gomisin N
deoxygomisin A
Identification
| Name | gomisin N |
| CAS Number | 69176-52-9 |
| FDA UNII | DKO6O75Z5V |
| Molecular Formula | C23 H28 O6 |
| Molecular Weight | 400.47136000 |
| Nikkaji Number | J1.033.305I |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 545.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 429.00 °F. TCC ( 220.40 °C. ) (est) |
| logP (o/w) | 6.460 (est) |
| Soluble in | water, 0.001173 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for gomisin N usage levels up to | not for fragrance use. |
| Recommendation for gomisin N flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13aR)-
benzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S)-
deoxygomisin A
schizandrin B
(6R,7S)-1,2,3,13-
tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole
wuweizisu B
PubMed:
Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.
PubMed:
Micelle-Mediated Extraction of Dibenzocyclooctadiene Lignans from Schisandra chinensis with Analysis by High-Performance Liquid Chromatography.
PubMed:
Differential effect of schisandrin B stereoisomers on ATR-mediated DNA damage checkpoint signaling.
PubMed:
UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in normal and insomniac rats brain microdialysates and homogenate samples: towards an in-depth study for its sedative-hypnotic activity.
PubMed:
Development of a UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats.
PubMed:
Purification of lignans from Schisandra chinensis fruit by using column fractionation and supercritical antisolvent precipitation.
PubMed:
The effects of lignan-riched extract of Shisandra chinensis on amyloid-β-induced cognitive impairment and neurotoxicity in the cortex and hippocampus of mouse.
PubMed:
Gomisin N in the herbal drug gomishi (Schisandra chinensis) suppresses inducible nitric oxide synthase gene via C/EBPβ and NF-κB in rat hepatocytes.
PubMed:
Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/β-catenin signaling pathway in HCT116 cells.
PubMed:
[Determination of six lignin components in crude and different processed products of Schisandra chinensis].
PubMed:
Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5.
PubMed:
Effects of Schisandra chinensis extract on the contractility of corpus cavernosal smooth muscle (CSM) and Ca2+ homeostasis in CSM cells.
PubMed:
The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-γ pathways in in vitro and in vivo studies.
PubMed:
Gomisin N has anti-allergic effect and inhibits inflammatory cytokine expression in mouse bone marrow-derived mast cells.
PubMed:
Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways.
PubMed:
Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS.
PubMed:
Isolation of lignans from Schisandra chinensis with anti-proliferative activity in human colorectal carcinoma: Structure-activity relationships.
PubMed:
Evaluation of cytotoxic activity of Schisandra chinensis lignans.
PubMed:
Dibenzocyclooctadiene lignans from Fructus Schisandrae Chinensis improve glucose uptake in vitro.
PubMed:
Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis.
PubMed:
Validated method for bioactive lignans in Schisandra chinensis in vitro cultures using a solid phase extraction and a monolithic column application.
PubMed:
Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill.
PubMed:
Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma.
PubMed:
Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells--study of structure-activity relationship.
PubMed:
Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells.
PubMed:
Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport.
PubMed:
Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination.
PubMed:
Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.
PubMed:
Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis.
PubMed:
Liquid chromatographic analysis of supercritical carbon dioxide extracts of Schizandra chinensis.
PubMed:
[Phytotherapeutic aspects of diseases of the circulatory system. 7. Schisandra chinensis (Turcz.) Baill.): its composition and biological activity].
PubMed:
Application of capillary electrochromatography using macroporous polyacrylamide columns for the analysis of lignans from seeds of Schisandra chinensis.
PubMed:
Lignans in the seeds and fruits of Schisandra chinensis cultured in Europe.