aminosuberic acid

L-a-aminosuberic acid

CAS: 4254-88-0 C8 H15 N O4 MW: 189.21135000

Identification

Nameaminosuberic acid
CAS Number4254-88-0
EINECS224-231-3
FDA UNIIB347Q73CGH
Molecular FormulaC8 H15 N O4
Molecular Weight189.21135000
Nikkaji NumberJ205.668B
XlogP3-2.20 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 385.52 °C. @ 760.00 mm Hg (est)
Flash Point 369.00 °F. TCC ( 187.00 °C. ) (est)
logP (o/w) -0.075 (est)
Soluble in water, 4.359e+004mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryemollients
Recommendation for aminosuberic acid usage levels up tonot for fragrance use.
Recommendation for aminosuberic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

(2S)-2- aminooctanedioic acid (S)-2- aminooctanedioic acid L-a- aminosuberic acid octanedioic acid, 2-amino-, (2S)- PubMed: A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the x(C)⁻ transporter. PubMed: Functional imaging of oxidative stress with a novel PET imaging agent, 18F-5-fluoro-L-aminosuberic acid. PubMed: Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid. PubMed: The peptides of alpha-aminosuberic acid I. New intermediates for synthetic studies. PubMed: Resolution of DL-2-aminosuberic acid via protease-catalyzed ester hydrolysis. PubMed: The peptides of alpha-aminosuberic acid II. Synthesis of deamino-dicarba-eel-calcitonin sequence 1-9. PubMed: 1,6-Aminosuberic acid analogs of lysine- and arginine-vasopressin and -vasotocin. Synthesis and biological properties. PubMed: [Tritium-labeled reactive analogs of [1,6-alpha-aminosuberic acid, 8-arginine] vasopressin (deamino-dicarba-[8-arginine] vasopressin. synthesis and properties]. PubMed: [1,6-alpha-aminosuberic acid,3-(p-azidophenylalanine), 8-arginine] vasopressin as a photoaffinity label for renal vasopressin receptors: an evaluation. PubMed: [1,6-alpha-aminosuberic acid, 3-(p-azidophenylalanine), 8-arginine] vasopressin: a new photoaffinity label for hydroosmotic hormone receptors. Characterization of the ligand and irreversible stimulation of hydroosmotic water flow in toad bladder by photoaffinity labeling. PubMed: Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. PubMed: Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax. PubMed: Amino acids with aryl-keto function in their side chains. PubMed: Tandem enzymatic resolution yielding L-alpha-aminoalkanedioic acid omega-esters. PubMed: Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord. PubMed: A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. PubMed: Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity. PubMed: Potent antimalarial activity of histone deacetylase inhibitor analogues. PubMed: Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity. PubMed: Conformational studies of oxytocin analogues with different ring sizes. I. Circular dichroism. PubMed: Enzymatic semisynthesis of dicarba analogs of calcitonin. PubMed: Neurohypophyseal hormones, analogs, and fragments: their effect on puromycin-induced amnesia. PubMed: Aliphatic amino diacid Asu functions as an effective mimic of Tyr(SO3H) in sulfakinins for myotropic and food intake-inhibition activity in insects. PubMed: [Asu(1,7)E-CT, an analog of eel calcitonin. A comparative study in man with reference to other synthetic calcitonins]. PubMed: Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies. PubMed: Investigation of cyclic depsipeptides by fast atom bombardment-mass spectrometry. PubMed: Analogues of the cytostatic and antimitogenic agents chlamydocin and HC-toxin: synthesis and biological activity of chloromethyl ketone and diazomethyl ketone functionalized cyclic tetrapeptides. PubMed: [Effect of Asu-AVT on electroacupuncture (EA) analgesia]. PubMed: A dicarba analog of beta-atrial natriuretic peptide (beta-ANP) inhibits guanosine 3',5'-cyclic monophosphate production induced by alpha-ANP in cultured rat vascular smooth muscle cells. PubMed: Calcitonin binding and degradation by two cultured human breast cancer cell lines (MCF 7 and T 47D).