k-strophanthoside
strophanthidin + cymarose + beta-glucose + alpha-glucose
Identification
| Name | k-strophanthoside |
| IUPAC | (3S,5S,8R,9S,10S,13R,14S)-5,14-dihydroxy-3-[(2R,4S,5R,6R)-4-methoxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydro |
| CAS Number | 33279-57-1 |
| EINECS | 251-439-1 |
| FDA UNII | 8141H9654J |
| Molecular Formula | C42 H64 O19 |
| Molecular Weight | 872.95688000 |
| MDL Number | MFCD00167450 |
| XlogP3 | -2.90 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 1027.20 °C. @ 760.00 mm Hg (est) |
| Flash Point | 579.00 °F. TCC ( 304.00 °C. ) (est) |
| logP (o/w) | -1.600 (est) |
| Soluble in | water, 3.391e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intravenous-cat LD50 130 ug/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for k-strophanthoside usage levels up to | not for fragrance use. |
| Recommendation for k-strophanthoside flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
strophanthidin + cymarose + beta-glucose + alpha-glucose
k-
strophanthidin-gamma
strophanthoside-K
k-
strophantosid
k-
strophantoside
PubMed:
LC-ESI-MS/MS characterization of strophanthin-K.
PubMed:
Interactions of cationic drugs and cardiac glycosides at the hepatic uptake level: studies in the rat in vivo, isolated perfused rat liver, isolated rat hepatocytes and oocytes expressing oatp2.
PubMed:
Cardenolides as oviposition deterrents to twoPieris species: Structure-activity relationships.
PubMed:
Biodistribution of two 99mTc-cardiac glycosides with end glucose unit: effect of lipophilicity on their relative myocardial accumulation.
PubMed:
The action of prostaglandins on ureter smooth muscle of guinea-pig.
PubMed:
Changes in autorhythmic heart frequency elicited by redox agents.
PubMed:
Experimental investigation of the effect of cardiac glycosides on the ischemic coronary circulation.
PubMed:
Absorption, metabolism and elimination of strophanthus glycosides in man.
PubMed:
Activatory effect of two cardioglycosides on Cavia cobaya kidney Na+/K+-ATPase activity.
PubMed:
Energy transport at the toxic damaged heart muscle cells.
PubMed:
Effect of cardiac glycosides on the coronaries: physiologic and morphologic studies in the dog heart.
PubMed:
Impact of neonatal treatment with cardioactive glycosides (digoxin, ouabain) on receptor binding capacity, blood level and cardiac function in the adult rat. Extension of the imprinting theory.
PubMed:
Relationship between the tissue redox state potential and dak/dt changes of [K+]0 activity during k-strophantoside or acetylcholine induced contractures.
PubMed:
[Effects of glucosides on a spontaneously active vascular smooth muscle in vitro (author's transl)].
PubMed:
Nifedipine for digitalis-induced arrhythmias.
PubMed:
Cardiomechanical effect of k-strophanthoside administered to healthy volunteers by the rectal route.
PubMed:
Choleresis and hepatic transport mechanisms. III. Binding of ouabain and K-strophanthoside to biliary micelles and influence of choleresis on their biliary excretion.
PubMed:
Bilary and urinary excretion of five cardiac glycosides and its correlation with their physical and chemical properties.
PubMed:
Positive inotropic action of Solanaceae glycoalkaloids.
PubMed:
Plasma turnover and excretion of K-strophanthoside-3H in human volunteers after parenteral administration.
PubMed:
[Plasma levels and urinary elimination of k-strophanthoside in intravenous administration in patients with renal insufficiency].
PubMed:
[Plasma levels and urinary elimination of k-strophanthoside in venous and muscular administration in cardiac disease patients].
PubMed:
Subcellular distribution of K-strophanthoside (3H) in isolated guinea-pig hearts.
PubMed:
The absorption, distribution and excretion of K-strophanthoside-3H in guinea pigs after parenteral administration.
PubMed:
[Plasma concentration and biliary and urinary excretion of K-strophanthoside in subjects with biliary fistula (author's transl)].
PubMed:
Plasma levels and urinary excretion of K-strophanthoside (3H) administered rectally to human subjects.
PubMed:
Absorption, distribution and excretion of K-strophanthoside(3H) administered rectally to guinea-pigs.
PubMed:
[Subcellular distribution of K-strophanthoside in the isolated guinea-pig heart].
PubMed:
[Biliary and urinary elimination and intrahepatic circulation of K-strophanthoside-(H3) in humans and guinea pigs].
PubMed:
[Plasmatic levels and urinary elimination of K-strophanthoside after intravenous administration in normal humans].
PubMed:
[Absorption of K strophanthoside-H 3 through the rectal mucosa of the guinea pig].
PubMed:
[Metoclopramide and electrocardiographic changes caused by KC1, BaC12, CaC12, MgC12, aconitine, k-strophanthoside, vasopressin and by asphyxia].
PubMed:
Adenosine triphosphatase activity in the membranes of the squid nerve fiber.
PubMed:
Nature of the Schwann cell electrical potential. Effects of the external ionic concentrations and a cardiac glycoside.
PubMed:
5-Hydroxytryptamine and the toxicity of k-strophanthoside.
PubMed:
[Therapeutic and hemodynamic effects of a lyophilized preparation with a base of K-strophanthoside].
PubMed:
[Action of k-strophanthoside on erythrocyte-plasma exchange of the potassium ion in human heparinized blood: study in vitro and in vivo].
PubMed:
[Behavior of various enzymes from rat myocardium during acute K-strophanthoside poisoning].
PubMed:
Depolarizing action of K-strophantine and K-strophanthoside on isolated frog skin.
PubMed:
[Effects of k-strophanthoside and adrenal cortical steroids on sodium transport through isolated frog skin].
PubMed:
[Behavior of several enzymatic activities of the rabbit heart treated with cardiac glycosides. I. Variations in the succinic dehydrogenase and cytochrome oxidase activity of the rabbit heart after a single dose and after prolonged administration of K-strophanthoside].
PubMed:
Unipolar electrocardiograms of isolated rabbit's hearts treated with k-strophanthoside (strophoside).
PubMed:
[Allergy to k-strophanthoside and other cardiokinetic glucosides; considerations on the dangers of intolerance of allergic types to drugs in general].
PubMed:
Influence of nitrate ion upon the synergistic effects of glucose and k-strophanthoside.
PubMed:
Dibucaine hydrochloride in the control of K-strophanthoside-induced ventricular tachycardia and other toxic manifestations.
PubMed:
Treatment of cardiac emergencies with K-strophanthoside and lanatoside C.
PubMed:
Influence of striated muscle activity on the lethal dose of k-strophanthoside.