gomisin N

deoxygomisin A

CAS: 69176-52-9 C23 H28 O6 MW: 400.47136000

Identification

Namegomisin N
CAS Number69176-52-9
FDA UNIIDKO6O75Z5V
Molecular FormulaC23 H28 O6
Molecular Weight400.47136000
Nikkaji NumberJ1.033.305I

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 545.00 °C. @ 760.00 mm Hg (est)
Flash Point 429.00 °F. TCC ( 220.40 °C. ) (est)
logP (o/w) 6.460 (est)
Soluble in water, 0.001173 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for gomisin N usage levels up tonot for fragrance use.
Recommendation for gomisin N flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

schisandra incarnata

Synonyms

benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13aR)- benzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S)- deoxygomisin A schizandrin B (6R,7S)-1,2,3,13- tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole wuweizisu B PubMed: Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system. PubMed: Micelle-Mediated Extraction of Dibenzocyclooctadiene Lignans from Schisandra chinensis with Analysis by High-Performance Liquid Chromatography. PubMed: Differential effect of schisandrin B stereoisomers on ATR-mediated DNA damage checkpoint signaling. PubMed: UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in normal and insomniac rats brain microdialysates and homogenate samples: towards an in-depth study for its sedative-hypnotic activity. PubMed: Development of a UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats. PubMed: Purification of lignans from Schisandra chinensis fruit by using column fractionation and supercritical antisolvent precipitation. PubMed: The effects of lignan-riched extract of Shisandra chinensis on amyloid-β-induced cognitive impairment and neurotoxicity in the cortex and hippocampus of mouse. PubMed: Gomisin N in the herbal drug gomishi (Schisandra chinensis) suppresses inducible nitric oxide synthase gene via C/EBPβ and NF-κB in rat hepatocytes. PubMed: Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/β-catenin signaling pathway in HCT116 cells. PubMed: [Determination of six lignin components in crude and different processed products of Schisandra chinensis]. PubMed: Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5. PubMed: Effects of Schisandra chinensis extract on the contractility of corpus cavernosal smooth muscle (CSM) and Ca2+ homeostasis in CSM cells. PubMed: The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-γ pathways in in vitro and in vivo studies. PubMed: Gomisin N has anti-allergic effect and inhibits inflammatory cytokine expression in mouse bone marrow-derived mast cells. PubMed: Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. PubMed: Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS. PubMed: Isolation of lignans from Schisandra chinensis with anti-proliferative activity in human colorectal carcinoma: Structure-activity relationships. PubMed: Evaluation of cytotoxic activity of Schisandra chinensis lignans. PubMed: Dibenzocyclooctadiene lignans from Fructus Schisandrae Chinensis improve glucose uptake in vitro. PubMed: Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. PubMed: Validated method for bioactive lignans in Schisandra chinensis in vitro cultures using a solid phase extraction and a monolithic column application. PubMed: Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill. PubMed: Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma. PubMed: Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells--study of structure-activity relationship. PubMed: Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells. PubMed: Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport. PubMed: Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination. PubMed: Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. PubMed: Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis. PubMed: Liquid chromatographic analysis of supercritical carbon dioxide extracts of Schizandra chinensis. PubMed: [Phytotherapeutic aspects of diseases of the circulatory system. 7. Schisandra chinensis (Turcz.) Baill.): its composition and biological activity]. PubMed: Application of capillary electrochromatography using macroporous polyacrylamide columns for the analysis of lignans from seeds of Schisandra chinensis. PubMed: Lignans in the seeds and fruits of Schisandra chinensis cultured in Europe.