Identification

Namehops beta acids

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 63

Physical Properties

Appearance white to pale yellow powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantimicrobial agents
Recommendation for hops beta acids usage levels up tonot for fragrance use.
Recommendation for hops beta acids flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

hop

Synonyms

hops beta acids PubMed: Inhibition of fructan-fermenting equine faecal bacteria and Streptococcus bovis by hops (Humulus lupulus L.) β-acid. PubMed: Quantitative genetic parameters for yield, plant growth and cone chemical traits in hop (Humulus lupulus L.). PubMed: In vitro and in vivo antioxidant and antimutagenic activities of polyphenols extracted from hops (Humulus lupulus L.). PubMed: Hexahydro-β-acids potently inhibit 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice. PubMed: Metabolism of hop-derived bitter acids. PubMed: Beer and beer compounds: physiological effects on skin health. PubMed: Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. PubMed: Comparative proteomic profiling in compatible and incompatible interactions between hop roots and Verticillium albo-atrum. PubMed: Empiric mathematical model for predicting the content of alpha-acids in hop (Humulus lupulus L.) cv. Aurora. PubMed: Isoprene synthase genes form a monophyletic clade of acyclic terpene synthases in the TPS-B terpene synthase family. PubMed: Effects of extracts of Humulus lupulus (hops) and Yucca schidigera applied alone or in combination with monensin on rumen fermentation and microbial populations in vitro. PubMed: Identification and quantification of the oxidation products derived from α-acids and β-acids during storage of hops ( Humulus lupulus L.). PubMed: Comparative analysis of production and purification of homo- and hetero-polysaccharides produced by lactic acid bacteria. PubMed: On the reaction of lupulones, hops β-acids, with 1-hydroxyethyl radical. PubMed: Hop bitter acids inhibit tumorigenicity of hepatocellular carcinoma cells in vitro. PubMed: The effects of beta acids from hops (Humulus lupulus) on mortality of Varroa destructor (Acari: Varroidae). PubMed: Effects of hop varieties on ruminal fermentation and bacterial community in an artificial rumen (rusitec). PubMed: Isolation of bitter acids from hops (Humulus lupulus L.) using countercurrent chromatography. PubMed: HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops. PubMed: Flavonoid production in transgenic hop (Humulus lupulus L.) altered by PAP1/MYB75 from Arabidopsis thaliana L. PubMed: Survival of Escherichia coli O157:H7 in meat product brines containing antimicrobials. PubMed: LC determination of luteolin-7-O-β-D-glucoside and apigenin-7-O-β-D-glucoside in rat plasma after administration of Humulus scandens extract and its application to pharmacokinetic studies. PubMed: Occurrence of odorant polyfunctional thiols in the Super Alpha Tomahawk hop cultivar. Comparison with the thiol-rich Nelson Sauvin bitter variety. PubMed: High-performance liquid chromatographic determination and pharmacokinetic study of apigenin-7-O-β-D-glucoside in rat plasma after intravenous administration. PubMed: Chicken intestine microbiota following the administration of lupulone, a hop-based antimicrobial. PubMed: Application of plant-based antimicrobials for the growth inhibition of clostridia in pressed beet pulp silage. PubMed: Evaluation of genetic variability of wild hops (Humulus lupulus L.) in Canada and the Caucasus region by chemical and molecular methods. PubMed: Evaluation of brining ingredients and antimicrobials for effects on thermal destruction of Escherichia coli O157:H7 in a meat model system. PubMed: Effects of hops (Humulus lupulus L.) extract on volatile fatty acid production by rumen bacteria. PubMed: Transport of hop bitter acids across intestinal Caco-2 cell monolayers. PubMed: Identification of new phase II metabolites of xanthohumol in rat in vivo biotransformation of hop extracts using high-performance liquid chromatography electrospray ionization tandem mass spectrometry. PubMed: Crystal structure and substrate specificity of plant adenylate isopentenyltransferase from Humulus lupulus: distinctive binding affinity for purine and pyrimidine nucleotides. PubMed: Rho iso-alpha acids from hops inhibit the GSK-3/NF-kappaB pathway and reduce inflammatory markers associated with bone and cartilage degradation. PubMed: Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma. PubMed: Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. PubMed: Identification and RP-HPLC-ESI-MS/MS quantitation of bitter-tasting beta-acid transformation products in beer. PubMed: Capillary zone electrophoresis method for determination of bitter (alpha- and beta-) acids in hop (Humulus lupulus L.) cone extracts. PubMed: Control of Listeria monocytogenes on frankfurters by dipping in hops beta acids solutions. PubMed: Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive oxygen species. PubMed: LC-MS/MS quantitation of hop-derived bitter compounds in beer using the ECHO technique. PubMed: Antilisterial activity of hops beta acids in broth with or without other antimicrobials. PubMed: Terpene biosynthesis in glandular trichomes of hop. PubMed: Structural basis of human pregnane X receptor activation by the hops constituent colupulone. PubMed: Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS. PubMed: Protective effect of hop beta-acids on microbial degradation of thick juice during storage. PubMed: Studying the structural properties of polyalanine and polyglutamine peptides. PubMed: Constitutive expression of a grapevine stilbene synthase gene in transgenic hop (Humulus lupulus L.) yields resveratrol and its derivatives in substantial quantities. PubMed: NMR assignment of iso-alpha-acids from isomerised extracts of Humulus lupulus L. cones. PubMed: Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. PubMed: Relevance of organic farming and effect of climatological conditions on the formation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol in hop (Humulus lupulus L.). PubMed: Sensitive electrochemical detection method for alpha-acids, beta-acids and xanthohumol in hops (Humulus lupulus L.). PubMed: Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission. PubMed: Sedating effects of Humulus lupulus L. extracts. PubMed: Analysis of hop acids and their oxidized derivatives and iso-alpha-acids in beer by capillary electrophoresis-electrospray ionization mass spectrometry. PubMed: Characterization of the methanolic extract of hops using capillary electrophoresis-electrospray ionization-mass spectrometry. PubMed: Isohumulones modulate blood lipid status through the activation of PPAR alpha. PubMed: Generation of organic acids and monosaccharides by hydrolytic and oxidative transformation of food processing residues. PubMed: Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. PubMed: Mechanisms of cancer chemoprevention by hop bitter acids (beer aroma) through induction of apoptosis mediated by Fas and caspase cascades. PubMed: Antiviral activity of hop constituents against a series of DNA and RNA viruses. PubMed: Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2'-hydroxychalcones as a novel antioxidant pharmacophore. PubMed: Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.). PubMed: Comparative chemical attributes of native North American hop, Humulus lupulus var. lupuloides E. Small. PubMed: Mechanism for formation of the lightstruck flavor in beer revealed by time-resolved electron paramagnetic resonance. PubMed: Cloning and analysis of valerophenone synthase gene expressed specifically in lupulin gland of hop (Humulus lupulus L.). PubMed: Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. PubMed: The effect of colupulone (a HOPS beta-acid) on hepatic cytochrome P-450 enzymatic activity in the rat. PubMed: A modified TnphoA useful for single-stranded DNA sequencing. PubMed: Factors affecting antibacterial activity of hop compounds and their derivatives. PubMed: Slippery runs, shifty stops, backward steps, and forward hops: -2, -1, +1, +2, +5, and +6 ribosomal frameshifting.