tubocurarine chloride anhydrous
tubocurarine, chloride, hydrochloride, (+)- (8CI)
Identification
| Name | tubocurarine chloride anhydrous |
| CAS Number | 57-94-3 |
| EINECS | 200-356-9 |
| FDA UNII | 7BCM17J5YA |
| Molecular Formula | C37 H42 Cl2 N2 O6 |
| Molecular Weight | 681.65494000 |
| MDL Number | MFCD00013471 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| Soluble in | water, 0.2304 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intravenous-guinea pig LD50 66 ug/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 640 ug/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for tubocurarine chloride anhydrous usage levels up to | not for fragrance use. |
| Recommendation for tubocurarine chloride anhydrous flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
2,2',2'-
trimethyl-6,6'-bis(methyloxy)tubocuraran-2,2'-diium-7',12'-diol dichloride
tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-, chloride, hydrochloride
tubocurarine, chloride, hydrochloride, (+)- (8CI)
PubMed:
Nicotine promotes cell proliferation and induces resistance to cisplatin by α7 nicotinic acetylcholine receptorâmediated activation in Raw264.7 and El4 cells.
PubMed:
Plasmodium falciparum: growth response to potassium channel blocking compounds.
PubMed:
The effect of some curarizing drugs in unanaesthetized man. I. d-Tubocurarine chloride, gallamonium iodide, decamethonium iodide, succinylcholine iodide and its bis-monoethyl-substituted derivative in single or repeated doses. Acta Anaesth. Scandinav. 1957, 1, 15-39.
PubMed:
Nicotine modulation of apoptosis in human coronary artery endothelial cells.
PubMed:
Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4 Deg C in Polypropylene Syringes.
PubMed:
N-cholinergic facilitation of glutamate release from an individual retinotectal fiber in frog.
PubMed:
Nicotine inhibition of apoptosis in murine immune cells.
PubMed:
Effect of forskolin on acetylcholine-induced current in rat pheochromocytoma cells.
PubMed:
Influence of muscarinic ligands on the amplitudes of the evoked surface potential's late components in the optic tectum of the urodele Plethodon jordani.
PubMed:
Effects of conditioning stimulation of the central amygdaloid nucleus on tooth pulp-driven neurons in the cat somatosensory cortex (SI).
PubMed:
Activation of nicotinic receptor-induced postsynaptic responses to luteinizing hormone-releasing hormone in bullfrog sympathetic ganglia via a Na+-dependent mechanism.
PubMed:
Characterization and evaluation of d-(+)-tubocurarine chloride as a chiral selector for capillary electrophoretic enantioseparations.
PubMed:
Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats.
PubMed:
Comparison of nicotinic receptor binding and biotransformation of coniine in the rat and chick.
PubMed:
Activity-dependent induction of functional secretory properties at cultured neuromuscular synapses of Helisoma.
PubMed:
5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization.
PubMed:
Thermogenesis induced by inhibition of shivering during cold exposure in exercise-trained rats.
PubMed:
Criteria for use of pancuronium bromide, vecuronium bromide, atracurium besylate, tubocurarine chloride, metocurine iodide, pipecuronium bromide, and doxacurium chloride in adults.
PubMed:
Characterization of cholinergic regulation of seizures by the midline thalamus.
PubMed:
Effects of morphine, H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and B-HT920 on non-cholinergic nerve-mediated bronchoconstriction in pithed guinea-pigs.
PubMed:
Comparison of enflurane and halothane in hypotensive eye surgery.
PubMed:
Measurement of D-tubocurarine chloride in human urine using solid-phase extraction and reversed-phase high-performance liquid chromatography with ultraviolet detection.
PubMed:
Effects of partial neuromuscular blockade on sympathetic nerve responses to static exercise in humans.
PubMed:
[Effects of nicotine on automaticity of sinoatrial node in rabbit heart].
PubMed:
Examination of the role of calcium in the adrenaline-induced hyperpolarization of bullfrog sympathetic neurons.
PubMed:
An acetylcholine-induced potassium current in tail sensory neurons in the pleural ganglion of Aplysia.
PubMed:
Tubocurarine chloride inhibits rod outer segment shedding in the frog retina.
PubMed:
Concentration-dependent interaction of theophylline with d-tubocurarine.
PubMed:
Dimethyl-1-curine dimethochloride--an alternative for d-tubocurarine chloride.
PubMed:
The pathway for the slow inhibitory postsynaptic potential in bullfrog sympathetic ganglia.
PubMed:
Ileal and colonic propulsive behavior: contribution of enteric neural circuits.
PubMed:
Effects of locally and systemically administered cholinoceptor antagonists on the secretory response of human eccrine sweat glands to carbachol.
PubMed:
Determination of D-tubocurarine chloride or metocurine iodide in human plasma by high-performance liquid chromatography with ultraviolet detection.
PubMed:
Neuronotrophic effects of skeletal muscle fractions on neurite development.
PubMed:
Peripheral neural input to neurons of the middle cervical ganglion in the cat.
PubMed:
Synaptic activation of phasic bursting in rat supraoptic nucleus neurones recorded in hypothalamic slices.
PubMed:
Electrophysiology of neurones of the inferior mesenteric ganglion of the cat.
PubMed:
Progression of age changes in synaptic transmission at mouse neuromuscular junctions.
PubMed:
[Non-quantum secretion of acetylcholine in a nerve-muscle preparation of the diaphragm in dystrophic mice of line 129/Rej].
PubMed:
Effect of substance P sequences on isolated neurons of Lymnaea stagnalis.
PubMed:
In the eye (D-Pro2, D-Trp7,9)-SP is a substance P agonist, which modifies the responses to substance P, prostaglandin E1 and antidromic trigeminal nerve stimulation.
PubMed:
Motor dysfunction in thymoma rats: comparison between fast and slow muscles.
PubMed:
[Nonquantum release of acetylcholine in frog neuromuscular junction after blocking of axoplasmic transport with colchicine].
PubMed:
The ionization of morphine, hydroxyamphetamine and (+)-tubocurarine chloride and a new method for calculating zwitterion constants.
PubMed:
The effect of neuromuscular blocking agents on the acetylcholine receptors of different skeletal muscles.
PubMed:
Modification by strychnine and D-tubocurarine of cardiac vagal inhibition in dogs.
PubMed:
[Effect of curare-like substances on the coronary circulation and myocardial oxygen demand].
PubMed:
Inotropic effects of non-depolarizing muscle relaxants in isolated canine heart muscle.
PubMed:
Selective proliferation and accumulation of chondroprogenitor cells as the mode of action of biomechanical factors during secondary chondrogenesis.
PubMed:
Continuous muscle fiber activity: a case with unusual clinical features.
PubMed:
[Effects of acetylcholine and succinylcholine on isolated frog neuromuscular spindle].
PubMed:
Preparation of semisynthetic (+)-tubocurarine chloride.
PubMed:
Pharmacokinetics and pharmacological effects of neostigmine in man.
PubMed:
Dequaternization of curare bases with sodium thiophenoxide and ethanolamine.
PubMed:
Conditioning under carbolonium bromide and D--tubocurarine chloride paralysis.
PubMed:
Hofmann elimination with diazomethane on curare bases and selected quaternary tetrahydroisoquinoline alkaloids.
PubMed:
Binding of iodine 125 alpha-bungarotoxin to the thymus of mice.
PubMed:
Effect of acetylcholine and d-tubocurarine chloride on neuromuscular transmission in Acheta domesticus and Tenebrio molitor.
PubMed:
The effect of the CO2/HCO3- buffer system on the membrane potential of frog skeletal muscle.
PubMed:
Quantitative analysis of d-tubocurarine chloride in curare by column liquid chromatography.
PubMed:
Audiogenic seizures in curarized mice.
PubMed:
Studies of nicotinic acetylcholine receptor protein from rat brain. II. Partial purification.
PubMed:
[Neuromuscular blocking properties of tobramycin, dibekacin and ribostamycin in man (author's transl)].
PubMed:
[The influence of stimulation of the glossopharyngeal nerve on the gastric inhibitory and excitatory motor reflexes (author's transl)].
PubMed:
Effect of glucagon on hepatic circulation in the pig.
PubMed:
Studies of nicotinic acetylcholine receptor protein from rat brain.
PubMed:
The effects of d-tubocurarine chloride and respiratory settings on heart rate and blood gas composition in the albino rat.
PubMed:
Mechanism of colistin-induced neuromuscular depression.
PubMed:
Neuromuscular blocking drugs and heart rate changes after direct nerve stimulation and during classical conditioning in cats.
PubMed:
[Effects of d-tubocurarine chloride on myocardial contractility].
PubMed:
[Effect of stearic acid on the degree of tubocurarine chloride extraction from aqueous solutions by organic solvents as dependent on the pH of the medium].
PubMed:
Effects of hayatin methochloride & (+)-tubocurarine chloride on autonomic ganglia of cats.
PubMed:
Club-foot and intra-uterine growth retardation produced by tubocurarine chloride in the rat fetus.
PubMed:
[Influence of muscle relaxing agents, pancuronium bromide, d-tubocurarine chloride, on human adrenocotrical function].
PubMed:
[Effect of ether and fluorothane on the comparative sensitivity of muscles to anatruxonium and D-tubocurarine chloride].
PubMed:
[Mechanism of neuromuscular transmission in insects. Effects of tubocurarine chloride and flaxedil (gallamine)].
PubMed:
The relation between quantum content and facilitation at the neuromuscular junction of the frog.
PubMed:
[Anesthesia with combined nitrous oxide, oxygen and tubocurarine chloride for children (Jackson Rees's method). 1].
PubMed:
The effect of atropine on the frog sartorius neuromuscular junction.
PubMed:
Response to tubocurarine chloride and its reversal by neostigmine methylsulfate in man.
PubMed:
d-Tubocurarine chloride by T. Cecil Gray.
PubMed:
The influence of carbon dioxide on the neuromuscular blocking properties of tubocurarine chloride and diallyl-nor-toxiferine dichloride (Alloferin Roche) in man. A comparative study.
PubMed:
[Comparative sensitivity of neuro-muscular synapses of different muscles toward d-tubocurarine chloride and alpha-truxillic acid].
PubMed:
The action of tubocurarine and atropine on the normal and denervated rat diaphragm.
PubMed:
The effect of (+)-tubocurarine chloride and of acute hypotension on electrocortical activity of the cat.
PubMed:
d-tubocurarine chloride: effect on insects.
PubMed:
[New methods in the chemical determination of (+)-tubocurarine chloride].
PubMed:
[The effect of D-tubocurarine chloride on the metabolism of chick embryos].
PubMed:
THE INFLUENCE OF CARBON DIOXIDE ON THE NEUROMUSCULAR BLOCK CAUSED BY TUBOCURARINE CHLORIDE IN THE HUMAN SUBJECT.
PubMed:
A micro spectrophotometric method for the analysis of minute concentrations of d-tubocurarine chloride in plasma.
PubMed:
Action of d-tubocurarine chloride on net flux of water across isolated frog skin.
PubMed:
[Experimental research on variations in blood coagulation induced by treatment with d-tubocurarine chloride in the rabbit].
PubMed:
[Mechanism of action of d-tubocurarine chloride in the treatment of tetanus. Results of laboratory investigations].
PubMed:
[The effect of d-tubocurarine chloride on arterial pressure in general anesthesia].
PubMed:
Induced tolerance to D-tubocurarine chloride in the cat.
PubMed:
Increase by chlorothiazide of the paralysing activity of d-tubocurarine chloride.
PubMed:
Severe tetanus treated with d-tubocurarine chloride tubarine and tank respiration.
PubMed:
Prolonged apnoea due to d-tubocurarine chloride.
PubMed:
The binding of d-tubocurarine chloride to plasma proteins.
PubMed:
The effect of d-tubocurarine chloride on the blood-pressure of anaesthetised patients.
PubMed:
[Intubation anesthesia with curare; a review of 2000 cases of anesthesia with d-tubocurarine chloride].
PubMed:
The role of the canine liver in the detoxication of d-tubocurarine chloride, gallamine triethiodide and laudexium.
PubMed:
A new ultraviolet spectrophotometric method for the determination of d-tubocurarine chloride in plasma.
PubMed:
Treatment of severe tetanus with d-tubocurarine chloride and intermittent positive-pressure respiration.
PubMed:
[Effect of delta-tubocurarine chloride on oxygen consumption of the eggs of Psammechinus microtuberculatus].
PubMed:
Treatment of tetanus with d-tubocurarine chloride.
PubMed:
Respiratory arrest following intramuscular injection of tubocurarine chloride; report of a case.
PubMed:
The relationship of the dosage of d-tubocurarine chloride and laudolissin to body weight, sex and age.
PubMed:
Black widow spider (Latrodectus mactans) poisoning treated with d-tubocurarine chloride.
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Resistance to d-tubocurarine chloride in the presence of liver damage.
PubMed:
Use of slowly absorbed suspension of d-tubocurarine chloride in rectal surgery.
PubMed:
Placental transmission of d-tubocurarine chloride from maternal to fetal circulation in dogs.
PubMed:
Slowly absorbed tubocurarine chloride in orthopedics.
PubMed:
[Chemical determination of the blood picture and urinary excretion of d-tubocurarine chloride].
PubMed:
Studies on the pharmacodynamics of curare in the horse. I. Dosage and physiological activity of d-tubocurarine chloride.
PubMed:
Influence of controlled respiration on dosage of thiopentone and D-tubocurarine chloride required for abdominal surgery.
PubMed:
Comparative potency of d-tubocurarine chloride U.S.P. and dimethyl ether d-tubocurarine iodide.
PubMed:
The distribution, metabolism, and excretion of d-tubocurarine chloride and related compounds in man and other animals.
PubMed:
[Comparative study of iodide of decamethonium and D-tubocurarine chloride].
PubMed:
D-tubocurarine chloride in strabismus operations in children; a minimal dosage technique.
PubMed:
D-tubocurarine chloride concentrations in human plasma after intravenous injection during anesthesia.
PubMed:
An investigation of the synergisms between d-tubocurarine chloride and thiopentone.
PubMed:
Use of gallamine triethiodide (flaxedil) in modifying E.C.T.; a comparison with D-tubocurarine chloride and decamethonium iodide.
PubMed:
The use of d-tubocurarine chloride for cesarean section; a report of 210 cases.
PubMed:
[Action of d-tubocurarine chloride on isolated frog heart].
PubMed:
The action of d-tubocurarine chloride on the small intestine of rabbits.
PubMed:
Muscular relaxants; a comparison of decamethonium iodide and d-tubocurarine chloride in anaesthesia.
PubMed:
Effect of D-tubocurarine chloride and carbaminoylcholine on the respiration of Daphnia.
PubMed:
A comparison of the action of decamethonium iodide C10 & d-tubocurarine chloride in anaesthesia.
PubMed:
d-Tubocurarine chloride and enzyme activity.
PubMed:
Use of slowly absorbed suspension of d-tubocurarine chloride in traumatic injury.
PubMed:
A method for quantitative estimation of small amounts of D-tubocurarine chloride in plasma.
PubMed:
[D-tubocurarine chloride and acetylcholine-pilocarpine antagonism; research carried out in surviving ileum of guinea pig].
PubMed:
[Convulsive action of d-tubocurarine made to act directly on nerve tissue. I. Effect of introduction of d-tubocurarine chloride into the cisterna magna of the rabbit].
PubMed:
Treatment of two cases of tetanus with d-tubocurarine chloride in peanut oil with myricin.
PubMed:
Evipal sodium-d-tubocurarine chloride for endotracheal intubation; preliminary study.
PubMed:
The action of d-tubocurarine chloride and other curarizing drugs on the growth of certain microorganisms.
PubMed:
Action of d-tubocurarine chloride on the central nervous system of the cat.
PubMed:
The relative susceptibility of the diaphragm, as compared with the limb muscles, to the effects of tubocurarine chloride.
PubMed:
The assay of d-tubocurarine chloride on the isolated rat-diaphragm; a statistical examination.
PubMed:
The action of d-tubocurarine chloride on foetal neuromuscular transmission and the placental transfer of this drug in the rabbit.
PubMed:
Anaesthesia in caesarean section with special reference to the use of d-tubocurarine chloride.
PubMed:
An account of, and conclusions drawn from, 50 cases of anaesthesia with d-tubocurarine chloride adjuvant.
PubMed:
The estimation of d-tubocurarine chloride.
PubMed:
Dextro-tubocurarine chloride: A provisional British standard.
PubMed:
A system of anaesthesia using d-tubocurarine chloride for chest surgery.
PubMed:
A system of anaesthesia using d-tubocurarine chloride for chest surgery.
PubMed:
d-Tubocurarine chloride.
PubMed:
Pharmacological activities in different rodent species of d-tubocurarine chloride and the dimethyl ether of d-tubocurarine iodide.
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Idiosyncrasy to d-tubocurarine chloride.
PubMed:
Idiosyncrasy to d-tubocurarine chloride.
PubMed:
Curare alkaloids; constitution of dextro-tubocurarine chloride.
PubMed:
Unjustified use of d-tubocurarine chloride.
PubMed:
Unjustified use of d-tubocurarine chloride.
PubMed:
Unjustified use of d-tubocurarine chloride.
PubMed:
Unjustified use of d-tubocurarine chloride.
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Delta-tubocurarine chloride as an adjuvant in anaesthesia.
PubMed:
The use of d-tubocurarine chloride in anaesthesia.
PubMed:
The Use of D-Tubocurarine Chloride in Anaesthesia: Lecture delivered at The Royal College of Surgeons of England on 17th April, 1947.
PubMed:
d-Tubocurarine chloride in electro-convulsion therapy.
PubMed:
Use of d-tubocurarine chloride and thiopentone in electroconvulsion therapy.
PubMed:
The effect of d-tubocurarine chloride on sensation in man.
PubMed:
Curare; pharmacology and clinical applications of d-tubocurarine chloride.
PubMed:
Technique for the use of d-tubocurarine chloride with balanced anaesthesia.
PubMed:
Tubocurarine chloride as an adjunct to anaesthesia; report on 180 cases.
PubMed:
A milestone in anaesthesia? (d-tubocurarine chloride).
PubMed:
A Milestone in Anæsthesia?: (d-Tubocurarine Chloride).
PubMed:
A Milestone in Anaesthesia?: (d-Tubocurarine Chloride).
PubMed:
Tubocurarine chloride in anaesthesia.
PubMed:
d-TUBOCURARINE CHLORIDE AND CHOLINE ESTERASE.