prothioconazole

3H-1,2,4-triazole-3-thione, 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-

CAS: 178928-70-6 C14 H15 Cl2 N3 O S MW: 344.26275000

Identification

Nameprothioconazole
IUPAC2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1H-1,2,4-triazole-3-thione
CAS Number178928-70-6
FDA UNII27B9FV58IY
Molecular FormulaC14 H15 Cl2 N3 O S
Molecular Weight344.26275000
Nikkaji NumberJ2.102.540B

Regulatory

Physical Properties

Appearance white to light beige crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 139.10 °C. @ 760.00 mm Hg (est)
Boiling Point 486.70 °C. @ 760.00 mm Hg (est)
Flash Point 479.00 °F. TCC ( 248.20 °C. ) (est)
logP (o/w) 1.770 (est)
Soluble in water, 5.531 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for prothioconazole usage levels up tonot for fragrance use.
Recommendation for prothioconazole flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2-[2-(1- chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione 2-[2-(1- chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1H-1,2,4-triazole-3-thione 2-[2-(1- chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione prothioconazole [ISO] [BSI] 3H-1,2,4- triazole-3-thione, 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro- PubMed: Distribution of prothioconazole and tebuconazole between wheat ears and flag leaves following fungicide spraying with different nozzle types at flowering. PubMed: Post-infection activities of fungicides against Cercospora arachidicola of peanut (Arachis hypogaea). PubMed: Effect of triazole pesticide formulation on bovine culture cells. PubMed: Currently used pesticides and their mixtures affect the function of sex hormone receptors and aromatase enzyme activity. PubMed: Translocation and degradation of tebuconazole and prothioconazole in wheat following fungicide treatment at flowering. PubMed: Real-time PCR to study the effect of timing and persistence of fungicide application and wheat varietal resistance on Mycosphaerella graminicola and its sterol 14α-demethylation-inhibitor-resistant genotypes. PubMed: Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-α-demethylase. PubMed: Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. PubMed: Determination of azole fungicides in atmospheric samples collected in the Canadian prairies by LC/MS/MS. PubMed: Fungicide resistance status in French populations of the wheat eyespot fungi Oculimacula acuformis and Oculimacula yallundae. PubMed: Effect of preharvest anti-fungal compounds on Aspergillus steynii and A. carbonarius under fluctuating and extreme environmental conditions. PubMed: Role of fungicides, application of nozzle types, and the resistance level of wheat varieties in the control of Fusarium head blight and deoxynivalenol. PubMed: Protective and curative efficacy of prothioconazole against isolates of Mycosphaerella graminicola differing in their in vitro sensitivity to DMI fungicides. PubMed: Impact of recently emerged sterol 14{alpha}-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity. PubMed: Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals. PubMed: Exposure reduction of seed treatments through dehusking behaviour of the wood mouse (Apodemus sylvaticus). PubMed: Temperature, moisture, and fungicide effects in managing Rhizoctonia root and crown rot of sugar beet. PubMed: Hydrogen peroxide induced by the fungicide prothioconazole triggers deoxynivalenol (DON) production by Fusarium graminearum. PubMed: Reduction of Fusarium head blight and deoxynivalenol in wheat with early fungicide applications of prothioconazole. PubMed: Meta-analysis of the effects of triazole-based fungicides on wheat yield and test weight as influenced by Fusarium head blight intensity. PubMed: Efficacy of triazole-based fungicides for fusarium head blight and deoxynivalenol control in wheat: a multivariate meta-analysis.