gynostemma pentaphyllum
twisting-vine orchid
Identification
| Name | gynostemma pentaphyllum |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for gynostemma pentaphyllum usage levels up to | not for fragrance use. |
| Recommendation for gynostemma pentaphyllum flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
twisting-vine
orchid
vitis pentaphylla
PubMed:
Metabolic profiling of Gynostemma pentaphyllum extract in rat serum, urine and faeces after oral administration.
PubMed:
Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats.
PubMed:
Determination by UPLC-MS of four dammarane-type saponins from heat-processed Gynostemma pentaphyllum.
PubMed:
Gypenoside attenuates hepatic ischemia/reperfusion injury in mice via anti-oxidative and anti-apoptotic bioactivities.
PubMed:
Protective effects of Gynostemma pentaphyllum polysaccharides on PC12 cells impaired by MPP(+).
PubMed:
Anticancer and immunoregulatory activity of Gynostemma pentaphyllum polysaccharides in H22 tumor-bearing mice.
PubMed:
Anti-cancer effect and the underlying mechanisms of gypenosides on human colorectal cancer SW-480 cells.
PubMed:
Effects of gypenosides on anxiety disorders in MPTP-lesioned mouse model of Parkinson's disease.
PubMed:
The Effect of Gynostemma pentaphyllum Extract on Mouse Dermal Fibroblasts.
PubMed:
Attenuation of Aβ25-35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathways.
PubMed:
Characterization of a novel alkali-soluble heteropolysaccharide from tetraploid Gynostemma pentaphyllum Makino and its potential anti-inflammatory and antioxidant properties.
PubMed:
[Molecular diversity of arbuscular mycorrhizal fungi in wild and cultured Gynostemma pentaphyllum roots in Xishuangbanna, Southwest China].
PubMed:
Cytotoxic activity of gypenosides and gynogenin against non-small cell lung carcinoma A549 cells.
PubMed:
Two novel anti-inflammatory 21-nordammarane saponins from tetraploid Jiaogulan ( Gynostemma pentaphyllum ).
PubMed:
Metabonomics study of the therapeutic mechanism of Gynostemma pentaphyllum and atorvastatin for hyperlipidemia in rats.
PubMed:
Arthrobacter gyeryongensis sp. nov., isolated from soil of a Gynostemma pentaphyllum field.
PubMed:
Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and α-glucosidase inhibitory activities.
PubMed:
Herbal medicines for fatty liver diseases.
PubMed:
Antiproliferation and anti-migration induced by gypenosides in human colon cancer SW620 and esophageal cancer Eca-109 cells.
PubMed:
Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial.
PubMed:
Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino.
PubMed:
Characterization of a novel polysaccharide from tetraploid Gynostemma pentaphyllum makino.
PubMed:
Anxiolytic effects of herbal ethanol extract from Gynostemma pentaphyllum in mice after exposure to chronic stress.
PubMed:
Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells.
PubMed:
[Experimental research on prevention and treatment of fatty liver rats with Abrus cantoniensis].
PubMed:
Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients.
PubMed:
Characterization of a heteropolysaccharide isolated from diploid Gynostemma pentaphyllum Makino.
PubMed:
Core-shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery.
PubMed:
Ombuin-3-O-β-D-glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors α and δ/β.
PubMed:
Chemical Composition of Three Polysaccharides From Gynostemma pentaphyllum and Their Antioxidant Activity in Skeletal Muscle of Exercised Mice.
PubMed:
Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins.
PubMed:
Chemical differentiation of two taste variants of Gynostemma pentaphyllum by using UPLC-Q-TOF-MS and HPLC-ELSD.
PubMed:
Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients.
PubMed:
Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells.
PubMed:
Two new triterpene saponins from Gynostemma pentaphyllum.
PubMed:
Chemical composition of three polysaccharides from Gynostemma pentaphyllum and their antioxidant activity in skeletal muscle of exercised mice.
PubMed:
Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats.
PubMed:
Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis.
PubMed:
Dammarane glycosides from the root of Machilus yaoshansis.
PubMed:
Isolation and antitumor activities of acidic polysaccharide from Gynostemma pentaphyllum Makino.
PubMed:
Restoration of electric footshock-induced immunosuppression in mice by Gynostemma pentaphyllum components.
PubMed:
Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide.
PubMed:
[Determination of arsenic, mercury and selenium in Gynostemma pentaphyllum and rhizospheric soil samples collected from different regions by hydride generation atomic fluorescence spectrometry].
PubMed:
Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase.
PubMed:
Preconditioning of brain slices against hypoxia induced injury by a Gynostemma pentaphyllum extract--stimulation of anti-oxidative enzyme expression.
PubMed:
Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract.
PubMed:
Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum.
PubMed:
New dammarane-type glycosides from the roots of Gynostemma pentaphyllum.
PubMed:
[Study of xiaozhang recipe combined with lamivudine in treatment of 84 chronic viral hepatitis B patients with compensated liver cirrhosis].
PubMed:
A new triterpenoid saponin from Gynostemma pentaphyllum.
PubMed:
New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum.
PubMed:
Antiproliferation effect and apoptosis mechanism of prostate cancer cell PC-3 by flavonoids and saponins prepared from Gynostemma pentaphyllum.
PubMed:
Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation.
PubMed:
Transcriptome profiling and insilico analysis of Gynostemma pentaphyllum using a next generation sequencer.
PubMed:
Antimicrobial activity of Gynostemma pentaphyllum extracts against fungi producing aflatoxin and fumonisin and bacteria causing diarrheal disease.
PubMed:
Gypenosides suppress growth of human oral cancer SAS cells in vitro and in a murine xenograft model: the role of apoptosis mediated by caspase-dependent and caspase-independent pathways.
PubMed:
Herbal extract of gynostemma pentaphyllum decreases hepatic glucose output in type 2 diabetic goto-kakizaki rats.
PubMed:
Microsatellite markers in the traditional Chinese medicinal herb Gynostemma pentaphyllum (Cucurbitaceae).
PubMed:
Dammarane-type saponins from Gynostemma pentaphyllum.
PubMed:
Chromatographic fingerprint analysis and rutin and quercetin compositions in the leaf and whole-plant samples of di- and tetraploid Gynostemma pentaphyllum.
PubMed:
Gypenoside TN-2 ameliorates scopolamine-induced learning deficit in mice.
PubMed:
Triterpenoid saponins from Gynostemma pentaphyllum.
PubMed:
Taxonomic significance of trichomes micromorphology in cucurbits.
PubMed:
Preparative chromatography of flavonoids and saponins in Gynostemma pentaphyllum and their antiproliferation effect on hepatoma cell.
PubMed:
Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome.
PubMed:
Preparation of carotenoids and chlorophylls from Gynostemma pentaphyllum (Thunb.) Makino and their antiproliferation effect on hepatoma cell.
PubMed:
Chemical composition of five commercial Gynostemma pentaphyllum samples and their radical scavenging, antiproliferative, and anti-inflammatory properties.
PubMed:
An experimental study on the antileukemia effects of gypenosides in vitro and in vivo.
PubMed:
Gypenosides protects dopaminergic neurons in primary culture against MPP(+)-induced oxidative injury.
PubMed:
Long-term oral administration of Gynostemma pentaphyllum extract attenuates airway inflammation and Th2 cell activities in ovalbumin-sensitized mice.
PubMed:
Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells.
PubMed:
Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways.
PubMed:
Dammarane saponins from Gynostemma pentaphyllum.
PubMed:
Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B.
PubMed:
Neuroprotective effects of herbal ethanol extracts from Gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
PubMed:
Dammarane-type saponins from Gynostemma pentaphyllum.
PubMed:
Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients.
PubMed:
Gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via Bax and Bcl-2 regulation.
PubMed:
Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract.
PubMed:
Dammarane-type glycosides from Gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells.
PubMed:
Gypenoside LXXIV ameliorates scopolamine-induced learning deficit in mice.
PubMed:
Gynostemosides A-E, megastigmane glycosides from Gynostemma pentaphyllum.
PubMed:
The inhibitory effect of Gynostemma pentaphyllum on MCP-1 and type I procollagen expression in rat hepatic stellate cells.
PubMed:
Screening of the hypoglycemic effect of eight Vietnamese herbal drugs.
PubMed:
[Fingerprints identification of Gynostemma pentaphyllum by RAPD and cloning and analysis of its specific DNA fragment].
PubMed:
Effect of Gynostemma Pentaphyllum polysaccharide on boar spermatozoa quality following freezing-thawing.
PubMed:
Protection of hippocampal slices against hypoxia/hypoglycemia injury by a Gynostemma pentaphyllum extract.
PubMed:
Protein tyrosine phosphatase 1B inhibitory by dammaranes from Vietnamese Giao-Co-Lam tea.
PubMed:
Polyploid origins in Gynostemma pentaphyllum (Cucurbitaceae) inferred from multiple gene sequences.
PubMed:
Potential hypoglycemic effect of an ethanol extract of Gynostemma pentaphyllum in C57BL/KsJ-db/db mice.
PubMed:
Immunomodulatory effects of cadmium and Gynostemma pentaphyllum herbal tea on rat splenocyte proliferation.
PubMed:
Determination of flavonoids and saponins in Gynostemma pentaphyllum (Thunb.) Makino by liquid chromatography-mass spectrometry.
PubMed:
Gypenosides induced G0/G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondria-dependent pathways in human tongue cancer SCC-4 cells.
PubMed:
Isolation and characterization of immunostimulatory polysaccharide from an herb tea, Gynostemma pentaphyllum Makino.
PubMed:
Determination of chlorophylls and their derivatives in Gynostemma pentaphyllum Makino by liquid chromatography-mass spectrometry.
PubMed:
Gynostemma pentaphyllum decreases allergic reactions in a murine asthmatic model.
PubMed:
Gypenosides inhibited invasion and migration of human tongue cancer SCC4 cells through down-regulation of NFkappaB and matrix metalloproteinase-9.
PubMed:
Gypenosides induced G0/G1 arrest via inhibition of cyclin E and induction of apoptosis via activation of caspases-3 and -9 in human lung cancer A-549 cells.
PubMed:
[The effect of Gynostemma pentaphyllum (GP) on plasma lipoprotein metabolism and lipoperoxidation lipoprotein in the experimental hyperglycemia rats].
PubMed:
The molecular mechanism of gypenosides-induced G1 growth arrest of rat hepatic stellate cells.
PubMed:
Method development for gypenosides fingerprint by high performance liquid chromatography with diode-array detection and the addition of internal standard.
PubMed:
[Influence of FPS on the expression of LDL-R mRNA in the liver tissues of hyperlipidemic rats].
PubMed:
[Studies on the HPLC fingerprint spectrum of flavonoids in Gynostemma pentaphyllum].
PubMed:
Specific reversal of multidrug resistance to colchicine in CEM/VLB(100) cells by Gynostemma pentaphyllum extract.
PubMed:
Determination of the three-dimensional structure of Gynoside A in solution using NMR and molecular modeling.
PubMed:
Gypenosides inhibited N-acetylation of 2-aminofluorene, N-acetyltransferase gene expression and DNA adduct formation in human cervix epithelioid carcinoma cells (HeLa).
PubMed:
Extract of Gynostemma pentaphyllum enhanced the production of antibodies and cytokines in mice.
PubMed:
Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells.
PubMed:
Phytopreventative effects of Gynostemma pentaphyllum against acute Indomethacin-induced gastrointestinal and renal toxicity in rats.
PubMed:
The possible mechanisms by which phanoside stimulates insulin secretion from rat islets.
PubMed:
Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat.
PubMed:
Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3.
PubMed:
Nine new dammarane saponins from Gynostemma pentaphyllum.
PubMed:
Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells.
PubMed:
[Simultaneous determination of total flavone and total saponin in Gynostemma pentaphyllum by signal multiplier spectrophotometry].
PubMed:
[The extraction, purification and assaying of Gynostemma pentaphyllum polysaccharides].
PubMed:
Determination of trace elements in herbal tea products and their infusions consumed in Thailand.
PubMed:
Management of SAH with traditional Chinese medicine in China.
PubMed:
The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease.
PubMed:
Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway.
PubMed:
Phytopreventative anti-hyperlipidemic effects of gynostemma pentaphyllum in rats.
PubMed:
Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice.
PubMed:
Three dammarane-type saponins from Gynostemma pentaphyllum.
PubMed:
Cardiovascular effects of the aqueous extract of Gynostemma pentaphyllum Makino.
PubMed:
Antimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extract.
PubMed:
Hairy root cultures of Gynostemma pentaphyllum (Thunb.) Makino: a promising approach for the production of gypenosides as an alternative of ginseng saponins.
PubMed:
A novel LXR-alpha activator identified from the natural product Gynostemma pentaphyllum.
PubMed:
Bronchodilatory effects of the aqueous extract of Gynostemma pentaphyllum and gypenosides III and VIII in anaesthetized guinea-pigs.
PubMed:
[Histochemical localization of ginsenosides in Gynostemma pentaphyllum and the content changes of total gypenosides].
PubMed:
[Study on spectral properties of Chinese herbal medicines additives in cosmetic].
PubMed:
[The analysis of Gynostemma pentaphyllum (Thunb) Makino for Chinese crude drug by FTIR and FT-Raman].
PubMed:
[Photosynthetic characteristics of Gynostemma pentaphyllum under shade].
PubMed:
[Composition analysis and dominance test of three kinds of raw variety of Gynostemma pentaphyllum].
PubMed:
Novel dammarane-type glycosides from Gynostemma pentaphyllum.
PubMed:
[Studies on sex identification and variation of endogenous hormones in female and male plants of Gynostemma pentaphyllum].
PubMed:
Chronic toxicity of Gynostemma pentaphyllum.
PubMed:
[Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism].
PubMed:
The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino.
PubMed:
Five new Ocotillone-type saponins from Gynostemma pentaphyllum.
PubMed:
A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum.
PubMed:
Dammarane-type glycosides from Gynostemma pentaphyllum.
PubMed:
[Determination of six nutritional elements in Chinese herbal medicines by graphite furnace atomic absorption spectrometry].
PubMed:
[Light environment characteristics of forest gap in deciduous broad-leaved forest and its effects on growth features of Gynostemma pentaphyllum in Jianghuai watershed].
PubMed:
Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-kappaB-mediated iNOS protein expression.
PubMed:
[Comparison of total saponin content in three wild species of Gynostemma on Mount Emei].
PubMed:
[Scavenging effects of Astragalus and Gynostemma pentaphyllum with its product on O2-. and .OH].
PubMed:
Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells.
PubMed:
[Dynamic features of some biochemical constituents in Gynostemma pentaphyllum under different environments].
PubMed:
Inhibitory effects of gynostemma pentaphyllum on the UV induction of bacteriophage lambda in lysogenic Escherichia coli.
PubMed:
Effect of gynostemma pentaphyllum mak on carcinomatous conversions of golden hamster cheek pouches induced by dimethylbenzanthracene: a histological study.
PubMed:
Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats.
PubMed:
Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum.
PubMed:
Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells.
PubMed:
The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum.
PubMed:
Gynostemma pentaphyllum: identification of major sapogenins and differentiation from Panax species.
PubMed:
[Determination on the glycosyl sequence of gypenoside A by TLC-FABMS].
PubMed:
[The study of influencing cellular dynamics of gynostemma pentaphyllum on golden hamster cheek pouch premalignancy]
PubMed:
New triterpenoid saponins from Gynostemma pentaphyllum.
PubMed:
[The effect of Gynostemma pentaphyllum mak (GP) on carcinogenesis of the golden hamster cheek pouch induced by DMBA].
PubMed:
[Observation of the effectiveness of compound Gynostemma Pentaphyllum Mak in golden hamster cheek pouch's premalignancy]
PubMed:
Protective effects of Gynostemma pentaphyllum in gamma-irradiated mice.
PubMed:
[A preliminary observation of preventive and blocking effect of Gynostemma pentaphyllum (Thunb) Makino on esophageal cancer in rats].
PubMed:
New dammarane-type glycosides from Gynostemma pentaphyllum.
PubMed:
[Effects of 24 Chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cell].
PubMed:
Protoplast culture and plant regeneration from the suspension cells of Gynostemma pentaphyllum (Thumb) Mak.
PubMed:
[Systematic concept and development model for the production base of Gynostemma pentaphyllum (Thunb.) Madino].
PubMed:
[Agronomic standardization of Gynostemma pentaphyllum (Thunb.) Makino].
PubMed:
[Intercropping techniques for Gynostemma pentaphyllum (Thunb.) Makino].
PubMed:
[Semi-culture techniques for Gynostemma pentaphyllum (Thunb.) Makino].
PubMed:
[Antithrombotic effect of Gynostemma pentaphyllum].
PubMed:
Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats.
PubMed:
Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes.
PubMed:
[Introduction and cultivation of Gynostemma pentaphyllum Mark. in Beijing].
PubMed:
Effects of gynostemma pentaphyllum makino on the immunological function of cancer patients.
PubMed:
[Spectrophotometric determination of micro-amounts of zinc in Gynostemma pentaphyllum (Thunb.) Makino].
PubMed:
[Isolation and identification of flavonoids and organic acids from Gynostemma pentaphyllum Makino].
PubMed:
[Clonal propagation of Gynostemma pentaphyllum (Thumb.) Makino in test tubes].
PubMed:
[A comparative identification of four Gynostemma spp. herbs and their various species from Guangxi].
PubMed:
[Rapid propagation of Gynostemma pentaphyllum Makino via tissue culture].
PubMed:
A new platelet aggregation factor from Gynostemma pentaphyllum Makino.