gomisin A

benzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7R)- besigomsin schisandrol B schizandrol B (+)-(6S,7S, biar-R)-5,6,7,8- tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol (6R,7R)-1,2,3,13- tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol wuweizi alcohol B wuweizichun B PubMed: Gomisin A decreases the LPS-induced expression of iNOS and COX-2 and activation of RIP2/NF-κB in mouse peritoneal macrophages. PubMed: Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway. PubMed: An efficient strategy for the extraction and purification of lignans from Schisandra chinensis by a combination of supercritical fluid extraction and high-speed counter-current chromatography. PubMed: Micelle-Mediated Extraction of Dibenzocyclooctadiene Lignans from Schisandra chinensis with Analysis by High-Performance Liquid Chromatography. PubMed: Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury. PubMed: Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein. PubMed: Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: 'antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability' by Park et al. PubMed: Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability. PubMed: The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury. PubMed: Production of lignans in calluses of Schisandra chinensis. PubMed: A compound isolated from Schisandra chinensis induces apoptosis. PubMed: Transcriptome analysis of the effects of gomisin a on the recovery of carbon tetrachloride-induced damage in rat liver. PubMed: The immuno-regulatory effects of Schisandra chinensis and its constituents on human monocytic leukemia cells. PubMed: The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-γ pathways in in vitro and in vivo studies. PubMed: Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. PubMed: Effects of gomisin A on vascular contraction in rat aortic rings. PubMed: Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS. PubMed: Identification of marker compounds in herbal drugs on TLC with DART-MS. PubMed: Evaluation of cytotoxic activity of Schisandra chinensis lignans. PubMed: Dibenzocyclooctadiene lignans from Fructus Schisandrae Chinensis improve glucose uptake in vitro. PubMed: Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis. PubMed: Validated method for bioactive lignans in Schisandra chinensis in vitro cultures using a solid phase extraction and a monolithic column application. PubMed: Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill. PubMed: [Study on the chemical constituents of the fruit handles from Schizandra chinensis]. PubMed: Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract. PubMed: Gomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cells. PubMed: Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells--study of structure-activity relationship. PubMed: Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells. PubMed: Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport. PubMed: Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. PubMed: Gomisin A from Schisandra chinensis induces endothelium-dependent and direct relaxation in rat thoracic aorta. PubMed: High-performance liquid chromatography-electrospray mass spectrometry for the simultaneous determination of multiple active components in Sheng-Mai San, a prescription of traditional Chinese medicine. PubMed: Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis. PubMed: Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis. PubMed: Development of a quality evaluation method for Fructus schisandrae by pressurized capillary electrochromatography. PubMed: Natural products and chronic hepatitis C virus. PubMed: Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells. PubMed: Gomisin A improves scopolamine-induced memory impairment in mice. PubMed: Application of preparative high-speed counter-current chromatography for isolation and separation of schizandrin and gomisin A from Schisandra chinensis. PubMed: [Determination of lignans of Schisandra medicinal plants by HPLC]. PubMed: Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination. PubMed: Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. PubMed: Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. PubMed: Liquid chromatographic analysis of supercritical carbon dioxide extracts of Schizandra chinensis. PubMed: [Phytotherapeutic aspects of diseases of the circulatory system. 7. Schisandra chinensis (Turcz.) Baill.): its composition and biological activity]. PubMed: Application of capillary electrochromatography using macroporous polyacrylamide columns for the analysis of lignans from seeds of Schisandra chinensis. PubMed: Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine. PubMed: Lignans in the seeds and fruits of Schisandra chinensis cultured in Europe. PubMed: Rapid induction of hepatocyte growth factor mRNA after administration of gomisin A, a lignan component of shizandra fruits. PubMed: Deoxycholic acid as an endogenous risk factor for hepatocarcinogenesis and effects of gomisin A, a lignan component of Schizandra fruits. PubMed: Effects of gomisin A on the promotor action and serum bile acid concentration in hepatocarcinogenesis induced by 3'-methyl-4-dimethylamino-azobenzene. PubMed: Inhibition of early 3-methyl-4-dimethylaminoazobenzene-induced hepatocarcinogenesis by gomisin A in rats. PubMed: Inhibition by gomisin A, a lignan compound, of hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene in rats. PubMed: Gomisin A, a lignan component of Schizandora fruits, inhibits development of preneoplastic lesions in rat liver by 3'-methyl-4-dimethylamino-azobenzene. PubMed: Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats. PubMed: Effect of Gomisin A (TJN-101) on liver regeneration. PubMed: Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. PubMed: [Determination of gomisin A (TJN-101) and its metabolite in rat serum by gas chromatography-mass spectrometry]. PubMed: Effects of gomisin A on hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene in rats. PubMed: [Studies on the metabolic fate of gomisin A (TJN-101). II. Absorption and excretion in CCl4 treated rats]. PubMed: [Studies on the metabolic fate of gomisin A (TJN-101). I. Absorption in rats]. PubMed: Effect of gomisin A in the prevention of acute hepatic failure induction. PubMed: Effect of gomisin A in an immunologically-induced acute hepatic failure model. PubMed: Effect of gomisin A (TJN-101) on the arachidonic acid cascade in macrophages. PubMed: Studies on the metabolism of gomisin A (TJN-101). II. Structure determination of biliary and urinary metabolites in rat. PubMed: The effect of gomisin A on immunologic liver injury in mice. PubMed: Studies on the metabolism of gomisin A (TJN-101). I. Oxidative products of gomisin A formed by rat liver S9 mix. PubMed: [Effect of gomisin A (TJN-101), a lignan compound isolated from Schisandra fruits, on liver function in rats]. PubMed: [The protective effect of gomisin A on experimentally induced acute hepatic injury]. PubMed: [Effects of gomisin A, a lignan component of Schizandra fruits, on experimental liver injuries and liver microsomal drug-metabolizing enzymes]. PubMed: Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A1. PubMed: Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A. PubMed: Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats. PubMed: [Pharmacological studies on Schizandra fruit. I. General pharmacological effects of gomisin A and schizandrin (author's transl)]. PubMed: The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin.