S-(methyl thio) butyrate

methyl thiobutyrate

CAS: 2432-51-1 C5 H10 O S MW: 118.19890000 cheesy musty

Identification

NameS-(methyl thio) butyrate
IUPACS-methyl butanethioate
CAS Number2432-51-1
EINECS219-407-1
FDA UNII2P1E432MYZ
Molecular FormulaC5 H10 O S
Molecular Weight118.19890000
MDL NumberMFCD00009872
Nikkaji NumberJ125.734J
CoE Number2328

Regulatory

JECFA Food Flavoring484 methyl thiobutyrate
DG SANTE Food Flavourings12.032 S-methyl butanethioate
FEMA Number3310
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)2432-51-1 ; METHYL THIOBUTYRATE

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.13500 to 1.13800 @ 25.00 °C.
Pounds per Gallon - (est). 9.444 to 9.469
Refractive Index 1.43200 to 1.43700 @ 20.00 °C.
Boiling Point 142.00 to 143.00 °C. @ 757.00 mm Hg, 38.00 to 40.00 °C. @ 12.00 mm Hg
Acid Value 1.00 max. KOH/g
Vapor Pressure 5.872000 mmHg @ 25.00 °C. (est)
Vapor Density 4.0 ( Air = 1 )
Flash Point 94.00 °F. TCC ( 34.44 °C. )
logP (o/w) 1.878 (est)
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Description
at 0.10 % in propylene glycol.
at 1.00 % in ethyl alcohol.
powerful, sweet cheesy
powerful sweet cheesy, cocoa odour on dilution
Taste Description
at 5.00 ppm.
musty
cheesy

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for S-(methyl thio) butyrate usage levels up to0.0300 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)2.90 (μg/capita/day)
Structure ClassI
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

Advanced Biotech. Inc.

Inspired by Nature

A diverse range of products, all meeting our stringent commitment to quality.

View All Website 973-339-6242 info@adv-bio.com

Alfrebro LLC/ Archer Daniels Midland Company

Let's get reacquainted

Building great taste with aroma chemicals, extracts, and distillates

View All Website 513-539-7373 sforbis@alfrebro.com

Axxence Aromatic GmbH

We bring nature to your flavour

Dedicated to provide the best possible quality and supply service of natural aroma ingredients.

View All Website +49.2822.68561.0 service@axxence.com

Beijing Lys Chemicals Co, LTD.

From Grams to Tons

Fine chemical high-tech company which contains R&D, production, and sales.

View All Website 86-10-68418738 jiayanyong@lyschem.com

Berje Inc.

Where the world comes to its senses

Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.

View All Website 973-748-8980 tlauzurica@berjeinc.com

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

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Charkit Chemical Corporation

The Specialty Chemical Specialists

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View All Website 203-299-3220 sales@charkit.com

Endeavour Specialty Chemicals Ltd

Expertise in high impact aroma chemicals

Endeavour Speciality Chemicals offers high-impact aroma chemicals, at small to medium scale.

View All Website +44 (0)1327 310 079 enquiries@endeavourchem.co.uk

Excellentia International

Ingredients by Nature

Exceptional quality and excellence in meeting our customers requirements.

View All Website 732.749.9840 info@excellentiaint.com

H. Interdonati, Inc.

Innovative products

Because your flavors and fragrances are only as good as their source "Since 1952"

View All Website 800 367-6617 flavorplus@hinterdonati.com

FRUTAROM USA INC,

Flavor & Specialty Ingredients

Your preferred partner for flavour and fragrance success.

View All Website +44 (0) 1429 863 222 Sales.IFFIngredients@iff.com

Indukern, S.A. F&F Ingredients Division

Commitment to quality

Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.

View All Website +34 93 506 91 00 info@indukern.es

Lluch Essence S.L.

A family company dedicated to sales and distribution

Flexibility, availability, price and quality.

View All Website 34 93 379 38 49 web@lluche.com

M&U International LLC

Steady supply & demand

Meeting customers increasing demands at home as well as abroad.

View All Website 908-359-9000 sales@mu-intel.com

Natural Advantage

Manufacturer of natural flavor ingredients

With over 25 years experience in the flavor and food ingredient industries.

View All Website 318-215-1456 info@natadv.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Riverside Aromatics Ltd.

Speciality Aroma Chemicals, Naturals and Synthetics

A specialist supplier of raw materials to the flavour industry.

View All Website +44 (0) 1202 679532 info@riversidearomatics.com

Robertet, Inc.

HOME OF NATURE, SEED TO SCENT

HOME OF NATURE – natural ingredients from the source.

View All Website +1.201.337.7100 info@robertetUSA.com

Robinson Brothers Limited

Providing Excellence in Chemistry

Award-winning UK chemical manufacturer of chemical intermediates and high-impact aroma chemicals.

View All Website +44 (0)121 553 2451 enquiries@robinsonbrothers.co.uk

Sigma-Aldrich

Complete Supply Chain

The perfect blend of products and services that bring your creativity to life.

View All Website 800-244-1173 ff@sial.com

SRS Aromatics Ltd

For over 25 years

Bringing flavour and fragrance into your world.

View All Website +44 (0) 1284 704076 info@srsaromatics.co.uk

Sunaux International

Buy With Confidence

We have industry leading processes and procedures to ensure nothing but the most reliable product.

View All Website 0512-57995626 johnjft@sunaux.com

Synerzine, Inc.

Innovation. Customization. Aroma Ingredients.

Synerzine is a leading supplier of flavor and fragrance ingredients.

View All Website (404) 524-6744 info@synerzine.com

Taytonn ASCC Pte Ltd

Supplying Asia Pacific

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TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Tianjin Danjun International Trade Co., LTD.

Quality Products

We know the Chinese chemical market well.

View All Website +86-15822601686 songshasha@danjunchem.com

R C Treatt and Co Ltd

Innovative ingredient solutions

World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.

View All Website +1 863 668 9500 enquiries@treatt.com

Qingdao Free Trade Zone United International Co Ltd

Quality Products

A partner in your supply chain solution.

View All Website +86-532-83893699 info@unitedint.com

Ernesto Ventós S.A.

Leaders in essence

We employ our five senses to do our job well.

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WholeChem, LLC

Connecting Innovators To the Building Blocks Of the Universe

Custom manufacturer and distributor of specialty ingredients. We make global local.

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Potential Uses

FR berry FL candy FL cheese FL chocolate cocoa FL coffee FL cream FL cream ice cream FL dairy FL fruit tropical fruit FL garlic FL onion FL shellfish FL strawberry FL tomato FL vanilla FL yogurt

Natural Occurrence

cheese cheddar cheese PMC fish oil PMC melon PMC shrimp cooked shrimp PMC strawberry wild strawberry fruit

Synonyms

butanethioic acid S-methyl ester butanethioic acid, S-methyl ester butyric acid, thio-, S-methyl ester cheese butyrate methane thiol butyrate S- methyl butane thioate S- methyl butanethioate methyl thio butyrate methyl thio butyrate 5% in ethanol natural S-( methyl thio) butanoate S- methyl thiobutanoate methyl thiobutyrate S- methyl thiobutyrate methyl thiobutyrate (10% in triacetin) methyl thiobutyrate 5% in ETOH natural methyl thiobutyrate natural methyl thiobutyrate synthetic methyl thiobutyrate, natural 5% in ETOH methyl thiolbutyrate S-( methylthio)butanoate S-( methylthio)butyrate methylthiobutyrate methylthiol n-butyrate thiobutyric acid methyl ester PubMed: Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway. PubMed: Characteristic aroma compounds from different pineapple parts. PubMed: Metabolism of 2-hydroxy-4-(methylthio)butanoate (HMTBA) in lactating dairy cows. PubMed: Identification of new strawberry sulfur volatiles and changes during maturation. PubMed: Methionine-derived metabolites in apoptosis: therapeutic opportunities for inhibitors of their metabolism in chemoresistant cancer cells. PubMed: The tryptophan aminotransferase Tam1 catalyses the single biosynthetic step for tryptophan-dependent pigment synthesis in Ustilago maydis. PubMed: Ruminal fermentation of propylene glycol and glycerol. PubMed: Monocarboxylate transporter 1 mediates DL-2-Hydroxy-(4-methylthio)butanoic acid transport across the apical membrane of Caco-2 cell monolayers. PubMed: Analogs of 1-phosphonooxy-2,2-dihydroxy-3-oxo-5-(methylthio)pentane, an acyclic intermediate in the methionine salvage pathway: a new preparation and characterization of activity with E1 enolase/phosphatase from Klebsiella oxytoca. PubMed: Effects of 2-hydroxy-4-(methylthio) butanoic acid (HMB) on microbial growth in continuous culture. PubMed: Analgesic doses of the enkephalin degrading enzyme inhibitor RB 120 do not have discriminative stimulus properties. PubMed: Potentiation of opioid-induced conditioned place preference by the selective serotonin reuptake inhibitor fluoxetine. PubMed: Weak tolerance to the antinociceptive effect induced by the association of a peptidase inhibitor and a CCKB receptor antagonist. PubMed: The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases. PubMed: Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins. PubMed: Purification and characterization of an enzyme involved in oxidative carbon-carbon bond cleavage reactions in the methionine salvage pathway of Klebsiella pneumoniae. PubMed: Preparations ofN, N'-ethylene-bridged dipeptides(eXX) constructed from (S)-methionine, -tryptophan, -tyrosine and-N(ɛ)-benzyloxycarbonyllysine through acid-catalyzed cyclization. PubMed: Purification and characterization of aromatic-amino-acid-glyoxylate aminotransferase from monkey and rat liver. PubMed: A possible role of cyclic AMP in mediating the effects of thyrotropin-releasing hormone on prolactin release and on prolactin and growth hormone synthesis in pituitary cells in culture. PubMed: Regulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells: elevation induced by analogs of adenosine 3':5'-cyclic monophosphate.