(1S,2R,5S,7R,8R)-2,6,6,8-tetramethyltricyclo[5.3.1.01,5]undecan-8-ol

CAS: 77-53-2 C15 H26 O MW: 222.37142000 woody woody

Identification

Namecedrol
IUPAC(1S,2R,5S,7R,8R)-2,6,6,8-tetramethyltricyclo[5.3.1.01,5]undecan-8-ol
CAS Number77-53-2
EINECS201-035-6
FDA UNII63ZM9703BO
Molecular FormulaC15 H26 O
Molecular Weight222.37142000
MDL NumberMFCD00062952
Nikkaji NumberJ499.451E
Beilstein2206347
CoE Number10190

Regulatory

JECFA Food Flavoring2030 (+)-cedrol
DG SANTE Food Flavourings02.120 (+)-cedrol
FEMA Number4503
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)77-53-2 ; (+)-CEDROL

Physical Properties

Appearance white to pale yellow crystalline solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 77.00 to 86.00 °C. @ 760.00 mm Hg
Boiling Point 285.00 to 287.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point 178.00 °F. TCC ( 81.11 °C. )
logP (o/w) 4.330
Soluble in alcohol
Similar Items note

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Strength low
Substantivity 400 hour(s) at 20.00 % in dipropylene glycol
Odor Description
at 100.00 %.
mild woody
cedarwood woody sweet soft
Cedarwood, Woody, Dry, Sweet, Soft
Characteristic cedar, sandalwood note, valuable addition to enhance woody facets in fine fragrances.
Odor sample from International Flavors & Fragrances Inc.
Taste Description
woody amber floral cedar ambrette musk powdery
soft woody, cedarwood-like
woody amber floral cedar ambrette musk powdery

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Human Experience8 % solution: no irritation or sensitization.
Oral/Parenteral Toxicityintraperitoneal-mouse LD > 500 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for cedrol usage levels up to50.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)13.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)3900 (μg/person/day)
Threshold of Concern1800 (μg/person/day)
Structure ClassI
baked goods10.00000
beverages(nonalcoholic)5.00000
beverages(alcoholic)5.00000
breakfast cereal5.00000
cheese7.00000
chewing gum-
condiments / relishes20.00000
confectionery froastings10.00000
egg products-
fats / oils5.00000
fish products2.00000
frozen dairy7.00000
fruit ices10.00000
gelatins / puddings10.00000
granulated sugar-
gravies5.00000
hard candy10.00000
imitation dairy7.00000
instant coffee / tea5.00000
jams / jellies7.00000
meat products2.00000
milk products7.00000
nut products5.00000
other grains5.00000
poultry2.00000
processed fruits7.00000
processed vegetables7.00000
reconstituted vegetables7.00000
seasonings / flavors5.00000
snack foods10.00000
soft candy10.00000
soups5.00000
sugar substitutes-
sweet sauces5.00000
Dairy products, excluding products of category 02.0 (01.0)7.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)5.00000
Edible ices, including sherbet and sorbet (03.0)10.00000
Processed fruit (04.1)7.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)10.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)5.00000
Bakery wares (07.0)10.00000
Meat and meat products, including poultry and game (08.0)2.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)2.00000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)5.00000
Foodstuffs intended for particular nutritional uses (13.0)10.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)5.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)10.00000
Ready-to-eat savouries (15.0)20.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)5.00000

ACS International GmbH

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Associate Allied Chemicals

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Augustus Oils Ltd

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Augustus Oils Ltd, in harmony with nature - to present it at its best...

View All Website +44 (0)1420 590555 essentials@augustus-oils.ltd.uk

Azelis UK Ltd.

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BOC Sciences

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Elan Inc.

Legacy of Innovation

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Fleurchem, Inc.

Have A Flavorful Day

A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.

View All Website 845-341-2100 info@fleurchem.com

Foreverest Resources Ltd.

Leading pine based chemicals supplier

Supplying turpentine based and natural/extracted flavor & fragrance ingredients.

View All Website +86 (0)592 5105533 info@foreverest.cn

Indukern, S.A. F&F Ingredients Division

Commitment to quality

Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.

View All Website +34 93 506 91 00 info@indukern.es

Lluch Essence S.L.

A family company dedicated to sales and distribution

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M&U International LLC

Steady supply & demand

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Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

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Penta International Corporation

Chemistry innovation

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PerfumersWorld Ltd.

feeeel... the smell!

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Prodasynth

PRODUCTEUR PAR ESSENCE

Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry.

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Robertet, Inc.

HOME OF NATURE, SEED TO SCENT

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Sigma-Aldrich

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SRS Aromatics Ltd

For over 25 years

Bringing flavour and fragrance into your world.

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TCI AMERICA

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We continuously strive to advance our technology.

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The John D. Walsh Company, Inc

Suppliers Since 1942

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The Lermond Company

Your Sourcing Resource

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R C Treatt and Co Ltd

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Ernesto Ventós S.A.

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Vigon International

Passion for Simplicity

Manufacturer and supplier of high quality flavor and fragrance ingredients.

View All Website 570-476-6300 sales@vigon.com

Potential Uses

FR acacia FR acorn FR almond FR alpine bouquet FR amber FR ambergris FR ambreine FL/FR angelica aphrodisiac FR armoise FR baby powder FR balsam FR bark FR bayberry FL/FR birch tar FR boronia FR bouquet FR boxwood FR boxwood blossom FR boxwood berry cabochard FR cade oil replacer FL/FR cajeput FR calamus oil replacer FR cardamom oil replacer FL/FR carrot seed FR castoreum FR cedar FR cedar FR cedarwood FR cigar FL/FR cistus FR citronella clean FR clove blossom FR costus FR country meadow FR cypress oil replacer FR date FR earth FR evergreen exotic FR fern FR fig FR fir balsam FR fir needle oil replacer fixer FR floral FR foliage FR ginger FL/FR guaiacwood FR hay new mown hay FR heather FR herbal FR hinoki oil replacer FR incense FR juniper FR juniper berry FR labdanum FR leather russian leather FR lemon liverwort FL/FR lovage root FR mango FR millefleurs FR moss FR musk FR niaouli FR opoponax FR oriental FR orris FR fresh outdoors FR patchouli FL/FR pepper tree berry FR pine FR pine forest FR pinion FR redwood FR root FR sage FR sandalwood FR sea breeze FR spice FR spikenard oil replacer FR spruce straw FR sweet grass timber FL/FR valerian FR vetiver FR violet wet fields FR windsor soap FR woodruff FR woody

Natural Occurrence

angelica seed oil CO2 extract @ 0.50% Data artemisia campestris spp. glutinosa flower oil italy @ 1.00% Data basil flower oil sweet @ 0.01% Data basil leaf oil sweet (ocimum basilicum) @ 0.02% Data calamus (european) - 1900 mg/kg cascarilla bark oil @ 0.07% Data cedarwood PMC cedarwood oil atlanta @ 10.40% Data cedarwood oil china @ 9.60% Data cedarwood oil texas @ 19.10% Data cedarwood oil virginia @ 22.20% Data cinnamon - up to 100 mg/kg PMC citronella oil zimbabwe @ 0.56% Data clary sage oil greece @ trace% Data cypress PMC cypress cone oil egypt @ 3.3% Data cypress oil @ 2.03-3.92% Data ginger rhizome oil ginger root oil CO2 extract @ 1.31% Data hinoki leaf oil @ 0.93% Data juniper branch oil @ 2.60% Data mayur pankh fruit oil himalaya @ 2.50% Data origanum PMC pepper black pepper fruit oil pepper black pepper seed oil peppermint oil rose oil otto bulgaria @ 0.07% Data wormwood oil annus france @ 0.00-trace% Data ylang ylang oil CO2 extract @ 0.02% Data

Synonyms

cedar camphor (8a)- cedran-8-ol (8R)- cedran-8-ol 8-betaH- cedran-8-ol 8betaH- cedran-8-ol 8bH- cedran-8-ol a- cedrol cedrol 35% natural cedrol 60% natural cedrol crystals cedrol crystals nat. cedrol crystals natural cedrol liquid (55-60% cedrol) cedrol powder natural cedrol prime (45-50% cedrol) cedrol redistilled texas cypress camphor 1H-3a,7- methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, (3R,3aS,6R,7R,8aS)- (3R-(3alpha,3abeta, 6alpha,7beta,8aalpha))- octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol (3R,3aS, 6R,7R,8aS)- octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol [3R-(3a,3ab,6a,7b,8aa)]- octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol [3R-(3a,3aβ,6a,7β,8aa)]- octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol (1S,2R,5R,7R,8R)-2,6,6,8- tetramethyltricyclo[5.3.1.0<1,5>]undecan-8-ol (1S,2R,5S,7R,8R)-2,6,6,8- tetramethyltricyclo[5.3.1.01,5]undecan-8-ol (1S,2R,5S,7R,8R)-2,6,6,8- tetramethyltricyclo[5.3.1.01.5]undecan-8-ol PubMed: Anticholinesterase and β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitory Compounds from the Heartwood of Juniperus chinensis. PubMed: Complete (1)H NMR assignment of cedranolides. PubMed: Discovery of an oviposition attractant for gravid malaria vectors of the Anopheles gambiae species complex. PubMed: Chemical Constituents from Sinningia canescens and S. warmingii. PubMed: Essential oil from the heartwood of Taiwan fir ameliorates LPS-induced inflammatory response by inhibiting the activation of mitogen-activated protein kinase. PubMed: Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. PubMed: Toxicity of hiba oil constituents and spray formulations to American house dust mites and copra mites. PubMed: Chemical composition and antimicrobial activity of the essential oil of Juniperus excelsa M.Bieb. growing wild in Lebanon. PubMed: Bioactivity of cedarwood oil and cedrol against arthropod pests. PubMed: Differential transcriptome analysis of glandular and filamentous trichomes in Artemisia annua. PubMed: Studies on the expression of linalool synthase using a promoter-β-glucuronidase fusion in transgenic Artemisia annua. PubMed: Studies on the expression of sesquiterpene synthases using promoter-β-glucuronidase fusions in transgenic Artemisia annua L. PubMed: Essential-oil composition of the Tunisian endemic cypress (Cupressus sempervirens L. var. numidica TRAB.). PubMed: Profiling of volatile compounds of Phyllostachys pubescens shoots in Taiwan. PubMed: Chemical constituents of volatile oil from Pyrolae herba and antiproliferative activity against SW1353 human chondrosarcoma cells. PubMed: Platelet-activating factor (PAF)-antagonists of natural origin. PubMed: Composition, anticancer, and antimicrobial activities in vitro of the heartwood essential oil of Cunninghamia lanceolata var. konishii from Taiwan. PubMed: The potential of Cyathus africanus for transformation of terpene substrates. PubMed: Structure based virtual screening of novel inhibitors against multidrug resistant superbugs. PubMed: Functional expression and characterization of sesquiterpene synthases from Artemisia annua L. using transient expression system in Nicotiana benthamiana. PubMed: [Analyze on chemical compositions of Dalbergia odorifera essential oils extracted by CO2-supercritical-fluid-extraction and steam distillation extraction]. PubMed: Chemical composition of volatile oils from the pericarps of Indian sandalwood (Santalum album) by different extraction methods. PubMed: [GC-MS analysis on volatile components of wild Trogopterus faeces from Laishui county of Hebei province]. PubMed: Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner. PubMed: Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects. PubMed: In vitro Na+/K+-ATPase inhibitory activity and antimicrobial activity of sesquiterpenes isolated from Thujopsis dolabrata. PubMed: Chiral recognition of diastereomeric 6-cedrols by vibrational circular dichroism. PubMed: Essential oils of Cupressus funebris, Juniperus communis, and J. chinensis (Cupressaceae) as repellents against ticks (Acari: Ixodidae) and mosquitoes (Diptera: Culicidae) and as toxicants against mosquitoes. PubMed: Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents. PubMed: Inhibitory effect of compounds from Goniothalamus tapis Miq. and Goniothalamus uvaroides King on platelet-activating factor receptor binding. PubMed: Chemical analysis of incense smokes used in Shaxi, Southwest China: a novel methodological approach in ethnobotany. PubMed: Volatile constituents, inorganic elements and primary screening of bioactivity of black coral cigarette holders. PubMed: Isolation, chemical, and biotransformation routes of labdane-type diterpenes. PubMed: Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. PubMed: Persistency assessment and aerobic biodegradation of selected cyclic sesquiterpenes present in essential oils. PubMed: An oxidative dearomatization-induced [5 + 2] cascade enabling the syntheses of α-cedrene, α-pipitzol, and sec-cedrenol. PubMed: Inhibitory effects of phylligenin and quebrachitol isolated from Mitrephora vulpina on platelet activating factor receptor binding and platelet aggregation. PubMed: Antiplatelet aggregation and platelet activating factor (PAF) receptor antagonistic activities of the essential oils of five Goniothalamus species. PubMed: Relation between developmental stage, sensory properties, and volatile content of organically and conventionally grown pac choi (Brassica rapa var. Mei Qing Choi). PubMed: Immunotoxicity activity of the major essential oils of Valeriana fauriei Briq against Aedes aegypti L. PubMed: Biotransformation of alpha-cedrol and caryophyllene oxide by the fungus Neurospora crassa. PubMed: [Electroantennogram responses of Maruca testulalis (Lepidoptera: Pyralidae) to plant volatiles and sex pheromone]. PubMed: Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods. PubMed: Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. PubMed: Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. PubMed: A new labdane-type diterpene from the bark of Juniperus chinensis Linn. PubMed: A gold-catalyzed entry into the sesquisabinene and sesquithujene families of terpenoids and formal total syntheses of cedrene and cedrol. PubMed: Fragrance material review on cedrol. PubMed: Woody pretzels: spirocycles from vetiver to patchouli and Georgywood. PubMed: Chemical composition and fungitoxic activity of essential oil of Thuja orientalis L. grown in the north-western Himalaya. PubMed: [Advances in sesquiterpene synthases cyclases of Artemisia annua]. PubMed: Effects of direct cedrol inhalation into the lower airway on autonomic nervous activity in totally laryngectomized subjects. PubMed: Antimicrobial activity of extractable conifer heartwood compounds toward Phytophthora ramorum. PubMed: Eudismic analysis of tricyclic sesquiterpenoid alcohols: lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7. PubMed: Overseas survey of the effect of cedrol on the autonomic nervous system in three countries. PubMed: Sesquiterpenes from the wood of Juniperus lucayana. PubMed: Chemical composition, cytotoxic activity and antimicrobial activity of essential oils of leaves and berries of Juniperus phoenicea L. grown in Egypt. PubMed: Biotransformation of terpenoids by mammals, microorganisms, and plant-cultured cells. PubMed: [Chemical components and antimicrobial activity of essential oils in Cunninghamia lanceolata heartwood]. PubMed: [Studies on the chemical constituents in root of Coleus forskohlii]. PubMed: Reduction of infectivity of schistosome cercariae by application of cercaricidal oil to water. PubMed: [Terpenoids in root exudates of different allelopathic rice varieties]. PubMed: Effect of magnesium on essential oil formation of genetically transformed and non-transformed chamomile cultures. PubMed: Intramolecular iron-mediated diene/olefin cyclocoupling: formation of carbon spirocycles. PubMed: Pressurized fluids for extraction of cedarwood oil from Juniperus virginianna. PubMed: New terpenoids in cultivated and wild chamomile (in vivo and in vitro). PubMed: Autonomic responses during inhalation of natural fragrance of Cedrol in humans. PubMed: Stereospecific hydroxylation of (+)-cedrol by using human skin microbial flora Staphylococcus epidermidis. PubMed: The sedative effects and mechanism of action of cedrol inhalation with behavioral pharmacological evaluation. PubMed: Crystal structure of 1beta-hydroxy-beta-homopipitzolone (9-hydroxy-2,6,9-trimethyltricyclo[6,3,1,0(1,6)]dodeca-5,10,11,12-tetraone). PubMed: Metabolic engineering to produce sesquiterpenes in yeast. PubMed: Volatile constituents of the fruit and leaf oils of Thuja orientalis L. grown in Iran. PubMed: [Analysis of chemical constituents in the essential oil from Evodia fargesii by GC/MS]. PubMed: Antimicrobial activity of some Pacific Northwest woods against anaerobic bacteria and yeast. PubMed: [Studies on the chemical components from Sargassum fusiform]. PubMed: Antitermitic activity of essential oils and components from Taiwania (Taiwania cryptomerioides). PubMed: Biotransformation of cedrol by Curvularia lunata ATCC 12017. PubMed: Potential antitermite compounds from Juniperus procera extracts. PubMed: Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L. PubMed: The molecular cloning of 8-epicedrol synthase from Artemisia annua. PubMed: Analysis of the essential oil of Juniperus procera Endl. growing in Kenya. PubMed: Isolation and characterization of platelet-activating factor receptor binding antagonists from Biota orientalis. PubMed: Phylogenetic influences in microbial hydroxylation of terpenoids. PubMed: Schistosoma mansoni: cercaricidal effects of cedarwood oil and various of its components. PubMed: GLC-mass spectrometry of Teucrium polium oil. PubMed: Exposure to an environment containing the aromatic red cedar, Juniperus virginiana: procarcinogenic, enzyme-inducing and insecticidal effects.