inonotus obliquus
chaga mushroom
Identification
| Name | inonotus obliquus |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for inonotus obliquus usage levels up to | not for fragrance use. |
| Recommendation for inonotus obliquus flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
chaga
mushroom
PubMed:
Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9.
PubMed:
CARI III inhibits tumor growth in a melanoma-bearing mouse model through induction of G0/G1 cell cycle arrest.
PubMed:
Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells.
PubMed:
[Prevention of Inonotus obliquus polysaccharides for high power microwave radiation induced testicular injury in rats: an experimental research].
PubMed:
Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats.
PubMed:
[A study of the antiherpetic activity of the chaga mushroom (Inonotus obliquus) extracts in the Vero cells infected with the herpes simplex virus].
PubMed:
Stimulated production of steroids in Inonotus obliquus by host factors from birch.
PubMed:
Inhibitory effects of a polysaccharide extract from the Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), on the proliferation of human neurogliocytoma cells.
PubMed:
Production of bioactive polysaccharides by Inonotus obliquus under submerged fermentation supplemented with lignocellulosic biomass and their antioxidant activity.
PubMed:
Polysaccharides from Inonotus obliquus sclerotia and cultured mycelia stimulate cytokine production of human peripheral blood mononuclear cells in vitro and their chemical characterization.
PubMed:
Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells.
PubMed:
Medicinal plants of the Russian Pharmacopoeia; their history and applications.
PubMed:
Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-κB signaling pathway.
PubMed:
Insulin-sensitizing and beneficial lipid-metabolic effects of the water-soluble melanin complex extracted from Inonotus obliquus.
PubMed:
Mycosynthesis: antibacterial, antioxidant and antiproliferative activities of silver nanoparticles synthesized from Inonotus obliquus (Chaga mushroom) extract.
PubMed:
Chemical constituents from Inonotus obliquus and their biological activities.
PubMed:
Chemical analysis and antioxidant activity of polysaccharides extracted from Inonotus obliquus sclerotia.
PubMed:
3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway.
PubMed:
Anti-oxidant and anti-inflammatory activities of Inonotus obliquus and germinated brown rice extracts.
PubMed:
Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation.
PubMed:
Progress on understanding the anticancer mechanisms of medicinal mushroom: inonotus obliquus.
PubMed:
Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus.
PubMed:
Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.
PubMed:
Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion.
PubMed:
Chemical properties and antioxidant activity of exopolysaccharides fractions from mycelial culture of Inonotus obliquus in a ground corn stover medium.
PubMed:
Stimulatory effect of different lignocellulosic materials for phenolic compound production and antioxidant activity from Inonotus obliquus in submerged fermentation.
PubMed:
Bioassay-guided isolation of DPP-4 inhibitory fractions from extracts of submerged cultured of Inonotus obliquus.
PubMed:
[Protective activity of aqueous extracts from higher mushrooms against Herpes simplex virus type-2 on albino mice model].
PubMed:
Physical modifications of polysaccharide from Inonotus obliquus and the antioxidant properties.
PubMed:
Lanostanoids from fungi: a group of potential anticancer compounds.
PubMed:
Antioxidative Properties of Crude Polysaccharides from Inonotus obliquus.
PubMed:
Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.
PubMed:
Orally administered aqueous extract of Inonotus obliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice.
PubMed:
[Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4].
PubMed:
Chemical modification and antioxidant activities of polysaccharide from mushroom Inonotus obliquus.
PubMed:
Antioxidant activities of five polysaccharides from Inonotus obliquus.
PubMed:
Inonotus obliquus containing diet enhances the innate immune mechanism and disease resistance in olive flounder Paralichythys olivaceus against Uronema marinum.
PubMed:
Antiviral activity of Inonotus obliquus fungus extract towards infection caused by hepatitis C virus in cell cultures.
PubMed:
Preparation of Chaga medicinal mushroom, Inonotus obliquus-fermented rice using solid-state fermentation and its taste quality and antioxidant property.
PubMed:
Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms.
PubMed:
Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies.
PubMed:
In vitro antitumor activity and structure characterization of ethanol extracts from wild and cultivated Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae).
PubMed:
Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice.
PubMed:
[Protective effects and mechanism of Inonotus obliquus on asthmatic mice].
PubMed:
Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus - a medicinal mushroom.
PubMed:
Changes of ginsenoside content by mushroom mycelial fermentation in red ginseng extract.
PubMed:
Involvements of S-nitrosylation and denitrosylation in the production of polyphenols by Inonotus obliquus.
PubMed:
Comparison of hypoglycemic activity of fermented mushroom of Inonotus obliquus rich in vanadium and wild-growing I. obliquus.
PubMed:
Rapid isolation and purification of inotodiol and trametenolic acid from Inonotus obliquus by high-speed counter-current chromatography with evaporative light scatting detection.
PubMed:
Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549.
PubMed:
Inonotus obliquus protects against oxidative stress-induced apoptosis and premature senescence.
PubMed:
Analysis of antioxidant metabolites by solvent extraction from sclerotia of Inonotus obliquus (Chaga).
PubMed:
Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus.
PubMed:
Extract of Chaga mushroom (Inonotus obliquus) stimulates 3T3-L1 adipocyte differentiation.
PubMed:
Production of antioxidant and antitumor metabolites by submerged cultures of Inonotus obliquus cocultured with Phellinus punctatus.
PubMed:
An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus.
PubMed:
Separation of an aqueous extract Inonotus obliquus (Chaga). A novel look at the efficiency of its influence on proliferation of A549 human lung carcinoma cells.
PubMed:
Enhancement of exo-polysaccharide production and antioxidant activity in submerged cultures of Inonotus obliquus by lignocellulose decomposition.
PubMed:
Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells.
PubMed:
Effects of ultrasonic treatment on the physicochemical properties and DPPH radical scavenging activity of polysaccharides from mushroom Inonotus obliquus.
PubMed:
Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production.
PubMed:
Optimization of hydroxyl radical scavenging activity of exo-polysaccharides from Inonotus obliquus in submerged fermentation using response surface methodology.
PubMed:
Beneficial effects of the ethanol extract from the dry matter of a culture broth of Inonotus obliquus in submerged culture on the antioxidant defence system and regeneration of pancreatic beta-cells in experimental diabetes in mice.
PubMed:
Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus.
PubMed:
Quantitative determination of steroids in the fruiting bodies and submerged-cultured mycelia of Inonotus obliquus.
PubMed:
Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate.
PubMed:
Optimization of ultrasonic/microwave assisted extraction (UMAE) of polysaccharides from Inonotus obliquus and evaluation of its anti-tumor activities.
PubMed:
Gamma-irradiation improves the color and antioxidant properties of Chaga mushroom (Inonotus obliquus) extract.
PubMed:
Prevention of hydrogen peroxide-induced oxidative stress in PC12 cells by 3,4-dihydroxybenzalacetone isolated from Chaga (Inonotus obliquus (persoon) Pilat).
PubMed:
Cancer cell cytotoxicity of extracts and small phenolic compounds from Chaga [Inonotus obliquus (persoon) Pilat].
PubMed:
Antioxidant activities of extracts and subfractions from Inonotus Obliquus.
PubMed:
Anti-inflammatory effect of Inonotus obliquus, Polygala senega L., and Viburnum trilobum in a cell screening assay.
PubMed:
Nitric oxide mediates the fungal-elicitor-enhanced biosynthesis of antioxidant polyphenols in submerged cultures of Inonotus obliquus.
PubMed:
Cytostatic activity of peptide extracts of medicinal plants on transformed A549, H1299, and HeLa Cells.
PubMed:
NMR-based metabonomic analysis on effect of light on production of antioxidant phenolic compounds in submerged cultures of Inonotus obliquus.
PubMed:
Progress of research on Inonotus obliquus.
PubMed:
Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells.
PubMed:
[Antitumor activity of the plant remedy peptide extract PE-PM in a new mouse T-lymphoma/eukemia model].
PubMed:
Oxidative stress response of Inonotus obliquus induced by hydrogen peroxide.
PubMed:
Comparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Inonotus obliquus.
PubMed:
Evaluation of antitumor activity of peptide extracts from medicinal plants on the model of transplanted breast cancer in CBRB-Rb(8.17)1Iem mice.
PubMed:
Potential anticancer properties of the water extract of Inonotus [corrected] obliquus by induction of apoptosis in melanoma B16-F10 cells.
PubMed:
Introduction to Distribution and Ecology of Sterile Conks of Inonotus obliquus.
PubMed:
Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis.
PubMed:
Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract.
PubMed:
Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus.
PubMed:
Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides.
PubMed:
Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice.
PubMed:
Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity.
PubMed:
Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells.
PubMed:
Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB.
PubMed:
New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus.
PubMed:
Sterol composition in field-grown and cultured mycelia of Inonotus obliquus.
PubMed:
Anti-complementary Activities of Exo- and Endo-biopolymer Produced by Submerged Mycelial Culture of Eight Different Mushrooms.
PubMed:
Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga).
PubMed:
Ethanol extract of Inonotus obliquus inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells.
PubMed:
Analysis of aqueous extract of Inonotus obliquus.
PubMed:
Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
PubMed:
Reversal of the TPA-induced inhibition of gap junctional intercellular communication by Chaga mushroom (Inonotus obliquus) extracts: effects on MAP kinases.
PubMed:
Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus.
PubMed:
Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus.
PubMed:
Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus.
PubMed:
Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus.
PubMed:
In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus.
PubMed:
Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay.
PubMed:
Antioxidant effect of Inonotus obliquus.
PubMed:
Cellular and physiological effects of Ganoderma lucidum (Reishi).
PubMed:
Biologically active compounds from Aphyllophorales (polypore) fungi.
PubMed:
[Effect of cryosubstance Chagi on deposition or isolation of 90Sr and on the effect of prolonged external exposure to gamma-radiation].
PubMed:
[The nature of melanin pigments from some micro- and macromycetes].
PubMed:
[Physicochemical properties of melanins produced by Inonotus obliquus("chagi") in the nature and the cultivated fungus].
PubMed:
[Melanin complex of the fungus Inonotus obliquus].
PubMed:
[Effects of bioglycans from birch fungus Inonotus obliquus on the electrical activity of cells from the cardiac venous sinus of the frog].
PubMed:
Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective.
PubMed:
The effect of aqueous extracts from Inonotus obliquus on the mitotic index and enzyme activities.
PubMed:
Effect of six species of white-rot basidiomycetes on the chemical composition and rumen degradability of wheat straw.
PubMed:
The substances of plant origin that inhibit protein biosynthesis.
PubMed:
Antimitotic activity of aqueous extracts of Inonotus obliquus.
PubMed:
Fungi in Khanty folk medicine.
PubMed:
Effect of the extracts from fungus Inonotus obliquus on catalase level in HeLa and nocardia cells.
PubMed:
Antitumor Activity of Triterpenes in Inonotus obliquus.
PubMed:
Experiments on Cultures of Inonotus obliquus.
PubMed:
3beta, 22-Dihydroxylanosta-7,9(11), 24-triene: A New, Minor Compound from Inonotus obliquus.
PubMed:
3beta-Hydroxy-lanosta-8,24-dien-21-al, a New Triterpene from Inontus obliquus.
PubMed:
[Aqueous extracts of Inonotus obliquus vel. Poria obliqua in the diagnosis of leukemias].
PubMed:
[Conditions for the formation of a pigment complex in Inonotus obliquus in artificial culture].
PubMed:
[Nature and origin of water-soluble pigment complex formed by Inonotus obliquus].
PubMed:
[Pharmacological and biological characteristics of Inonotus obliquus].