sennidin A
dihydroxydianthrone
Identification
| Name | sennidin A |
| IUPAC | (9R)-9-[(9R)-2-carboxy-4,5-dihydroxy-10-oxo-9H-anthracen-9-yl]-4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylic acid |
| CAS Number | 641-12-3 |
| EINECS | 211-371-5 |
| FDA UNII | O8793FIM31 |
| Molecular Formula | C30 H18 O10 |
| Molecular Weight | 538.46546000 |
| MDL Number | MFCD00017368 |
| Nikkaji Number | J562.021J |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 801.80 °C. @ 760.00 mm Hg (est) |
| Flash Point | 847.00 °F. TCC ( 452.60 °C. ) (est) |
| logP (o/w) | 8.240 (est) |
| Soluble in | water, 0.0007279 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for sennidin A usage levels up to | not for fragrance use. |
| Recommendation for sennidin A flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(9,9'-
bianthracene)-2,2'-dicarboxylic acid, 9,9',10,10'-tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo-, (R*,R*)-(+)-
(9R)-9-[(9R)-2-
carboxy-4,5-dihydroxy-10-oxo-9H-anthracen-9-yl]-4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylic acid
dihydroxydianthrone
(R*,R*)-(+)-9,9',10,10'-
tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo(9,9'-bianthracene)-2,2'-dicarboxylic acid
PubMed:
Necrosis targeted combinational theragnostic approach using radioiodinated Sennidin A in rodent tumor models.
PubMed:
Sennidin stimulates glucose incorporation in rat adipocytes.
PubMed:
The influence of the sennosides on absorption of glycyrrhetic acid in rats.
PubMed:
A sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN is inducible.
PubMed:
Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins.
PubMed:
The senna drug and its chemistry.