
A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.
PubMed:
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.
PubMed:
(-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis.
PubMed:
The importance of pharmacological synergy in psychoactive herbal medicines.
PubMed:
Analysis of sesquiterpenes in Valeriana officinalis by capillary electrophoresis.
PubMed:
Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia.
PubMed:
Synergy and other interactions in phytomedicines.
PubMed:
Ultrasound-assisted extraction of water-soluble polysaccharides from the roots of valerian (Valeriana officinalis L.).
PubMed:
Pacifigorgianes and tamariscene as constituents of Frullania tamarisci and Valeriana officinalis.
PubMed:
A1 adenosine receptors and their ligands: overview and recent developments.
PubMed:
Towards the industrial production of medicinal tincture by ultrasound assisted extraction.
PubMed:
Valeriana officinalis.
PubMed:
Influence of fibre coating in headspace solid-phase microextraction-gas chromatographic analysis of aromatic and medicinal plants.
PubMed:
[Interactions between herbal medicines and drugs].
PubMed:
Valerian for insomnia: a systematic review of randomized clinical trials.
PubMed:
Valerian: Valeriana officinalis.
PubMed:
Herbal medications for common ailments in the elderly.
PubMed:
Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H]GABA uptake, and hippocampal [3H]GABA release.
PubMed:
The relevance of herbal treatments for psychiatric practice.
PubMed:
Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system.
PubMed:
Hypericum perforatum inhibits the binding of mu- and kappa-opioid receptor expressed with the Semliki Forest virus system.
PubMed:
Seasonal variation of the essential oil, valerenic acid and derivatives, and velopotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines.
PubMed:
[Isolation and receptor binding properties of alkaloids and lignans from Valeriana officialis L].
PubMed:
Neurological stamp. Valeriana officinalis (garden heliotrope).
PubMed:
In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain.
PubMed:
[Clinical studies on the treatment of coronary heart disease with Valeriana officinalis var latifolia].
PubMed:
Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier.
PubMed:
Effects of a prolonged administration of valepotriates in rats on the mothers and their offspring.
PubMed:
High-yield production of valepotriates by hairy root cultures of Valeriana officnalis L. var. sambucifolia Mikan.
PubMed:
[Valeriana officinalis and Crataegus oxyacantha: toxicity from repeated administration and pharmacologic investigations].
PubMed:
[Saliunca].
PubMed:
Central nervous depressant activity of valerenic Acid in the mouse.
PubMed:
Valepotriate content in different in vitro cultures of Valerianaceae and characterization of Valeriana officinalis L. callus during a growth period.
PubMed:
Analysis of primary and secondary plant products in Valeriana officinalis callus during a growth cycle.
PubMed:
[Der Einfluss von Valerenal und Valerensäuren aus Valeriana officinalis auf die Aktivität von Ratten und den Dopamin-Metabolismus im Rattengehirn.]
PubMed:
Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man.
PubMed:
[Effects of Valeriana officinalis L extract on cardiovascular system].
PubMed:
Quantifying the effects of mild sedatives.
PubMed:
[Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them].
PubMed:
[Analytische und pharmakologische Aspekte des ätherischen Oles von Valeriana officinalis.]
PubMed:
Pharmacological screening of valerenal and some other components of essential oil of Valeriana officinalis.
PubMed:
[Composition of the flavonoids of Valeriana officinalis from the Asiatic part of the USSR].
PubMed:
[Chemical weed control in the cropping of medicinal plants. Part 1: Valerian (Valeriana officinalis L.) (author's transl)].
PubMed:
[Contribution to the study of valerian alcaloids (Valeriana officinalis, L.): actinidine and naphthyridylmethylketone, a new alkaloid (author's transl)].
PubMed:
[Flavonoid makeup of Valeriana officinalis from the southern and central provinces of the Ukraine].
PubMed:
[Active substances in Valeriana officinalis L].
PubMed:
New methods in the cultivation of Valeriana officinalis.
PubMed:
[Biosynthesis of alkaloids, valtrates and volatile oils in the roots of Valeriana officinalis L. from radioactive precursors].
PubMed:
[Permissible content of stalk residues in crude Valeriana officinalis].
PubMed:
[Pharmacological studies on the constituents of crude drugs and plants. 1. Pharmacological actions of Valeriana officinalis LinÅe var. latifolia Miquel].
PubMed:
[Dependence of the valepotriate and essential oil content in Valeriana officinalis L.s.l. on various exogenous and endogenous factors].
PubMed:
[Valeroside A--a glycoside from valerian (Valeriana officinalis L.)].
PubMed:
Isolation, structure and synthesis of alkaloids from Valeriana officinalis L.
PubMed:
[Tests of "industrial lyophilization" of medicinal plants. 3. Valeriana officinalis L. Influence of lyophilization on the quality of the drug].
PubMed:
[Comparative ethnomedical study of Valeriana officinalis L].
PubMed:
[Separation of alkaloids from the dried roots and rhizomes of Valeriana officinalis L].
PubMed:
Pharmacological investigation of certain Valeriana officinalis L. extracts.
PubMed:
Valeriana officinalis Linn., its polyploid forms and the structure of their rhizomes and roots.
PubMed:
[Yields in Valeriana officinalis cultivation].
PubMed:
[Method for differentiation of preparations of Centranthus ruber DC from Valeriana officinalis L; preliminary note].
PubMed:
[Cultivation of Valeriana officinalis].
PubMed:
[Studies on the quality and capacity of Valeriana officinalis].
PubMed:
[Studies on the modification of output and quality in Valeriana officinalis by growth technic and habitat].
PubMed:
[Experiments on fertilization of Atropa belladonna and Valeriana officinalis].