hematein
3,4,10,6a-tetrahydroxy-7,6a-dihydroindeno[2,1-c]chroman-9-one
Identification
| Name | hematein |
| CAS Number | 475-25-2 |
| EINECS | 207-492-8 |
| FDA UNII | 88Q1SYD10B |
| Molecular Formula | C16 H12 O6 |
| Molecular Weight | 300.26684000 |
| MDL Number | MFCD00036187 |
| Nikkaji Number | J12.119C |
| Beilstein | 093039 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 250.00 °C. @ 760.00 mm Hg |
| Boiling Point | 753.10 °C. @ 760.00 mm Hg (est) |
| Flash Point | 552.00 °F. TCC ( 289.00 °C. ) (est) |
| logP (o/w) | 0.560 (est) |
| Soluble in | water, 600 mg/L @ 20 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | coloring agents |
| Recommendation for hematein usage levels up to | not for fragrance use. |
| Recommendation for hematein flavor usage levels up to | not for flavor use. |
Glentham Life Sciences Ltd
The Chemical, Biochemical & Research Essentials Supplier
Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.
Potential Uses
Natural Occurrence
Synonyms
benz(b)indeno(1,2-d)pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy-
benz[b]indeno[1,2-d]pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy-
6a,7-
dihydro-3,4,6a,10-tetrahydroxybenz(b)indeno(1,2-d)pyran-9(6H)-one
6a,7-
dihydro-3,4,6a,10-tetrahydroxybenz[b]indeno[1,2-d]pyran-9(6H)-one
haematein
hematine
hydroxybrasilein
hydroxybrazilein
3,4,6a,10-
tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one
3,4,6a,10-
tetrahydroxy-6a,7-dihydrobenz(b)indeno(1,2-d)pyran-9(6H)-one
3,4,6a,10-
tetrahydroxy-6a,7-dihydroindeno[2,1-c]chromen-9(6H)-one
3,4,10,6a-
tetrahydroxy-7,6a-dihydroindeno[2,1-c]chroman-9-one
PubMed:
[Application of fluorescence probe marked by quantum dots to detect early submandibular lymph node metastasis in a nude mouse model].
PubMed:
A low detection limit penicillin biosensor based on single graphene nanosheets preadsorbed with hematein/ionic liquids/penicillinase.
PubMed:
[Effects of periodontal mechanical therapy with local and systemic drugs on carotid artery and serum high-sensitivity C-reactive protein in rats with chronic periodontitis associated with atherosclerosis].
PubMed:
Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model.
PubMed:
[A comparative study on apexification using different kinds of materials in dogs].
PubMed:
[The effect of modified bone morphogenetic protein-2 polylactic acid nanospheres sustained-release system on promoting mandibular defect repair].
PubMed:
The hypoglycemic effect of the kelp on diabetes mellitus model induced by alloxan in rats.
PubMed:
A new use for an old method: the Woelcke myelin stain for counting degenerating neurons in the brain of mice following status epilepticus.
PubMed:
Embolization of hepatocellular carcinoma with drug-eluting beads: doxorubicin tissue concentration and distribution in patient liver explants.
PubMed:
[Pulp revascularization of immature anterior teeth with apical periodontitis].
PubMed:
An enzyme-free highly glucose-specific assay using self-assembled aminobenzene boronic acid upon polyelectrolytes electrospun nanofibers-mat.
PubMed:
An amperometric penicillin biosensor with enhanced sensitivity based on co-immobilization of carbon nanotubes, hematein, and beta-lactamase on glassy carbon electrode.
PubMed:
Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model.
PubMed:
Nuclear staining with alum hematoxylin.
PubMed:
Hematein chelates of unusual metal ions for tinctorial histochemistry.
PubMed:
Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications.
PubMed:
A special issue devoted to hematoxylin, hematein, and hemalum.
PubMed:
Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.
PubMed:
An amperometric urea biosensor based on covalently immobilized urease on an electrode made of hyperbranched polyester functionalized gold nanoparticles.
PubMed:
Urea biosensor based on amperometric pH-sensing with hematein as a pH-sensitive redox mediator.
PubMed:
Negative ion electrospray mass spectrometry of neoflavonoids.
PubMed:
The precise location and nature of the nerves to the male human urethra: histological and immunohistochemical studies with three-dimensional reconstruction.
PubMed:
An amperometric urea biosensor based on covalent immobilization of urease onto an electrochemically prepared copolymer poly (N-3-aminopropyl pyrrole-co-pyrrole) film.
PubMed:
[The uteropelvic junction in children: from the clinical problems to the morphogenetic approach].
PubMed:
Anatomical histological and mesoscopic study of the adipose tissue of the orbit.
PubMed:
[Organization and innervation of striated muscle fibers of the striated sphincter in the rat].
PubMed:
Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-kappaB-dependent inflammatory mediators in hyperlipidemic mice.
PubMed:
Pharmacological action and therapeutic effects of glutathione on hypokinetic spermatozoa for enzymatic-dependent pathologies and correlated genetic aspects.
PubMed:
Determination of ATP via the photochemical generation of hydrogen peroxide using flow injection luminol chemiluminescence detection.
PubMed:
Staining of intestinal protozoa with Heidenhain's iron hematoxylin.
PubMed:
Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression.
PubMed:
Comparison of historic Grübler dyes with modern counterparts.
PubMed:
Hematein inhibits tumor necrotic factor-alpha-induced vascular cell adhesion molecule-1 and NF-kappaB-dependent gene expression in human vascular endothelial cells.
PubMed:
Morphometric study of the upper intercostal nerves: practical application for neurotizations in traumatic brachial plexus palsies.
PubMed:
[VCS microclip anastomosis on blood vessels of less than 2 millimeters in diameter. Preliminary experimental study in the rat].
PubMed:
Hematoxylin staining in quantitative DNA cytometry: an image analysis study.
PubMed:
A quick-mixed aluminum hematoxylin stain.
PubMed:
New investigations on hematoxylin, hematein, and hematein-aluminium complexes. II. Hematein-aluminium complexes and hemalum staining.
PubMed:
New investigations on hematoxylin, hematein, and hematein-aluminium complexes. I. Spectroscopic and physico-chemical properties of hematoxylin and hematein.
PubMed:
[Colo-rectal spirochetosis: is it an anatomo-pathologic entity?].
PubMed:
[Edema inhibiting effect of indenochromene derivatives from natural sources].
PubMed:
Localization of phospholipids in human catecholamine neurons with Baker's acid haematein.
PubMed:
[Mechanisms of the inhibition of Fe2+-induced oxidation of phosphatidylcholine by polyhydroxynaphthoquinones].
PubMed:
Effects of the metal salts on the staining of elastic fibers with hematein.
PubMed:
Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation.
PubMed:
Effect of formalin pigment removal on peroxidase-antiperoxidase immunoperoxidase technique.
PubMed:
Application of current chemical concepts to metal-hematein and -brazilein stains.
PubMed:
A histological assessment of the four-day subrenal capsule assay (SRCA).
PubMed:
[Cellular aspects of the aging of the articular cartilage. II. Condylar cartilage with fissured surface taken from normal and arthritic knees].
PubMed:
A four-day subrenal capsule assay for testing the effectiveness of anticancer drugs against human tumors.
PubMed:
Studies on Papanicolaou staining. III. Quantitative investigations of orangeophilia and cyanophilia.
PubMed:
Papanicolaou staining--a review.
PubMed:
Chemical aspects of santalin as a histological stain.
PubMed:
The effect of sexual hormones on the lipid and proteinaceous secretion of the rat preputial sebaceous gland.
PubMed:
Studies on Papanicolaou staining. II. Quantitation of dye components bound to cervical cells.
PubMed:
On the mechanism of Verhoeff's elastica stain: a convenient stain for myelin sheaths.
PubMed:
Odontogenic keratocysts: a clinical and histological study with special reference to enzyme histochemistry.
PubMed:
Assessment of the heart by histochemical and birefringence techniques as compared with ventricular function tests.
PubMed:
On elastic fibers stain with hematein and its staining mechanism.
PubMed:
Histochemical studies on metachromatic mucin stain with hematein.
PubMed:
[Histological application of hematein by means of Arshid's method with special reference to staining of mucosubstances, elastic fibers and collagenous fibers].
PubMed:
[Hematin treatment of porphyric neuropathy].
PubMed:
[Myocardium in valvular cardiopathies. Ultrastructural and histoenzymological changes. Functional correlations].
PubMed:
[On the hematein staining--comparative studies with hematoxylin staining (author's transl)].
PubMed:
Histochemical and structural changes in human myocardial cells after cardiopulmonary bypass.
PubMed:
Thin layer chromatography of certain preformed metal complex dyes used in biological staining.
PubMed:
Effects of additives on alum hematoxylin staining solutions.
PubMed:
Lipid droplets in the heart interstitium: concentration and distribution.
PubMed:
Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants.
PubMed:
A simple assay procedure for mixtures of hematoxylin and hematein.
PubMed:
Cytochemical reactions of human leprosy bacilli and mycobacteria: ultrastructural implications.
PubMed:
A technique combining Baker's acid hematein and Hadjioloff's hydrotropic sudan 3 stains for identification of choline-containing phospholipids within the same tissue section.
PubMed:
The staining and chromium binding of rat brain tissue and of lipids in model systems subjected to Baker's acid hematein technique.
PubMed:
Assaying actual hematein content of commercial hematoxylins and hemateins.
PubMed:
Studies on metallochromic indicators-III Hematoxylin and hematein.
PubMed:
The acid hematein stain and myocardial damage.
PubMed:
[Comparative studies on phospholipid demonstration with Baker's acid hematein test and the method of Bourgeois and Hubbard].
PubMed:
[Histochemical studies with the acid hematein test according to Baker on pathologically changed skin. VI. Adipose tissue tumors and fat cells in other tumors].
PubMed:
[HISTOCHEMICAL STUDIES WITH THE BAKER ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICAL SKIN. IV. NEVUS CELL NEVUS, PREBLASTOMATOUS MELANOSIS AND MELANOCYTE BLASTOMA].
PubMed:
On the mechanism of sequence iron-hematein stains.
PubMed:
The reaction of unsaturated fats with the acid hematein test.
PubMed:
[HISTOCHEMICAL STUDIES WITH BAKER'S ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. 3. DENDRITE CELLS OF THE EPITHELIUM].
PubMed:
[HISTOCHEMICAL STUDIES WITH BAKER'S ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. II. MOLLUSCUM CONTAGIOSUM, VERRUCA VULGARIS AND CONDYLOMA ACUMINATUM].
PubMed:
[HISTOCHEMICAL STUDIES WITH THE BAKER ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. I. NORMAL SKIN].
PubMed:
A SIMPLIFIED ACID HEMATEIN TEST FOR PHOSPHOLIPIDS.
PubMed:
Experimental and cytological studies of pineal cells staining with acid hematein in the rat (Rattus norvegicus).
PubMed:
Acid hematein staining of uterine neoplastic tissues.
PubMed:
Cytochemical studies on tumor cells. III. Two types of tumor cells as revealed by the acid hematein test.
PubMed:
Cytochemical studies on tumor cells. II. Localization of phospholipids in normal and neoplastic tissues, as revealed by the acid hematein test.