deoxyschizandrin
schisandrin A
Identification
| Name | deoxyschizandrin |
| CAS Number | 61281-38-7 |
| FDA UNII | 74XQL5DO3S |
| Molecular Formula | C24 H32 O6 |
| Molecular Weight | 416.51424000 |
| MDL Number | MFCD09026934 |
| Nikkaji Number | J527.345E |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 544.20 °C. @ 760.00 mm Hg (est) |
| Flash Point | 420.00 °F. TCC ( 215.60 °C. ) (est) |
| logP (o/w) | 5.870 (est) |
| Soluble in | water, 0.00323 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LDLo 1000 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for deoxyschizandrin usage levels up to | not for fragrance use. |
| Recommendation for deoxyschizandrin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, stereoisomer
dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-6,7-dimethyl-1,2,3,10,11,12-hexamethoxy-
dibenzo[a,c]cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-
1,2,3,10,11,12-
hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulene
schisandrin A
schizandrin A
PubMed:
[Correlation study on lignin contents of Schisandra chinensis and ecological factors].
PubMed:
Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro.
PubMed:
[High performance preparation and structural confirmation of lignans from Schisandrae chinensis fructus by using HSCCC combined with ESI-MSn method].
PubMed:
Optimization of vinegar-steaming process for Wuweizi (Fructus Schisandrae Chinensis) with response surface method.
PubMed:
Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS/MS based on multiple mass defect filter data acquisition and multiple data processing techniques.
PubMed:
[Determination of lignans in four fruits of Schisandra genus in Qinling mountains].
PubMed:
Deoxyschizandrin, a naturally occurring lignan, is a specific probe substrate of human cytochrome P450 3A.
PubMed:
Determination of lignans in Wuweizi by using magnetic bar microextraction and HPLC.
PubMed:
Chemical-pharmacokinetic-pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract.
PubMed:
Effects of piperine and deoxyschizandrin on synchronized Ca²⺠oscillations in cultured hippocampal neuronal cells.
PubMed:
[Quality evaluation and antioxidant activity research of Schisandra chinensis from various habitats].
PubMed:
Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay.
PubMed:
Effects of traditional chinese medicine Wuzhi capsule on pharmacokinetics of tacrolimus in rats.
PubMed:
Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats.
PubMed:
Production of deoxyschizandrin and γ-schizandrin in shoot-differentiating and undifferentiating callus cultures of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine).
PubMed:
Effect of acupuncture on target tissue distribution of Schisandra lignans.
PubMed:
Schisandra lignans-loaded enteric nanoparticles: preparation, characterization, and in vitro-in vivo evaluation.
PubMed:
Strong inhibition of deoxyschizandrin and schisantherin A toward UDP-glucuronosyltransferase (UGT) 1A3 indicating UGT inhibition-based herbâdrug interaction.
PubMed:
Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS.
PubMed:
[Chemical constituents of petroleum ether extract of fruits of Schisandra sphenanthera].
PubMed:
[Simultaneous quantitative analysis of four lignanoids in Schisandra chinensis by quantitative analysis of multi-components by single marker].
PubMed:
Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition.
PubMed:
Application of ultrahigh-performance liquid chromatography coupled with mass spectrometry for analysis of lignans and quality control of Fructus Schisandrae chinensis.
PubMed:
[Correlation of lignans content and antioxidant activities of Schisandra chinensis fruits by using stoichiometry method].
PubMed:
Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Aβââââ-induced memory impairment in mice.
PubMed:
Aqueous two-phase system coupled with ultrasound for the extraction of lignans from seeds of Schisandra chinensis (turcz.) Baill.
PubMed:
Response surface modeling and optimization of accelerated solvent extraction of four lignans from fructus schisandrae.
PubMed:
Effects of H(2)O(2), paraquat, and ethephon on herbal drug quality of Schiandra chinensis based on reactive oxygen species system.
PubMed:
Enrichment and purification of deoxyschizandrin and γ-schizandrin from the extract of Schisandra chinensis fruit by macroporous resins.
PubMed:
On-line continuous sampling dynamic microwave-assisted extraction coupled with high performance liquid chromatographic separation for the determination of lignans in Wuweizi and naphthoquinones in Zicao.
PubMed:
A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives.
PubMed:
Homogeneous ionic liquid microextraction of the active constituents from fruits of Schisandra chinensis and Schisandra sphenanthera.
PubMed:
Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells.
PubMed:
[Study on the clinical application of wuzhi capsule after renal transplantation].
PubMed:
Preparation of high purity biphenyl cyclooctene lignans from Schisandra extract by ion exchange resin catalytic transformation combined with macroporous resin separation.
PubMed:
Screening vasoconstriction inhibitors from traditional Chinese medicines using a vascular smooth muscle/cell membrane chromatography-offline-liquid chromatography-mass spectrometry.
PubMed:
[Identification of the lignans components after oral administration of fuzheng huayu decoction in rat serum by HPLC-MSn].
PubMed:
Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.
PubMed:
The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-γ pathways in in vitro and in vivo studies.
PubMed:
[Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A].
PubMed:
Study on ionic liquid-based ultrasonic-assisted extraction of biphenyl cyclooctene lignans from the fruit of Schisandra chinensis Baill.
PubMed:
[Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ].
PubMed:
Rapid determination and pharmacokinetics study of lignans in rat plasma after oral administration of Schisandra chinensis extract and pure deoxyschisandrin.
PubMed:
Deoxyschisandrin inhibits H2O2-induced apoptotic cell death in intestinal epithelial cells through nuclear factor-kappaB.
PubMed:
Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A.
PubMed:
Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity.
PubMed:
[Changes of lignans' content in stems of Schisandra chinensis].
PubMed:
[Research on liposoluble ingredients of Quchiling].
PubMed:
Validated method for bioactive lignans in Schisandra chinensis in vitro cultures using a solid phase extraction and a monolithic column application.
PubMed:
Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract.
PubMed:
[Selection of mobile phases for the determination of gamma-schisandrin and multi-active constituents in Schisandra chinensis and its preparations by high performance liquid chromatography].
PubMed:
The effect of deoxyschisandrin on blood tacrolimus levels: a case report.
PubMed:
Schisanwilsonins A-G and related anti-HBV lignans from the fruits of Schisandra wilsoniana.
PubMed:
Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells.
PubMed:
Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells--study of structure-activity relationship.
PubMed:
Resolution of two-way chromatographic data of Schisandra chinensis Baill. using a modified slice-scan method for direct determination of the components in overlapping peaks.
PubMed:
[Lignans from different processed products of Schisandra chinensis fruits].
PubMed:
Optimization of extraction and purification of active fractions from Schisandra chinensis (Turcz.) and its osteoblastic proliferation stimulating activity.
PubMed:
Deoxyschisandrin modulates synchronized Ca2+ oscillations and spontaneous synaptic transmission of cultured hippocampal neurons.
PubMed:
Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae.
PubMed:
Determination of deoxyschizandrin in rat plasma by LC-MS.
PubMed:
Molecular mechanism of apoptosis induced by schizandrae-derived lignans in human leukemia HL-60 cells.
PubMed:
[Determination of tanshinone II A and deoxyschizandrin in danshenwuweizi tablet by RP-HPLC].
PubMed:
Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis.
PubMed:
Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2.
PubMed:
Development of a quality evaluation method for Fructus schisandrae by pressurized capillary electrochromatography.
PubMed:
Microwave-assisted extraction and fingerprint studies of Schisandra chinensis (Turcz.) by high performance liquid chromatography and gas chromatography.
PubMed:
Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein.
PubMed:
Separation and determination of active components in Schisandra chinensis Baill. and its medicinal preparations by non-aqueous capillary electrophoresis.
PubMed:
Preparative separation and purification of deoxyschisandrin and gamma-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography.
PubMed:
[Study on the simultaneous spectrophotometric determination of three components including deoxyschizandrin by ridge regression method].
PubMed:
[Determination of lignans of Schisandra medicinal plants by HPLC].
PubMed:
Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination.
PubMed:
[Studies on extraction process of Fructus Schisandrae chinensis and Fructus Ligustri lucidi in gandening tablet].
PubMed:
Determination of specific receptor sites for platelet activating factor in bovine neutrophils.
PubMed:
Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.
PubMed:
[Determination of schisandrin in shengmaiyin by HPLC].
PubMed:
[Study on supercritical CO2 fluid extraction and separation of components from fruits of Schisandra sphenanthera].
PubMed:
Liquid chromatographic analysis of supercritical carbon dioxide extracts of Schizandra chinensis.
PubMed:
Release of intermediate reactive hydrogen peroxide by macrophage cells activated by natural products.
PubMed:
Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats.
PubMed:
Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice.
PubMed:
Detection of free radical scavenging activity of schisanhenol by electron spin resonance.
PubMed:
[Mass spectrometric studies on dibenzocyclooctadiene lignan compounds from Schisandraceae plants].
PubMed:
Pharmacological actions and clinical use of fructus schizandrae.
PubMed:
Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity.