clofentezine

1,2,4,5-tetrazine, 3,6-bis(2-chlorophenyl)-

CAS: 74115-24-5 C14 H8 Cl2 N4 MW: 303.14976000

Identification

Nameclofentezine
IUPAC3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine
CAS Number74115-24-5
EINECS277-728-2
FDA UNIIJS4U0R0033
Molecular FormulaC14 H8 Cl2 N4
Molecular Weight303.14976000
MDL NumberMFCD00143998
Nikkaji NumberJ20.649K
Beilstein7137128
XlogP33.20 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 182.00 °C. @ 760.00 mm Hg
Boiling Point 504.40 °C. @ 760.00 mm Hg (est)
Flash Point 555.00 °F. TCC ( 290.40 °C. ) (est)
logP (o/w) 3.100
Soluble in water, 1 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-duck LD50 > 3000 mg/kg
Dermal Toxicityskin-rat LD50 > 1332 mg/kg
Inhalation Toxicityinhalation-rat LC50 > 9000 mg/m3/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for clofentezine usage levels up tonot for fragrance use.
Recommendation for clofentezine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

acaristop apollo 50W bisclofentazin bisclofentazine 3,6-bis(2- chlorophenyl)-1,2,4,5-tetrazine panatac 1,2,4,5- tetrazine, 3,6-bis(2-chlorophenyl)- PubMed: Evaluation of etoxazole against insects and acari in vegetables in China. PubMed: Determination of pesticides in sunflower seeds by high-performance liquid chromatography coupled with a diode array detector. PubMed: High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae. PubMed: Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae. PubMed: Dispersive micro-solid phase extraction based on self-assembling, ionic liquid-coated magnetic particles for the determination of clofentezine and chlorfenapyr in environmental water samples. PubMed: Pesticide compatibility with natural enemies for pest management in greenhouse gerbera daisies. PubMed: Determination of the inheritance, cross-resistance and detoxifying enzyme levels of a laboratory-selected, spiromesifen-resistant population of the predatory mite Neoseiulus californicus (Acari: Phytoseiidae). PubMed: [Population-related peculiarities of molecular stress-responsive systems of bivalve mollusk under the effect of tetrazine pesticide]. PubMed: Resistance to acaricides in Italian strains of Tetranychus urticae: toxicological and enzymatic assays. PubMed: Determination of clofentezine in medical herb extracts by chromatographic methods combined with diode array scanning densitometry. PubMed: Development, validation and application of a methodology based on solid-phase micro extraction followed by gas chromatography coupled to mass spectrometry (SPME/GC-MS) for the determination of pesticide residues in mangoes. PubMed: Determination of pesticides in water samples from the Wieprz-krzna Canal in the Leczyńsko-Włodawskie Lake District of southeastern Poland by thin-layer chromatography with diode array scanning and high-performance column liquid chromatography with diode array detection. PubMed: Efficacy of five selected acaricides against Tetranychus urticae (Acari: Tetranychidae) and their side effects on relevant natural enemies occurring in citrus orchards. PubMed: Effects of acaricides, pyrethroids and predator distributions on populations of Tetranychus urticae in apple orchards. PubMed: Assessment of sublethal effects of clofentezine on life-table parameters in Hawthorn spider mite (Tetranychus viennensis). PubMed: Baseline susceptibility and cross resistances of some new acaricides in the European red mite, Panonychus ulmi. PubMed: Comparative acaricide susceptibility and detoxifying enzyme activities in field-collected resistant and susceptible strains of Tetranychus urticae. PubMed: Toxicity of pesticides to predatory mites and insects in apple-tree site under field conditions. PubMed: Genetic analysis and cross-resistance spectrum of a laboratory-selected chlorfenapyr resistant strain of two-spotted spider mite (Acari: Tetranychidae). PubMed: Determination of fluquinconazole, pyrimethanil, and clofentezine residues in fruits by liquid chromatography with ultraviolet detection. PubMed: The effects of clofentezine on life-table parameters in two-spotted spider mite Tetranychus urticae. PubMed: An index for selective toxicity of miticides to phytophagous mites and their predators based on orchard trials. PubMed: Characterization of resistance to clofentezine in populations of European red mite from orchards in Ontario. PubMed: [Method-performance studies of notified analytical method for clofentezine]. PubMed: Acaricide toxicity and resistance in larvae of different strains of Tetranychus urticae and Panonychus ulmi (Acari: Tetranychidae). PubMed: Multiresidue determination of pesticides in plants by high-performance liquid chromatography following gel permeation chromatographic clean-up. PubMed: Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. PubMed: Determination of the pesticides diflubenzuron and clofentezine in plums, strawberries and blackcurrant-based fruit drinks by high performance liquid chromatographic/atmospheric pressure chemical ionization-mass spectrometry. PubMed: Relevance of kinetic and metabolic data to the interpretation of toxicological findings.