clofentezine
1,2,4,5-tetrazine, 3,6-bis(2-chlorophenyl)-
Identification
| Name | clofentezine |
| IUPAC | 3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine |
| CAS Number | 74115-24-5 |
| EINECS | 277-728-2 |
| FDA UNII | JS4U0R0033 |
| Molecular Formula | C14 H8 Cl2 N4 |
| Molecular Weight | 303.14976000 |
| MDL Number | MFCD00143998 |
| Nikkaji Number | J20.649K |
| Beilstein | 7137128 |
| XlogP3 | 3.20 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 182.00 °C. @ 760.00 mm Hg |
| Boiling Point | 504.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | 555.00 °F. TCC ( 290.40 °C. ) (est) |
| logP (o/w) | 3.100 |
| Soluble in | water, 1 mg/L @ 25 °C (exp) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | oral-duck LD50 > 3000 mg/kg |
| Dermal Toxicity | skin-rat LD50 > 1332 mg/kg |
| Inhalation Toxicity | inhalation-rat LC50 > 9000 mg/m3/4H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | herbicides / pesticides |
| Recommendation for clofentezine usage levels up to | not for fragrance use. |
| Recommendation for clofentezine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
acaristop
apollo 50W
bisclofentazin
bisclofentazine
3,6-bis(2-
chlorophenyl)-1,2,4,5-tetrazine
panatac
1,2,4,5-
tetrazine, 3,6-bis(2-chlorophenyl)-
PubMed:
Evaluation of etoxazole against insects and acari in vegetables in China.
PubMed:
Determination of pesticides in sunflower seeds by high-performance liquid chromatography coupled with a diode array detector.
PubMed:
High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae.
PubMed:
Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae.
PubMed:
Dispersive micro-solid phase extraction based on self-assembling, ionic liquid-coated magnetic particles for the determination of clofentezine and chlorfenapyr in environmental water samples.
PubMed:
Pesticide compatibility with natural enemies for pest management in greenhouse gerbera daisies.
PubMed:
Determination of the inheritance, cross-resistance and detoxifying enzyme levels of a laboratory-selected, spiromesifen-resistant population of the predatory mite Neoseiulus californicus (Acari: Phytoseiidae).
PubMed:
[Population-related peculiarities of molecular stress-responsive systems of bivalve mollusk under the effect of tetrazine pesticide].
PubMed:
Resistance to acaricides in Italian strains of Tetranychus urticae: toxicological and enzymatic assays.
PubMed:
Determination of clofentezine in medical herb extracts by chromatographic methods combined with diode array scanning densitometry.
PubMed:
Development, validation and application of a methodology based on solid-phase micro extraction followed by gas chromatography coupled to mass spectrometry (SPME/GC-MS) for the determination of pesticide residues in mangoes.
PubMed:
Determination of pesticides in water samples from the Wieprz-krzna Canal in the LeczyÅsko-WÅodawskie Lake District of southeastern Poland by thin-layer chromatography with diode array scanning and high-performance column liquid chromatography with diode array detection.
PubMed:
Efficacy of five selected acaricides against Tetranychus urticae (Acari: Tetranychidae) and their side effects on relevant natural enemies occurring in citrus orchards.
PubMed:
Effects of acaricides, pyrethroids and predator distributions on populations of Tetranychus urticae in apple orchards.
PubMed:
Assessment of sublethal effects of clofentezine on life-table parameters in Hawthorn spider mite (Tetranychus viennensis).
PubMed:
Baseline susceptibility and cross resistances of some new acaricides in the European red mite, Panonychus ulmi.
PubMed:
Comparative acaricide susceptibility and detoxifying enzyme activities in field-collected resistant and susceptible strains of Tetranychus urticae.
PubMed:
Toxicity of pesticides to predatory mites and insects in apple-tree site under field conditions.
PubMed:
Genetic analysis and cross-resistance spectrum of a laboratory-selected chlorfenapyr resistant strain of two-spotted spider mite (Acari: Tetranychidae).
PubMed:
Determination of fluquinconazole, pyrimethanil, and clofentezine residues in fruits by liquid chromatography with ultraviolet detection.
PubMed:
The effects of clofentezine on life-table parameters in two-spotted spider mite Tetranychus urticae.
PubMed:
An index for selective toxicity of miticides to phytophagous mites and their predators based on orchard trials.
PubMed:
Characterization of resistance to clofentezine in populations of European red mite from orchards in Ontario.
PubMed:
[Method-performance studies of notified analytical method for clofentezine].
PubMed:
Acaricide toxicity and resistance in larvae of different strains of Tetranychus urticae and Panonychus ulmi (Acari: Tetranychidae).
PubMed:
Multiresidue determination of pesticides in plants by high-performance liquid chromatography following gel permeation chromatographic clean-up.
PubMed:
Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents.
PubMed:
Determination of the pesticides diflubenzuron and clofentezine in plums, strawberries and blackcurrant-based fruit drinks by high performance liquid chromatographic/atmospheric pressure chemical ionization-mass spectrometry.
PubMed:
Relevance of kinetic and metabolic data to the interpretation of toxicological findings.