carboxypeptidase
Identification
| Name | carboxypeptidase |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | GRN 345 |
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | enzyme preparations and microorganisms |
| Recommendation for carboxypeptidase usage levels up to | not for fragrance use. |
| Recommendation for carboxypeptidase flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
carboxypeptidase from modified aspergillus niger
PubMed:
Proteolytic Processing and Activation of Clostridium perfringens Epsilon Toxin by Caprine Small Intestinal Contents.
PubMed:
Role of PBPD1 in Stimulation of Listeria monocytogenes Biofilm Formation by Subminimal Inhibitory β-Lactam Concentrations.
PubMed:
Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.
PubMed:
Identification and Validation of Expressed Sequence Tags from Pigeonpea (Cajanus cajan L.) Root.
PubMed:
Metagenomic analyses reveal phylogenetic diversity of carboxypeptidase gene sequences in activated sludge of a wastewater treatment plant in Shanghai, China.
PubMed:
Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced obese male rats.
PubMed:
CuInS(2) quantum dots/poly((L)-glutamic acid)-drug conjugates for drug delivery and cell imaging.
PubMed:
Effect of polymorphisms in candidate genes on carcass and meat quality traits in double muscled Piemontese cattle.
PubMed:
Enzymatic production and degradation of cheese-derived non-proteolytic aminoacyl derivatives.
PubMed:
Identification of differential expression genes associated with host selection and adaptation between two sibling insect species by transcriptional profile analysis.
PubMed:
Genetic association analysis of 30 genes related to obesity in a European American population.
PubMed:
Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine αS-casein.
PubMed:
Simultaneous and combined detection of multiple tumor biomarkers for prostate cancer in human serum by suspension array technology.
PubMed:
Prolyl carboxypeptidase and its inhibitors in metabolism.
PubMed:
Glucarpidase to combat toxic levels of methotrexate in patients.
PubMed:
Chapter 24: Anaphylaxis.
PubMed:
Influence of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) on appetite and thrombosis.
PubMed:
Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.
PubMed:
Application of standard addition for the determination of carboxypeptidase activity in Actinomucor elegans bran koji.
PubMed:
Prolyl carboxypeptidase regulates energy expenditure and the thyroid axis.
PubMed:
Novel internally quenched fluorogenic substrates for angiotensin I-converting enzyme and carboxypeptidase Y.
PubMed:
Oral activity of FMRFamide-related peptides on the pea aphid Acyrthosiphon pisum (Hemiptera: Aphididae) and degradation by enzymes from the aphid gut.
PubMed:
Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population.
PubMed:
Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
PubMed:
Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer.
PubMed:
Effects of Manduca sexta allatostatin and an analogue on the peach-potato aphid Myzus persicae (hemiptera: aphididae) and degradation by enzymes in the aphid gut.
PubMed:
Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models.
PubMed:
Enzymatic activity of lactic acid bacteria (with antimicrobial properties) isolated from a traditional Spanish cheese.
PubMed:
Association of polymorphisms in candidate genes with colour, water-holding capacity, and composition traits in bovine M. longissimus and M. semimembranosus.
PubMed:
High enrichment of MMP-9 and carboxypeptidase A by tweezing adsorptive bubble separation (TABS).
PubMed:
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.
PubMed:
Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents.
PubMed:
Reduced levels of neurotransmitter-degrading enzyme PRCP promote a lean phenotype. [corrected].
PubMed:
Effects of Manduca sexta allatostatin and an analog on the pea aphid Acyrthosiphon pisum (Hemiptera: Aphididae) and degradation by enzymes from the aphid gut.
PubMed:
N-terminal modification increases the stability of the recombinant human endostatin in vitro.
PubMed:
The SpmA/B and DacF proteins of Clostridium perfringens play important roles in spore heat resistance.
PubMed:
Carboxypeptidase M: Multiple alliances and unknown partners.
PubMed:
Aroma precursors and methylpyrazines in underfermented cocoa beans induced by endogenous carboxypeptidase.
PubMed:
Identification of target genes for a MYB-type anthocyanin regulator in Gerbera hybrida.
PubMed:
Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits.
PubMed:
Debittering effect of Actinomucor elegans peptidases on soybean protein hydrolysates.
PubMed:
Risk assessment in anaphylaxis: current and future approaches.
PubMed:
High-level expression of milk-derived antihypertensive peptide in Escherichia coli and its bioactivity.
PubMed:
gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine.
PubMed:
The structure and function of Saccharomyces cerevisiae proteinase A.
PubMed:
Recombinant eggshell ovocalyxin-32: expression, purification and biological activity of the glutathione S-transferase fusion protein.
PubMed:
Ochratoxin degradation and adsorption caused by astaxanthin-producing yeasts.
PubMed:
EOS1, whose deletion confers sensitivity to oxidative stress, is involved in N-glycosylation in Saccharomyces cerevisiae.
PubMed:
Molecular properties and activities of tuber proteins from starch potato cv. Kuras.
PubMed:
Production of Brassica carinata protein hydrolyzates with a high Fischer's ratio using immobilized proteases.
PubMed:
Persistence of vanA-type Enterococcus faecium in Korean livestock after ban on avoparcin.
PubMed:
Cloning and characterization of cDNAS encoding carboxypeptidase-like proteins from the gut of Hessian fly larvae [Mayetiola destructor (Say)].
PubMed:
Alteration of pemetrexed excretion in the presence of acute renal failure and effusions: presentation of a case and review of the literature.
PubMed:
Biosensor analysis of beta-lactams in milk using the carboxypeptidase activity of a bacterial penicillin binding protein.
PubMed:
Angiotensin I-converting enzyme inhibitory peptide derived from glycinin, the 11S globulin of soybean (Glycine max).
PubMed:
Preliminary survey of ochratoxin A in millet, maize, rice and peanuts in Côte d'Ivoire from 1998 to 2002.
PubMed:
Characterization of the bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 of Listeria monocytogenes.
PubMed:
Heterologous expression of glycopeptide resistance vanHAX gene clusters from soil bacteria in Enterococcus faecalis.
PubMed:
Enzymatic activity of Campylobacter jejuni hippurate hydrolase.
PubMed:
Debittering effect of Monascus carboxypeptidase during the hydrolysis of soybean protein.
PubMed:
Enterocin AS-48RJ: a variant of enterocin AS-48 chromosomally encoded by Enterococcus faecium RJ16 isolated from food.
PubMed:
The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693.
PubMed:
Peptidomics of Cpe fat/fat mouse hypothalamus: effect of food deprivation and exercise on peptide levels.
PubMed:
Plasma folate as marker of folate status in epidemiological studies: the European Investigation into Cancer and Nutrition (EPIC)-Potsdam study.
PubMed:
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.
PubMed:
Bioavailability of polyglutamyl folic acid relative to that of monoglutamyl folic acid in subjects with different genotypes of the glutamate carboxypeptidase II gene.
PubMed:
Effect of voluntary exercise on genetically obese Cpefat/fat mice: quantitative proteomics of serum.
PubMed:
Biosensor analysis of beta-lactams in milk: comparison with microbiological, immunological, and receptor-based screening methods.
PubMed:
Quantification and kinetics of the decline in grass grub endopeptidase activity during initiation of amber disease.
PubMed:
Determination of beta-lactams in milk using a surface plasmon resonance-based biosensor.
PubMed:
Mass spectrometry and structural characterization of 2S albumin isoforms from Brazil nuts (Bertholletia excelsa).
PubMed:
Purification and characterization of a serine carboxypeptidase from Kluyveromyces marxianus.
PubMed:
Inhibitory profile of nonapeptide derived from porcine troponin C against angiotensin I-converting enzyme.
PubMed:
Evidence that cleavage of the precursor enzyme by autocatalysis caused secretion of multiple amylases by Aspergillus niger.
PubMed:
Reaction of lentil trypsin-chymotrypsin inhibitors with human and bovine proteinases.
PubMed:
Debittering of protein hydrolyzates.
PubMed:
Synthetic peptides as substrate for assaying the proteolytic activity of Lactobacillus helveticus.
PubMed:
Effect of acetic acid added to cooking water on the dissolution of proteins and activation of protease in rice.
PubMed:
Protease, peptidase and esterase activities by lactobacilli and yeast isolates from Feta cheese brine.
PubMed:
Real-time and conventional polymerase chain reaction systems based on the metallo-carboxypeptidase inhibitor gene for specific detection and quantification of potato and tomato in processed food.
PubMed:
Midgut proteases from Mamestra configurata (Lepidoptera: Noctuidae) larvae: characterization, cDNA cloning, and expressed sequence tag analysis.
PubMed:
Intestinal digestive resistance of immunodominant gliadin peptides.
PubMed:
The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohort.
PubMed:
Carboxypeptidases from A to z: implications in embryonic development and Wnt binding.
PubMed:
Analysis of the C-terminal structure of urinary Tamm-Horsfall protein reveals that the release of the glycosyl phosphatidylinositol-anchored counterpart from the kidney occurs by phenylalanine-specific proteolysis.
PubMed:
Purification and characterization of a carboxypeptidase from squid hepatopancreas (Illex illecebrosus).
PubMed:
Spontaneous nisin-resistant Listeria monocytogenes mutants with increased expression of a putative penicillin-binding protein and their sensitivity to various antibiotics.
PubMed:
Relative abundance and inhibitory distribution of protease inhibitors in potato juice from cv. Elkana.
PubMed:
Sulfur compounds reduce potato toxins during extrusion cooking.
PubMed:
Ochratoxin A in beverages from Morocco: a preliminary survey.
PubMed:
Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE).
PubMed:
Growth of Trichoderma viride on crude cell wall preparations from barley.
PubMed:
Degradation of gluten by proteases from dry and germinating wheat (Triticum durum) seeds: An in vitro approach to storage protein mobilization.
PubMed:
Determination of hydroxytryptophan isomers in gamma-irradiated egg white, chicken meat, and shrimps.
PubMed:
Regulation of intestinal peptidases by nutrients in human fetuses and children.
PubMed:
Proteolytic activities in dormant rye (Secale cereale L.) grain.
PubMed:
An experimental test of dietary enzyme modulation in pine warblers Dendroica pinus.
PubMed:
Peptides, enzymes and obesity: new insights from a 'dead' enzyme.
PubMed:
Disruption of the gene encoding penicillin-binding protein 2b (pbp2b) causes altered cell morphology and cease in exopolysaccharide production in Streptococcus thermophilus Sfi6.
PubMed:
Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice.
PubMed:
Proteinase inhibitors induce selective stimulation of human trypsin and chymotrypsin secretion.
PubMed:
Characterization of multiply phosphorylated peptides selectively precipitated from a pancreatic casein digest.
PubMed:
Detoxification of ochratoxin A, a food contaminant: Prevention of growth of Aspergillus ochraceus and its production of ochratoxin A.
PubMed:
Metabolism of enterostatin in rat intestine, brain membranes, and serum: differential involvement of proline-specific peptidases.
PubMed:
Growth stimulator for bifidobacteria produced by Propionibacterium freudenreichii and several intestinal bacteria.
PubMed:
The primary and subunit structure of a novel type killer toxin produced by a halotolerant yeast, Pichia farinosa.
PubMed:
Analytical methods for differentiating minor sequence variations in related peptides.
PubMed:
Gastric and pancreatic enzyme activities and their relationship with some gut regulatory peptides during postnatal development and weaning in calves.
PubMed:
Cloning and characterization of transcripts showing virulence-related gene expression in Naegleria fowleri.
PubMed:
Purification and partial characterization of an intracellular aminopeptidase from Streptococcus salivarius subsp. thermophilus strain ACA-DC 114.
PubMed:
Human ochratoxicosis in France.
PubMed:
Purification and Partial Characterization of a Prolyl-Dipeptidyl Aminopeptidase from Lactobacillus helveticus CNRZ 32.
PubMed:
Effect of Maillard reaction products on protein digestion.
PubMed:
The effect of varying dietary zinc levels on the concentration and localization of zinc in rat bile-pancreatic fluid.
PubMed:
Characterization of mesosomes of Micrococcus luteus: isolation and properties of mesosomal ribosomes, and localization of penicillin-binding proteins in mesosomal membranes.
PubMed:
Inactivation of metalloenzymes by food constituents.
PubMed:
Inactivation of metalloenzymes by lysinoalanine, phenylethylaminoalanine, alkali-treated food proteins, and sulfur amino acids.
PubMed:
Regulation of proteolytic enzyme activities and mRNA concentrations in rat pancreas by food content.
PubMed:
Agarose gel electrophoresis of duodenal juice in normal condition and in children with malabsorption.
PubMed:
Sequences of the soluble tryptic peptides from myoglobin of yellowfin tuna (Thunnus albacares).
PubMed:
Further characterization of tissue distribution and metabolism of (14C)aflatoxin B1 in chickens.
PubMed:
A carboxypeptidase from germinated barley and its action on casein.