hydroxypropyl methylcellulose phthalate
cellulose phthalate hydroxypropyl methyl ether
Identification
| Name | hydroxypropyl methylcellulose phthalate |
| CAS Number | 9050-31-1 |
| FDA UNII | G4U024CQK6 |
| MDL Number | MFCD00147216 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | oral care agents |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | oral-rat LD > 15000 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | oral care agents |
| Recommendation for hydroxypropyl methylcellulose phthalate usage levels up to | not for fragrance use. |
| Recommendation for hydroxypropyl methylcellulose phthalate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
cellulose phthalate hydroxypropyl methyl ether
HP 55
HP 55 F
hydroxypropyl methyl cellulose phthalate
2-
hydroxypropyl methyl cellulose phthalate
hydroxypropylmethylcellulose phthalate
PubMed:
Enteric-coated capsule containing β-galactosidase-loaded polylactic acid nanocapsules: enzyme stability and milk lactose hydrolysis under simulated gastrointestinal conditions.
PubMed:
pH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: in vitro and in vivo evaluation.
PubMed:
Instantaneous enteric nano-encapsulation of omeprazole: pharmaceutical and pharmacological evaluation.
PubMed:
Stability and viscoelasticity of magneto-Pickering foams.
PubMed:
Preparation, characterization, and evaluation in vivo of Ins-SiOâ-HP55 (insulin-loaded silica coating HP55) for oral delivery of insulin.
PubMed:
Highly efficient miniaturized coprecipitation screening (MiCoS) for amorphous solid dispersion formulation development.
PubMed:
A novel once daily microparticulate dosage form comprising lansoprazole to prevent nocturnal acid breakthrough in the case of gastro-esophageal reflux disease: preparation, pharmacokinetic and pharmacodynamic evaluation.
PubMed:
A practical method to predict physical stability of amorphous solid dispersions.
PubMed:
Solvent mediated microstructures and release behavior of insulin from pH-sensitive nanoparticles.
PubMed:
HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin.
PubMed:
Development of enteric submicron particle formulation of papain for oral delivery.
PubMed:
Preparation and characterization of a coacervate extended-release microparticulate delivery system for Lactobacillus rhamnosus.
PubMed:
Development of enteric submicron particles formulation of α-amylase for oral delivery.
PubMed:
Magnetically responsive pickering foams.
PubMed:
Preparation and characterization of tablet formulation based on solid dispersion of glimepiride and poly(ester amide) hyperbranched polymer.
PubMed:
Comparison of HPMC based polymers performance as carriers for manufacture of solid dispersions using the melt extruder.
PubMed:
Enteric microsphere formulations of papain for oral delivery.
PubMed:
Differences in crystallization rate of nitrendipine enantiomers in amorphous solid dispersions with HPMC and HPMCP.
PubMed:
Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery.
PubMed:
Adsorption and desorption of Sr(II) ions in the gels based on polysaccharide derivates.
PubMed:
Quality by design: optimization of a liquid filled pH-responsive macroparticles using Draper-Lin composite design.
PubMed:
Development of tablets containing probiotics: Effects of formulation and processing parameters on bacterial viability.
PubMed:
Development and in vitro evaluation of pantoprazole-loaded microspheres.
PubMed:
Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: in vitro and in vivo studies.
PubMed:
Preparation of rapidly disintegrating tablets containing itraconazole solid dispersions.
PubMed:
Influence of water soluble additives and HPMCP on drug release from Surelease-coated pellets containing tamsulosin hydrochloride.
PubMed:
Mechanistic investigations of phase behavior in Eudragit E blends.
PubMed:
Statistical optimization of tamsulosin hydrochloride controlled release pellets coated with the blend of HPMCP and HPMC.
PubMed:
Development and optimization of a novel oral controlled delivery system for tamsulosin hydrochloride using response surface methodology.
PubMed:
Optimization of tamsulosin hydrochloride controlled release pellets coated with Surelease and neutralized HPMCP.
PubMed:
Designing a self-associated cationic polymer for enhanced compatibility, palatability, and gastric release of cefuroxime axetil.
PubMed:
Blends of reverse enteric polymer with Enteric and pH-independent polymers: mechanistic investigations for tailoring drug release.
PubMed:
Solid dispersions of itraconazole and enteric polymers made by ultra-rapid freezing.
PubMed:
Particle design of three-component system for sustained release using a 4-fluid nozzle spray-drying technique.
PubMed:
Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery.
PubMed:
Colonic drug delivery: influence of cross-linking agent on pectin beads properties and role of the shell capsule type.
PubMed:
A new solution for a chronic problem; aqueous enteric coating.
PubMed:
Pharmacokinetics of two novel bicalutamide formulations in healthy male volunteers.
PubMed:
Preparation and evaluation of solid dispersion for nitrendipine-carbopol and nitrendipine-HPMCP systems using a twin screw extruder.
PubMed:
Preparation of enteric microsphere of oleanolic acid dihemiphthalate sodium by salting-out action using spherical crystallization technique.
PubMed:
[Evaluation of in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method].
PubMed:
Preparation and evaluation of pH-dependent gradient-release pellets for TCM.
PubMed:
A novel pH-dependent gradient-release delivery system for nitrendipine II. Investigations of the factors affecting the release behaviors of the system.
PubMed:
[Relative bioavailability of cyclosporine A-loaded hydroxypropyl methylcellulose phthalate nanoparticles for oral administration in rats].
PubMed:
A novel pH-dependent gradient-release delivery system for nitrendipine: I. Manufacturing, evaluation in vitro and bioavailability in healthy dogs.
PubMed:
Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration.
PubMed:
[Influence of suspending agents on relative bioavailability of cyclosporine A-loaded HPMCP nanoparticles for oral administration to rats].
PubMed:
Gastrointestinal absorption enhancement of insulin by administration of enteric microspheres and SNAC to rats.
PubMed:
Molecular weight determination of hypromellose phthalate (HPMCP) using size exclusion chromatography with a multi-angle laser light scattering detector.
PubMed:
Swelling and drug release behavior of tablets coated with aqueous hydroxypropyl methylcellulose phthalate (HPMCP) nanoparticles.
PubMed:
Physical stability and enthalpy relaxation of drug-hydroxypropyl methylcellulose phthalate solvent change co-precipitates.
PubMed:
Factors affecting incorporation of drug into solid solution with HPMCP during solvent change co-precipitation.
PubMed:
Solvent change co-precipitation with hydroxypropyl methylcellulose phthalate to improve dissolution characteristics of a poorly water-soluble drug.
PubMed:
The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder.
PubMed:
Retention and transit of intestinal mucoadhesive films in rat small intestine.
PubMed:
Evaluation of an intestinal pressure-controlled colon delivery capsules prepared by a dipping method.
PubMed:
Drug particle size influence on enteric beads produced by a droplet extrusion/precipitation method.
PubMed:
Design, optimization and evaluation of domperidone coevaporates.
PubMed:
[Evaluation of film forming properties of a hydroxypropylmethylcellulose phthalate (HP 55) pseudolatex].
PubMed:
Design of a "microbicide" for prevention of sexually transmitted diseases using "inactive" pharmaceutical excipients.
PubMed:
Influence of aqueous coatings on the stability of enteric coated pellets and tablets.
PubMed:
Improving the oral bioavailability of albendazole in rabbits by the solid dispersion technique.
PubMed:
Characterization of impurities formed by interaction of duloxetine HCl with enteric polymers hydroxypropyl methylcellulose acetate succinate and hydroxypropyl methylcellulose phthalate.
PubMed:
Passage of chicken egg yolk antibody treated with hydroxypropyl methylcellulose phthalate in the gastrointestinal tract of calves.
PubMed:
The bioavailability of oral dosage forms of a new HIV-1 protease inhibitor, KNI-272, in beagle dogs.
PubMed:
Oral absorption improvement of poorly soluble drug using solid dispersion technique.
PubMed:
Preparation, characterization and in vitro drug release of poly-epsilon-caprolactone and hydroxypropyl methylcellulose phthalate ketoprofen loaded microspheres.
PubMed:
Improved oral absorption of enteric coprecipitates of a poorly soluble drug.
PubMed:
Influence of physical aging on mechanical properties of polymer free films: the prediction of long-term aging effects on the water permeability and dissolution rate of polymer film-coated tablets.
PubMed:
A polymer carrier system for taste masking of macrolide antibiotics.
PubMed:
Comparison of enteric-coated capsules and liquid formulation of Ty21a typhoid vaccine in randomised controlled field trial.
PubMed:
The effect of physical aging on the dissolution rate of anionic polyelectrolytes.
PubMed:
Influence of relative humidity on the adhesive properties of a model interactive system.
PubMed:
[Effect of film formers and plasticizers on the stability of resistance and disintegration behavior. 4. Pharmaceutical-technological and analytical studies of gastric juice-resistant commercial preparations].
PubMed:
[Fabrication and coating of microgranules of acetylsalicylic acid: use of HP55].
PubMed:
[Analysis of traces of organic solvents in microgranules of acetylsalicylic acid coated with HP55].
PubMed:
Sustained release of nifedipine from granules.
PubMed:
Radiotelemetric method for evaluating enteric coatings in vivo.
PubMed:
Dosage form design for improvement of bioavailability of levodopa VI: formulation of effervescent enteric-coated tablets.