3,4,10,6a-tetrahydroxy-7,6a-dihydroindeno[2,1-c]chroman-9-one

CAS: 475-25-2 C16 H12 O6 MW: 300.26684000

Identification

Namehematein
CAS Number475-25-2
EINECS207-492-8
FDA UNII88Q1SYD10B
Molecular FormulaC16 H12 O6
Molecular Weight300.26684000
MDL NumberMFCD00036187
Nikkaji NumberJ12.119C
Beilstein093039

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 250.00 °C. @ 760.00 mm Hg
Boiling Point 753.10 °C. @ 760.00 mm Hg (est)
Flash Point 552.00 °F. TCC ( 289.00 °C. ) (est)
logP (o/w) 0.560 (est)
Soluble in water, 600 mg/L @ 20 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycoloring agents
Recommendation for hematein usage levels up tonot for fragrance use.
Recommendation for hematein flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

benz(b)indeno(1,2-d)pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy- benz[b]indeno[1,2-d]pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy- 6a,7- dihydro-3,4,6a,10-tetrahydroxybenz(b)indeno(1,2-d)pyran-9(6H)-one 6a,7- dihydro-3,4,6a,10-tetrahydroxybenz[b]indeno[1,2-d]pyran-9(6H)-one haematein hematine hydroxybrasilein hydroxybrazilein 3,4,6a,10- tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one 3,4,6a,10- tetrahydroxy-6a,7-dihydrobenz(b)indeno(1,2-d)pyran-9(6H)-one 3,4,6a,10- tetrahydroxy-6a,7-dihydroindeno[2,1-c]chromen-9(6H)-one 3,4,10,6a- tetrahydroxy-7,6a-dihydroindeno[2,1-c]chroman-9-one PubMed: [Application of fluorescence probe marked by quantum dots to detect early submandibular lymph node metastasis in a nude mouse model]. PubMed: A low detection limit penicillin biosensor based on single graphene nanosheets preadsorbed with hematein/ionic liquids/penicillinase. PubMed: [Effects of periodontal mechanical therapy with local and systemic drugs on carotid artery and serum high-sensitivity C-reactive protein in rats with chronic periodontitis associated with atherosclerosis]. PubMed: Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. PubMed: [A comparative study on apexification using different kinds of materials in dogs]. PubMed: [The effect of modified bone morphogenetic protein-2 polylactic acid nanospheres sustained-release system on promoting mandibular defect repair]. PubMed: The hypoglycemic effect of the kelp on diabetes mellitus model induced by alloxan in rats. PubMed: A new use for an old method: the Woelcke myelin stain for counting degenerating neurons in the brain of mice following status epilepticus. PubMed: Embolization of hepatocellular carcinoma with drug-eluting beads: doxorubicin tissue concentration and distribution in patient liver explants. PubMed: [Pulp revascularization of immature anterior teeth with apical periodontitis]. PubMed: An enzyme-free highly glucose-specific assay using self-assembled aminobenzene boronic acid upon polyelectrolytes electrospun nanofibers-mat. PubMed: An amperometric penicillin biosensor with enhanced sensitivity based on co-immobilization of carbon nanotubes, hematein, and beta-lactamase on glassy carbon electrode. PubMed: Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model. PubMed: Nuclear staining with alum hematoxylin. PubMed: Hematein chelates of unusual metal ions for tinctorial histochemistry. PubMed: Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications. PubMed: A special issue devoted to hematoxylin, hematein, and hemalum. PubMed: Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library. PubMed: An amperometric urea biosensor based on covalently immobilized urease on an electrode made of hyperbranched polyester functionalized gold nanoparticles. PubMed: Urea biosensor based on amperometric pH-sensing with hematein as a pH-sensitive redox mediator. PubMed: Negative ion electrospray mass spectrometry of neoflavonoids. PubMed: The precise location and nature of the nerves to the male human urethra: histological and immunohistochemical studies with three-dimensional reconstruction. PubMed: An amperometric urea biosensor based on covalent immobilization of urease onto an electrochemically prepared copolymer poly (N-3-aminopropyl pyrrole-co-pyrrole) film. PubMed: [The uteropelvic junction in children: from the clinical problems to the morphogenetic approach]. PubMed: Anatomical histological and mesoscopic study of the adipose tissue of the orbit. PubMed: [Organization and innervation of striated muscle fibers of the striated sphincter in the rat]. PubMed: Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-kappaB-dependent inflammatory mediators in hyperlipidemic mice. PubMed: Pharmacological action and therapeutic effects of glutathione on hypokinetic spermatozoa for enzymatic-dependent pathologies and correlated genetic aspects. PubMed: Determination of ATP via the photochemical generation of hydrogen peroxide using flow injection luminol chemiluminescence detection. PubMed: Staining of intestinal protozoa with Heidenhain's iron hematoxylin. PubMed: Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression. PubMed: Comparison of historic Grübler dyes with modern counterparts. PubMed: Hematein inhibits tumor necrotic factor-alpha-induced vascular cell adhesion molecule-1 and NF-kappaB-dependent gene expression in human vascular endothelial cells. PubMed: Morphometric study of the upper intercostal nerves: practical application for neurotizations in traumatic brachial plexus palsies. PubMed: [VCS microclip anastomosis on blood vessels of less than 2 millimeters in diameter. Preliminary experimental study in the rat]. PubMed: Hematoxylin staining in quantitative DNA cytometry: an image analysis study. PubMed: A quick-mixed aluminum hematoxylin stain. PubMed: New investigations on hematoxylin, hematein, and hematein-aluminium complexes. II. Hematein-aluminium complexes and hemalum staining. PubMed: New investigations on hematoxylin, hematein, and hematein-aluminium complexes. I. Spectroscopic and physico-chemical properties of hematoxylin and hematein. PubMed: [Colo-rectal spirochetosis: is it an anatomo-pathologic entity?]. PubMed: [Edema inhibiting effect of indenochromene derivatives from natural sources]. PubMed: Localization of phospholipids in human catecholamine neurons with Baker's acid haematein. PubMed: [Mechanisms of the inhibition of Fe2+-induced oxidation of phosphatidylcholine by polyhydroxynaphthoquinones]. PubMed: Effects of the metal salts on the staining of elastic fibers with hematein. PubMed: Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. PubMed: Effect of formalin pigment removal on peroxidase-antiperoxidase immunoperoxidase technique. PubMed: Application of current chemical concepts to metal-hematein and -brazilein stains. PubMed: A histological assessment of the four-day subrenal capsule assay (SRCA). PubMed: [Cellular aspects of the aging of the articular cartilage. II. Condylar cartilage with fissured surface taken from normal and arthritic knees]. PubMed: A four-day subrenal capsule assay for testing the effectiveness of anticancer drugs against human tumors. PubMed: Studies on Papanicolaou staining. III. Quantitative investigations of orangeophilia and cyanophilia. PubMed: Papanicolaou staining--a review. PubMed: Chemical aspects of santalin as a histological stain. PubMed: The effect of sexual hormones on the lipid and proteinaceous secretion of the rat preputial sebaceous gland. PubMed: Studies on Papanicolaou staining. II. Quantitation of dye components bound to cervical cells. PubMed: On the mechanism of Verhoeff's elastica stain: a convenient stain for myelin sheaths. PubMed: Odontogenic keratocysts: a clinical and histological study with special reference to enzyme histochemistry. PubMed: Assessment of the heart by histochemical and birefringence techniques as compared with ventricular function tests. PubMed: On elastic fibers stain with hematein and its staining mechanism. PubMed: Histochemical studies on metachromatic mucin stain with hematein. PubMed: [Histological application of hematein by means of Arshid's method with special reference to staining of mucosubstances, elastic fibers and collagenous fibers]. PubMed: [Hematin treatment of porphyric neuropathy]. PubMed: [Myocardium in valvular cardiopathies. Ultrastructural and histoenzymological changes. Functional correlations]. PubMed: [On the hematein staining--comparative studies with hematoxylin staining (author's transl)]. PubMed: Histochemical and structural changes in human myocardial cells after cardiopulmonary bypass. PubMed: Thin layer chromatography of certain preformed metal complex dyes used in biological staining. PubMed: Effects of additives on alum hematoxylin staining solutions. PubMed: Lipid droplets in the heart interstitium: concentration and distribution. PubMed: Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants. PubMed: A simple assay procedure for mixtures of hematoxylin and hematein. PubMed: Cytochemical reactions of human leprosy bacilli and mycobacteria: ultrastructural implications. PubMed: A technique combining Baker's acid hematein and Hadjioloff's hydrotropic sudan 3 stains for identification of choline-containing phospholipids within the same tissue section. PubMed: The staining and chromium binding of rat brain tissue and of lipids in model systems subjected to Baker's acid hematein technique. PubMed: Assaying actual hematein content of commercial hematoxylins and hemateins. PubMed: Studies on metallochromic indicators-III Hematoxylin and hematein. PubMed: The acid hematein stain and myocardial damage. PubMed: [Comparative studies on phospholipid demonstration with Baker's acid hematein test and the method of Bourgeois and Hubbard]. PubMed: [Histochemical studies with the acid hematein test according to Baker on pathologically changed skin. VI. Adipose tissue tumors and fat cells in other tumors]. PubMed: [HISTOCHEMICAL STUDIES WITH THE BAKER ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICAL SKIN. IV. NEVUS CELL NEVUS, PREBLASTOMATOUS MELANOSIS AND MELANOCYTE BLASTOMA]. PubMed: On the mechanism of sequence iron-hematein stains. PubMed: The reaction of unsaturated fats with the acid hematein test. PubMed: [HISTOCHEMICAL STUDIES WITH BAKER'S ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. 3. DENDRITE CELLS OF THE EPITHELIUM]. PubMed: [HISTOCHEMICAL STUDIES WITH BAKER'S ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. II. MOLLUSCUM CONTAGIOSUM, VERRUCA VULGARIS AND CONDYLOMA ACUMINATUM]. PubMed: [HISTOCHEMICAL STUDIES WITH THE BAKER ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. I. NORMAL SKIN]. PubMed: A SIMPLIFIED ACID HEMATEIN TEST FOR PHOSPHOLIPIDS. PubMed: Experimental and cytological studies of pineal cells staining with acid hematein in the rat (Rattus norvegicus). PubMed: Acid hematein staining of uterine neoplastic tissues. PubMed: Cytochemical studies on tumor cells. III. Two types of tumor cells as revealed by the acid hematein test. PubMed: Cytochemical studies on tumor cells. II. Localization of phospholipids in normal and neoplastic tissues, as revealed by the acid hematein test.