sennoside B
5,5'-bis(b-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-[9,9'-Bianthracene]-2,2'-dicarboxylic acid
Identification
| Name | sennoside B |
| CAS Number | 128-57-4 |
| EINECS | 204-895-0 |
| FDA UNII | F887D1637W |
| Molecular Formula | C42 H38 O20 |
| Molecular Weight | 862.74886000 |
| MDL Number | MFCD00151528 |
| Nikkaji Number | J238.581C |
| Beilstein | 5723747 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 1144.80 °C. @ 760.00 mm Hg (est) |
| Flash Point | 659.00 °F. TCC ( 348.60 °C. ) (est) |
| logP (o/w) | 1.880 (est) |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for sennoside B usage levels up to | not for fragrance use. |
| Recommendation for sennoside B flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
5,5'-bis(b-D-
glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-[9,9'-Bianthracene]-2,2'-dicarboxylic acid
PubMed:
Experimental evaluation of radioiodinated sennoside B as a necrosis-avid tracer agent.
PubMed:
Monitoring of 29 weight loss compounds in foods and dietary supplements by LC-MS/MS.
PubMed:
[Analysis on changes of purgative biopotency in different processed products of rhubarb].
PubMed:
Inhibition of antigen trafficking through scavenger receptor A.
PubMed:
[Determination of sennoside A and sennoside B simultaneously in health food by HPLC].
PubMed:
Simple and rapid analysis of sennoside A and sennoside B contained in crude drugs and crude drug products by solid-phase extraction and high-performance liquid chromatography.
PubMed:
Simultaneous analysis of nine components in patch preparations of Ru-Yi-Jin-Huang-San by high-performance liquid chromatography.
PubMed:
Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells.
PubMed:
Development of eastern blotting technique for sennoside A and sennoside B using anti-sennoside A and anti-sennoside B monoclonal antibodies.
PubMed:
Enzyme-linked immunosorbent assay for total sennosides using anti-sennside A and anti-sennoside B monoclonal antibodies.
PubMed:
Simultaneous determination of anthraquinones in rhubarb by high-performance liquid chromatography and capillary electrophoresis.
PubMed:
Liquid chromatographic determination of sennosides in Cassia angustifolia leaves.
PubMed:
Insulin sensitizing and alpha-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma.
PubMed:
Simultaneous determination of anthraquinones, their 8-beta-D-glucosides, and sennosides of Rhei Rhizoma by capillary electrophoresis.
PubMed:
Development of a one-step immunochromatographic strip test for the detection of sennosides A and B.
PubMed:
Pharmacokinetics of rhein from Onpi-to, an Oriental herbal medicine, in rats.
PubMed:
Production of monoclonal antibodies against a major purgative component, sennoside B, their characterization and use in ELISA.
PubMed:
[The effects of kampo-formulation and the constituting crude drugs, prescribed for the treatment of peptic ulcer on H,K-ATPase activity].
PubMed:
A blinded, randomized comparison of a novel, low-dose, triple regimen with fleet phospho-soda: a study of colon cleanliness, speed and success of colonoscopy.
PubMed:
[Determination of sennoside A and sennoside B in formulation using capillary electrophoresis].
PubMed:
Genotoxicity of sennosides on the bone marrow cells of mice.
PubMed:
Purification and characterization of a novel sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN, a human intestinal anaerobe.
PubMed:
A sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN is inducible.
PubMed:
[Sennosides Reference Standard (Control 951) of the National Institute of Health Sciences].
PubMed:
A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone.
PubMed:
Determination of eight constituents of hsiao-cheng-chi-tang by high-performance liquid chromatography.
PubMed:
Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins.
PubMed:
The senna drug and its chemistry.
PubMed:
Cleavages of the O- and C-glucosyl bonds of anthrone and 10,10'-bianthrone derivatives by human intestinal bacteria.
PubMed:
New aspects on the metabolism of the sennosides.
PubMed:
Stimulation of PGE2 synthesis and water and electrolyte secretion by senna anthraquinones is inhibited by indomethacin.
PubMed:
Formation and distribution of sennosides in Cassia angustifolia, as determined by a sensitive and specific radioimmunoassay.
PubMed:
[Transport and mode of action of sennosides].
PubMed:
[Quantitative chromatographic determination of the active principles of senna (sennoside A, sennoside B)].