15-acetyl deoxynivalenol
Identification
| Name | 15-acetyl deoxynivalenol |
| CAS Number | 88337-96-6 |
| FDA UNII | 0430X4R3Z1 |
| Molecular Formula | C17 H22 O7 |
| Molecular Weight | 338.35674000 |
| MDL Number | MFCD00083218 |
| Nikkaji Number | J275.533E |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 538.59 °C. @ 760.00 mm Hg (est) |
| Flash Point | 387.00 °F. TCC ( 197.40 °C. ) (est) |
| logP (o/w) | -0.400 (est) |
| Soluble in | water, 4044 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 113 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | toxic natural substances |
| Recommendation for 15-acetyl deoxynivalenol usage levels up to | not for fragrance use. |
| Recommendation for 15-acetyl deoxynivalenol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
15-
acetyldeoxynivalenol
trichothec-9-en-8-one, 15-(acetyloxy)-12,13-epoxy-3,7-dihydroxy-, (3-a,7-a)-
PubMed:
Biodegradation and biodetoxification of Fusarium mycotoxins by Sphaerodes mycoparasitica.
PubMed:
Identification and trichothecene genotypes of Fusarium graminearum species complex from wheat in Taiwan.
PubMed:
Multi-Mycotoxin Analysis in Durum Wheat Pasta by Liquid Chromatography Coupled to Quadrupole Orbitrap Mass Spectrometry.
PubMed:
Deoxynivalenol and Its Modified Forms: Are There Major Differences?
PubMed:
Multi-mycotoxin stable isotope dilution LC-MS/MS method for Fusarium toxins in beer.
PubMed:
Multi-mycotoxin contamination of couscous semolina commercialized in Morocco.
PubMed:
Endocrine activity of mycotoxins and mycotoxin mixtures.
PubMed:
Comparative in vitro cytotoxicity of modified deoxynivalenol on porcine intestinal epithelial cells.
PubMed:
Protein engineering of Saccharomyces cerevisiae transporter Pdr5p identifies key residues that impact Fusarium mycotoxin export and resistance to inhibition.
PubMed:
Binary and tertiary combination of alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on HepG2 cells: Toxic effects and evaluation of degradation products.
PubMed:
Effect of 4-week feeding of deoxynivalenol- or T-2-toxin-contaminated diet on lipid peroxidation and glutathione redox system in the hepatopancreas of common carp (Cyprinus carpio L.).
PubMed:
Transformation of deoxynivalenol and its acetylated derivatives in Chinese steamed bread making, as affected by pH, yeast, and steaming time.
PubMed:
Identification and Characterization of Carboxylesterases from Brachypodium distachyon Deacetylating Trichothecene Mycotoxins.
PubMed:
[Dietary exposure assessment of deoxynivalenol and its acetylate & derivatives in wheat flour in Shanghai].
PubMed:
The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-O-Glucoside, 15-Acetyl-DON-3-O-Glucoside and 15-Acetyl-DON-3-Sulfate.
PubMed:
A method for simultaneous determination of 20 Fusarium toxins in cereals by high-resolution liquid chromatography-Orbitrap mass spectrometry with a pentafluorophenyl column.
PubMed:
Evaluation on levels and conversion profiles of DON, 3-ADON, and 15-ADON during bread making process.
PubMed:
Comparative assessment of three cleanup procedures after QuEChERS extraction for determination of trichothecenes (type A and type B) in processed cereal-based baby foods by GC-MS.
PubMed:
Cytotoxic effects and degradation products of three mycotoxins: alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in liver hepatocellular carcinoma cells.
PubMed:
Development and validation of an LC-MS/MS method for the toxicokinetic study of deoxynivalenol and its acetylated derivatives in chicken and pig plasma.
PubMed:
Mycotoxigenic potential of fungi isolated from freshly harvested Argentinean blueberries.
PubMed:
Fusarium species, chemotype characterisation and trichothecene contamination of durum and soft wheat in an area of central Italy.
PubMed:
Transcriptome profiling of wheat differentially expressed genes exposed to different chemotypes of Fusarium graminearum.
PubMed:
Evidence for a reversible drought induced shift in the species composition of mycotoxin producing Fusarium head blight pathogens isolated from symptomatic wheat heads.
PubMed:
Fitness attributes of Fusarium graminearum isolates from wheat in New York possessing a 3-ADON or 15-ADON trichothecene genotype.
PubMed:
Occurrence of Fusarium mycotoxins in Italian cereal and cereal products from organic farming.
PubMed:
Survey of 7 trichothecenes in corn-derived feed and feed ingredients.
PubMed:
Inter-laboratory study of an LC-MS/MS method for simultaneous determination of deoxynivalenol and its acetylated derivatives, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in wheat.
PubMed:
Simultaneous determination of masked deoxynivalenol and some important type B trichothecenes in Chinese corn kernels and corn-based products by ultra-performance liquid chromatography-tandem mass spectrometry.
PubMed:
Development of a purification method for simultaneous determination of deoxynivalenol and its acetylated and glycosylated derivatives in corn grits and corn flour by liquid chromatography-tandem mass spectrometry.
PubMed:
TRI12 based quantitative real-time PCR assays reveal the distribution of trichothecene genotypes of F. graminearum and F. culmorum isolates in Danish small grain cereals.
PubMed:
Heat- and cold-shock responses in Fusarium graminearum 3 acetyl- and 15 acetyl-deoxynivalenol chemotypes.
PubMed:
Population analysis of the Fusarium graminearum species complex from wheat in China show a shift to more aggressive isolates.
PubMed:
Chemotaxonomic diagnostics: combining sucrose-water agar with TLC to discriminate Fusarium graminearum 3-acetyl-DON and 15-acetyl-DON chemotypes.
PubMed:
Cross-reactivity of some commercially available deoxynivalenol (DON) and zearalenone (ZEN) immunoaffinity columns to DON- and ZEN-conjugated forms and metabolites.
PubMed:
Construction and characterization of a cDNA library from wheat infected with Fusarium graminearum Fg 2.
PubMed:
The 3ADON population of Fusarium graminearum found in North Dakota is more aggressive and produces a higher level of DON than the prevalent 15ADON population in spring wheat.
PubMed:
Effects of dietary Fusarium mycotoxins on intestinal lymphocyte subset populations, cell proliferation and histological changes in avian lymphoid organs.
PubMed:
Trichothecene chemotypes of Fusarium culmorum infecting wheat in Tunisia.
PubMed:
Quantification of Fusarium graminearum in harvested grain by real-time polymerase chain reaction to assess efficacies of fungicides on fusarium head blight, deoxynivalenol contamination, and yield of winter wheat.
PubMed:
Comparative mycotoxin profiles of Gibberella zeae populations from barley, wheat, potatoes, and sugar beets.
PubMed:
Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol.
PubMed:
LC-MS/MS multi-method for mycotoxins after single extraction, with validation data for peanut, pistachio, wheat, maize, cornflakes, raisins and figs.
PubMed:
Effects of foodborne Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on food intake and nutrient digestibility, body weight, and physical and clinicopathologic variables of mature dogs.
PubMed:
Estimating mycotoxin contents of Fusarium-damaged winter wheat kernels.
PubMed:
Effects of feeding grains naturally contaminated with Fusarium mycotoxins on performance and metabolism of broiler breeders.
PubMed:
Multiplex PCR assay for the identification of nivalenol, 3- and 15-acetyl-deoxynivalenol chemotypes in Fusarium.
PubMed:
Simultaneous determination of type A-& B-trichothecenes and zearalenone in cereals by High Performance Liquid Chromatography - Tandem Mass Spectrometry.
PubMed:
[Determination of DON-3-Glucoside in artificially and naturally contaminated wheat with LC-MS/MS].
PubMed:
Solvolysis procedures for the determination of bound residues of the mycotoxin deoxynivalenol in fusarium species infected grain of two winter wheat cultivars preinfected with barley yellow dwarf virus.
PubMed:
Incidence of trichothecenes and zearalenone in poultry feed mixtures from Slovakia.
PubMed:
Assessment of trichothecene chemotypes of Fusarium culmorum occurring in Europe.
PubMed:
DON calibrant: Towards the production of certified B-trichothecene calibrants.
PubMed:
Rapid simultaneous determination of major type A- and B-trichothecenes as well as zearalenone in maize by high performance liquid chromatography-tandem mass spectrometry.
PubMed:
Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes.
PubMed:
Report from SCOOP task 3.2.10 "collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states". Subtask: trichothecenes.
PubMed:
Zearalenone in maize: stability testing and matrix characterisation of a certified reference material.
PubMed:
Rapid surface plasmon resonance-based inhibition assay of deoxynivalenol.
PubMed:
Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana.
PubMed:
Fast methods for screening of trichothecenes in fungal cultures using gas chromatography-tandem mass spectrometry.
PubMed:
Occurrence of trichothecenes in Argentinean beer: a preliminary exposure assessment.
PubMed:
A survey of Fusarium toxins in cereal-based foods marketed in an area of southwest Germany.
PubMed:
Natural occurrence of Fusarium toxins in oats harvested during five years in an area of southwest Germany.
PubMed:
Production of trichothecenes and zearalenone by isolates of Fusarium spp. from Argentinian maize.
PubMed:
Mycotoxins in fungal contaminated samples of animal feed from western Canada, 1982-1994.
PubMed:
Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells.
PubMed:
Cumulation of mycotoxins in maize cobs infected withFusarium gramihearum.
PubMed:
Natural occurrence of deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, nivalenol, 4,7-dideoxynivalenol, and zearalenone in polish wheat.
PubMed:
Mycotoxins and Fusarium spp. associated with infected ears of corn in Minnesota.
PubMed:
Natural occurrence and clastogenic effects of nivalenol, deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in corn from a high-risk area of esophageal cancer.
PubMed:
[Trichothecenes in staple food from a high-incidence area of carcinoma of the esophagus and gastric cardia and their carcinogenic potential].
PubMed:
Natural occurrence of deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in refusal factor corn stored since 1972.
PubMed:
Deoxynivalenol and 15-monoacetyl deoxynivalenol production by Fusarium graminearum R6576 in liquid media.