dextro-gamma-tocopherol
2H-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-
Identification
| Name | dextro-gamma-tocopherol |
| IUPAC | (2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol |
| CAS Number | 54-28-4 |
| EINECS | 200-201-5 |
| FDA UNII | 8EF1Z1238F |
| Molecular Formula | C28 H48 O2 |
| Molecular Weight | 416.68896000 |
| MDL Number | MFCD00066529 |
| Nikkaji Number | J213.540J |
| Beilstein | 93072 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 518.10 °C. @ 760.00 mm Hg (est) |
| Flash Point | 403.00 °F. TCC ( 206.00 °C. ) (est) |
| logP (o/w) | 11.440 (est) |
| Soluble in | water, 1.069e-006 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antioxidants |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for dextro-gamma-tocopherol usage levels up to | not for fragrance use. |
| Recommendation for dextro-gamma-tocopherol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2H-1-
benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)-
2H-1-
benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-
(2R(2R*(4R*,8R*)))-3,4-
dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol
(2R)-3,4-
dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
D-gamma-
tocopherol
(2R)-2,7,8-
trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol
(2R)-2,7,8-
trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
(2R)-2,7,8-
trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-6-chromanol
(2R)-2,7,8-
trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
PubMed:
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
PubMed:
Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCα in human microvascular endothelial cells.
PubMed:
Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells.
PubMed:
Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment.
PubMed:
A pharmacological action of vitamin E unrelated to its antioxidant capacity.
PubMed:
Chemopreventive effect of dietary d-alpha-tocopheryl succinate supplementation on precancer colon aberrant crypt formation and vitamin E analogue levels in young and old rats.
PubMed:
Dose-dependent effects of dietary alpha- and gamma-tocopherols on genetic instability in mouse Mutatect tumors.
PubMed:
Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC.
PubMed:
Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells.
PubMed:
The vitamin E nutritional status of rats fed on diets high in fish oil, linseed oil or sunflower seed oil.
PubMed:
NO2-induced DNA single strand breaks are inhibited by antioxidative vitamins in V79 cells.
PubMed:
Mammary transfer of vitamin E in dairy cows.
PubMed:
Mechanisms of absorption, transport and tissue uptake of RRR-alpha-tocopherol and d-gamma-tocopherol in the white rat.
PubMed:
Biopotency of vitamin E in barley.
PubMed:
Relative antioxidant effectiveness of alpha-tocopherol and gamma-tocopherol in iron-loaded rats.
PubMed:
Biological activity of vitamin E compounds and natural materials by the resorption-gestation test, and chemical determination of the vitamin E activity in foods and feeds.
PubMed:
EFFECT OF D-GAMMA-TOCOPHEROL ON THE INCIDENCE OF TERATOGENY IN VITAMIN E-DEFICIENT RATS.