isoamyl amine

isopentylamine

CAS: 107-85-7 C5 H13 N MW: 87.16561000 ammoniacal

Identification

Nameisoamyl amine
IUPAC3-methylbutan-1-amine
CAS Number107-85-7
EINECS203-526-0
FDA UNIILPO0L33SHY
Molecular FormulaC5 H13 N
Molecular Weight87.16561000
MDL NumberMFCD00008203
Nikkaji NumberJ95.661I
Beilstein1209230
CoE Number512

Regulatory

JECFA Food Flavoring1587 isopentylamine
DG SANTE Food Flavourings11.001 3-methylbutylamine
FEMA Number3219
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)107-85-7 ; ISOPENTYLAMINE

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.74700 to 0.75300 @ 25.00 °C.
Pounds per Gallon - (est). 6.216 to 6.266
Refractive Index 1.40500 to 1.41100 @ 20.00 °C.
Melting Point -60.00 °C. @ 760.00 mm Hg
Boiling Point 95.00 to 97.00 °C. @ 760.00 mm Hg
Vapor Pressure 51.112999 mmHg @ 25.00 °C. (est)
Vapor Density 3 ( Air = 1 )
Flash Point 62.00 °F. TCC ( 16.67 °C. )
logP (o/w) 1.410 (est)
Soluble in alcohol
Similar Items note

Organoleptic Properties

Odor Description at 0.10 % in propylene glycol.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for isoamyl amine usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)24.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)0.07 (μg/capita/day)
Threshold of Concern1800 (μg/person/day)
Structure ClassI
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

FR chocolate FL seafood

Natural Occurrence

apple fruit PMC arum dioscoridis arum italicum banana fruit beef boiled beef PMC beer PMC bread wheat bread PMC caviar PMC cheese bleu cheese PMC cheese cheddar cheese PMC cheese swiss cheese PMC cocoa coffee PMC corn sprout dragonwort elder black elder flower elder black elder plant grape grape fruit juice hydrosme rivieri kale PMC mushroom porcini mushroom PMC pork fried pork PMC rhubarb PMC rutabaga sauromatum guttatum spinach leaf tomato truffle wine red wine wine white wine

Synonyms

1- amino-3-methyl butane 1- amino-3-methylbutane 1- aminoisopentane iso amylamine monoiso amylamine 1- butanamine, 3-methyl- iso butyl carbyl amine iso butyl carbylamine butylamine, 3-methyl- 3,3- dimethyl propyl amine 3,3- dimethylpropylamine leucamine 3- methyl butyl amine 3- methyl-1-butanamine 3- methyl-butan-1-amine 3- methylbutan-1-amine 3- methylbutanamine 3- methylbutyl amine 3- methylbutylamine iso pentyl amine iso pentylamine monoiso pentylamine propylamine, 3,3-dimethyl- iso valeryl amine Info: aliphatic and aromatic amines and amides PubMed: Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov. PubMed: Synthesis of methylisoamylnitrosamine from isoamylamine by fungi (Fusarium moniliforme). PubMed: Synthesis of nitrosomethylisoamylamine from isoamylamine and sodium nitrite by fungi. PubMed: Nitrogen fertilisation increases biogenic amines and amino acid concentrations in Vitis vinifera var. Riesling musts and wines. PubMed: [Studies on the synthesis of two new nitrosamines (NMAMBA and NMAMPA) from isoamylamine and sodium nitrite by fungi]. PubMed: The deamination of isoamylamine by monamine oxidase in mitochondrial preparations from rat liver and heart: a comparison with phenylethylamine. PubMed: Impact of Gram-negative bacteria in interaction with a complex microbial consortium on biogenic amine content and sensory characteristics of an uncooked pressed cheese. PubMed: Levels of histamine and other biogenic amines in high-quality red wines. PubMed: Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity. PubMed: Validation of a method for the analysis of biogenic amines: histamine instability during wine sample storage. PubMed: Study of the naphthalene-2,3-dicarboxaldehyde pre-column derivatization of biogenic mono- and diamines in mixture and fluorescence-HPLC determination. PubMed: E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors. PubMed: Diversity and assessment of potential risk factors of Gram-negative isolates associated with French cheeses. PubMed: Metabolic profiling of the protozoan parasite Entamoeba invadens revealed activation of unpredicted pathway during encystation. PubMed: Identification of puberty-accelerating pheromones in male mouse urine. PubMed: Gas chromatography-mass spectrometry assessment of amines in Port wine and grape juice after fast chloroformate extraction/derivatization. PubMed: Nakijiquinones J--R, sesquiterpenoid quinones with an amine residue from okinawan marine sponges. PubMed: Autophagy in tobacco BY-2 cells cultured under sucrose starvation conditions: isolation of the autolysosome and its characterization. PubMed: Analysis of puberty-accelerating pheromones. PubMed: Trace amine-associated receptors are olfactory receptors in vertebrates. PubMed: High-precision position-specific isotope analysis of 13C/12C in leucine and methionine analogues. PubMed: Seasonal changes in plasma concentrations of cecum-derived amines in clinically normal ponies and ponies predisposed to laminitis. PubMed: Gas chromatographic analysis of bacterial amines as their free bases. PubMed: Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c. PubMed: Production of amines in equine cecal contents in an in vitro model of carbohydrate overload. PubMed: Semicarbazide-sensitive amine oxidase (SSAO) of the rat aorta. Interactions with some naturally occurring amines and their structural analogues. PubMed: Interaction of 11 cisplatin analogues with DNA: characteristic pattern of damage with monofunctional analogues. 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PubMed: THE METABOLISM OF THE ISCHEMIC KIDNEY : I. THE RESPIRATION AND THE OXIDASE ACTIVITY OF THE ISCHEMIC KIDNEY. PubMed: Ion-trap versus time-of-flight mass spectrometry coupled to capillary electrophoresis to analyze biogenic amines in wine. PubMed: Separation and conductimetric detection of C1-C7 aliphatic monocarboxylic acids and C1-C7 aliphatic monoamines on unfunctionized polymethacrylate resin columns. PubMed: Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets. PubMed: Attractants fromStaphylococcus aureus cultures for Mexican fruit fly,Anastrepha ludens. PubMed: Gas liquid chromatography of amines produced by the Enterobacteriaceae. PubMed: [Evidence of synthesizing secondary amines from primary amines by fungi--microbiological production of methylisoamylamine and piperidine]. PubMed: Environmental effects on charge densities of biologically active molecules: do molecule crystal environments indeed approximate protein surroundings? PubMed: Michael acceptors as cysteine protease inhibitors. PubMed: Effect of cysteine protease inhibitor Ep-475 on TNF-alpha-independent cyclophosphamide-induced apoptosis in mouse lymphosarcoma LS cells. PubMed: Involvement of calpain in osteoclastic bone resorption. PubMed: Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site. PubMed: Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway. PubMed: Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition. PubMed: Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex. PubMed: Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa. PubMed: Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors. PubMed: Striated muscle calcium-stimulated cysteine protease (calpain-like) activity promotes myeloperoxidase activity with exercise. PubMed: A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophy. PubMed: m-calpain in rat growth plate chondrocyte cultures: its involvement in the matrix mineralization process. PubMed: Retraction of cultured endothelial cell monolayer by human breast cancer cells, MCF-7. PubMed: Determination of a cysteine protease inhibitor and its ethyl ester in mouse serum and muscle by liquid chromatography-mass spectrometry. PubMed: Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain. PubMed: Effects of selective inhibition of cathepsin B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro. PubMed: Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases. PubMed: A comparison between the binding modes of a substrate and inhibitor to papain as observed in complex crystal structures. PubMed: Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. PubMed: Diabetic state-induced activation of calcium-activated neutral proteinase in mouse skeletal muscle. PubMed: Differences in substrate specificities for cysteine proteinases used in blood group serology, and the use of bromelain in a two-phase inhibitor technique. PubMed: Cathepsin L--a latent proteinase in guinea pig sperm. PubMed: The role of increased proteolysis in the atrophy and arrest of proliferation in serum-deprived fibroblasts. PubMed: Two-step mechanism of myofibrillar protein degradation in acute plasmocid-induced muscle necrosis. PubMed: Limited benefit to genetically dystrophic chickens from a synthetic proteinase inhibitor: Ep475. PubMed: A novel type of autophagy occurs together with vacuole genesis in miniprotoplasts prepared from tobacco culture cells. PubMed: Effect of a cysteine protease inhibitor on Fasciola hepatica (liver fluke) fecundity, egg viability, parasite burden, and size in experimentally infected sheep. PubMed: Involvement of calpain and synaptotagmin Ca2+ sensors in hormone secretion from excitable endocrine cells. PubMed: Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase. PubMed: Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation. PubMed: A homologue of cathepsin L identified in conditioned medium from Sf9 insect cells. PubMed: Entamoeba histolytica: correlation of assessment methods to measure erythrocyte digestion, and effect of cysteine proteinases inhibitors in HM-1:IMSS and HK-9:NIH strains. PubMed: Differential effects of calpain inhibitors on hypertrophy of cardiomyocytes. PubMed: Participation of intracellular cysteine proteinases, in particular cathepsin B, in degradation of collagen in periosteal tissue explants. PubMed: Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain. PubMed: Effect of Ep475 on changes induced by calcium activated neutral protease on erythrocyte membrane. PubMed: The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators. PubMed: The ATP-independent pathway in red blood cells that degrades oxidant-damaged hemoglobin. PubMed: Ester and amide derivatives of E64c as inhibitors of platelet calpains. PubMed: Involvement of reactive oxygen species in post-ischaemic flap necrosis and its prevention by antioxidants. PubMed: Effects of the calpain inhibitor E64-d on platelet activation responses. PubMed: Isolation of rod outer segments on Percoll gradients: effect of specific protease inhibition. PubMed: Mode of binding of E-64-c, a potent thiol protease inhibitor, to papain as determined by X-ray crystal analysis of the complex. PubMed: Morphological, physiological and biochemical alterations in livers of rodents induced by protease inhibitors: a comparison with old livers. PubMed: Autodegradation of lysosomal cysteine proteinases. 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