aminosuberic acid
L-a-aminosuberic acid
Identification
| Name | aminosuberic acid |
| CAS Number | 4254-88-0 |
| EINECS | 224-231-3 |
| FDA UNII | B347Q73CGH |
| Molecular Formula | C8 H15 N O4 |
| Molecular Weight | 189.21135000 |
| Nikkaji Number | J205.668B |
| XlogP3 | -2.20 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 385.52 °C. @ 760.00 mm Hg (est) |
| Flash Point | 369.00 °F. TCC ( 187.00 °C. ) (est) |
| logP (o/w) | -0.075 (est) |
| Soluble in | water, 4.359e+004mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | emollients |
| Recommendation for aminosuberic acid usage levels up to | not for fragrance use. |
| Recommendation for aminosuberic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(2S)-2-
aminooctanedioic acid
(S)-2-
aminooctanedioic acid
L-a-
aminosuberic acid
octanedioic acid, 2-amino-, (2S)-
PubMed:
A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the x(C)â» transporter.
PubMed:
Functional imaging of oxidative stress with a novel PET imaging agent, 18F-5-fluoro-L-aminosuberic acid.
PubMed:
Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid.
PubMed:
The peptides of alpha-aminosuberic acid I. New intermediates for synthetic studies.
PubMed:
Resolution of DL-2-aminosuberic acid via protease-catalyzed ester hydrolysis.
PubMed:
The peptides of alpha-aminosuberic acid II. Synthesis of deamino-dicarba-eel-calcitonin sequence 1-9.
PubMed:
1,6-Aminosuberic acid analogs of lysine- and arginine-vasopressin and -vasotocin. Synthesis and biological properties.
PubMed:
[Tritium-labeled reactive analogs of [1,6-alpha-aminosuberic acid, 8-arginine] vasopressin (deamino-dicarba-[8-arginine] vasopressin. synthesis and properties].
PubMed:
[1,6-alpha-aminosuberic acid,3-(p-azidophenylalanine), 8-arginine] vasopressin as a photoaffinity label for renal vasopressin receptors: an evaluation.
PubMed:
[1,6-alpha-aminosuberic acid, 3-(p-azidophenylalanine), 8-arginine] vasopressin: a new photoaffinity label for hydroosmotic hormone receptors. Characterization of the ligand and irreversible stimulation of hydroosmotic water flow in toad bladder by photoaffinity labeling.
PubMed:
Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors.
PubMed:
Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax.
PubMed:
Amino acids with aryl-keto function in their side chains.
PubMed:
Tandem enzymatic resolution yielding L-alpha-aminoalkanedioic acid omega-esters.
PubMed:
Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord.
PubMed:
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.
PubMed:
Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity.
PubMed:
Potent antimalarial activity of histone deacetylase inhibitor analogues.
PubMed:
Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity.
PubMed:
Conformational studies of oxytocin analogues with different ring sizes. I. Circular dichroism.
PubMed:
Enzymatic semisynthesis of dicarba analogs of calcitonin.
PubMed:
Neurohypophyseal hormones, analogs, and fragments: their effect on puromycin-induced amnesia.
PubMed:
Aliphatic amino diacid Asu functions as an effective mimic of Tyr(SO3H) in sulfakinins for myotropic and food intake-inhibition activity in insects.
PubMed:
[Asu(1,7)E-CT, an analog of eel calcitonin. A comparative study in man with reference to other synthetic calcitonins].
PubMed:
Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies.
PubMed:
Investigation of cyclic depsipeptides by fast atom bombardment-mass spectrometry.
PubMed:
Analogues of the cytostatic and antimitogenic agents chlamydocin and HC-toxin: synthesis and biological activity of chloromethyl ketone and diazomethyl ketone functionalized cyclic tetrapeptides.
PubMed:
[Effect of Asu-AVT on electroacupuncture (EA) analgesia].
PubMed:
A dicarba analog of beta-atrial natriuretic peptide (beta-ANP) inhibits guanosine 3',5'-cyclic monophosphate production induced by alpha-ANP in cultured rat vascular smooth muscle cells.
PubMed:
Calcitonin binding and degradation by two cultured human breast cancer cell lines (MCF 7 and T 47D).