isophorone

3,5,5-trimethylcyclohex-2-en-1-one

CAS: 78-59-1 C9 H14 O MW: 138.20978000 woody green

Identification

Nameisophorone
IUPAC3,5,5-trimethylcyclohex-2-en-1-one
CAS Number78-59-1
EINECS201-126-0
FDA UNII2BR99VR6WA
Molecular FormulaC9 H14 O
Molecular Weight138.20978000
MDL NumberMFCD00001584
Nikkaji NumberJ1.954B
Beilstein1280721
CoE Number11918

Regulatory

JECFA Food Flavoring1112 isophorone
DG SANTE Food Flavourings07.126 3,5,5-trimethylcyclohex-2-en-1-one
FEMA Number3553
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)78-59-1 ; ISOPHORONE
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 97.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.91900 to 0.92700 @ 25.00 °C.
Pounds per Gallon - (est). 7.647 to 7.714
Refractive Index 1.47400 to 1.48100 @ 20.00 °C.
Melting Point -8.00 °C. @ 760.00 mm Hg
Boiling Point 213.00 to 215.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.150000 mmHg @ 25.00 °C. (est)
Vapor Density 4.7 ( Air = 1 )
Flash Point 184.00 °F. TCC ( 84.44 °C. )
logP (o/w) 1.700
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesnot used anymore

Organoleptic Properties

Odor Description
at 0.10 % in propylene glycol.
Cooling, woody, sweet, green, camphoreous, fruity and musty
Taste Description at 30.00 ppm.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 1870 mg/kg
Dermal Toxicityskin-rabbit LD50 1500 ul/kg
Inhalation Toxicityinhalation-rat LC50 7000 mg/m3

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryadhesives for food packaging
IFRA Critical EffectInsufficient data
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%)Category 1: Products applied to the lips
NotesIFRA FLAVOR REQUIREMENTS:
Maximised Survey-derived Daily Intakes (MSDI-EU)4.60 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)0.10 (μg/capita/day)
Structure ClassII
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

FL citrus FR fruit FL grapefruit FL mint FL orange FL papaya

Natural Occurrence

artemisia diffusa krasch. ex poljak oil iran @ 0.80% Data cabbage cranberry fruit cymbopogon citratus (dc.) stapf. oil cuba @ <0.10% Data filbert roasted filbert grapefruit juice kohlrabi stem labdanum oil @ 0.35% Data macadamia nut mushroom PMC mustard white mustard osmanthus papaya fruit patchouli oil china @ 0.03% Data pea plum fruit plumcot fruit PMC saffron stigma tobacco burley tobacco wine

Synonyms

iso acetophorone cyclohex-2-en-1-one, 3,5,5-trimethyl- 2- cyclohexen-1-one, 3,5, 5-trimethyl- 2- cyclohexen-1-one, 3,5,5-trimethyl- iso foron iso octopherone a-iso phoron iso phorone 3,5,5- trimethyl cyclohex-2-en-1-one 3,5,5- trimethyl cyclohex-2-enone 3,3,5- trimethyl cyclohex-5-en-1-one 1,5,5- trimethyl-1-cyclohexen-3-one 3,5,5- trimethyl-2-cyclohexen-1-one 3,3,5- trimethyl-2-cyclohexene-1-one 3,5,5- trimethyl-2-cyclohexenone 1,1,3- trimethyl-3-cyclohexene-5-one 3,3,5- trimethyl-5-cyclohexen-1-one 3,3,5- trimethyl-cyclohex-5-en-1-one 3,5,5- trimethylcyclohex-2-en-1-one 3,5,5- trimethylcyclohex-2-enone 3,3,5- trimethylcyclohex-5-en-1-one 3,5,5- trimetil-2-cicloesen-1-one US Patents: 4,010,205 - Process for the preparation of a diketone derivative PubMed: Performance behavior of modified cellulosic fabrics using polyurethane acrylate copolymer. PubMed: Cytocompatibility and osteogenesis evaluation of HA/GCPU composite as scaffolds for bone tissue engineering. PubMed: [Non-taxoid chemical constituents from needles of Taxus cuspidata]. PubMed: Integrating open-source software applications to build molecular dynamics systems. PubMed: Diisocyanate mediated polyether modified gelatin drug carrier for controlled release. PubMed: Sampling of respirable isocyanate particles. PubMed: Testing of glove efficacy against sprayed isocyanate coatings utilizing a reciprocating permeation panel. PubMed: Cross-sectional survey of workers exposed to aliphatic diisocyanates using detailed respiratory medical history and questions regarding accidental skin and respiratory exposures. PubMed: Fabrication and evaluation of physical properties and cytotoxicity of zein-based polyurethanes. PubMed: Interactions between fluorinated cationic guar gum and surfactants in the dilute and semi-dilute solutions. PubMed: Quasi-double-blind screening of semiochemicals for reducing navel orangeworm oviposition on almonds. PubMed: Understanding factors that influence protective glove use among automotive spray painters. PubMed: Silver(I) supramolecular complexes generated from isophorone-based ligands: crystal structures and enhanced nonlinear optical properties through metal complexation. PubMed: Identification of saffron aroma compound β-isophorone (3,5,5-trimethyl-3-cyclohexen-1-one) in some V. vinifera grape varieties. PubMed: Simultaneous interpenetrating silicone hydrogel based on radical/addition polymerization for extended release of ocular therapeutics. PubMed: Dry sampling of gas-phase isocyanates and isocyanate aerosols from thermal degradation of polyurethane. PubMed: Development of semiochemical attractants for monitoring and controlling Chlorophorus caragana. PubMed: Contact allergy to isocyanates after accidental spillage. PubMed: Associating and rheological behaviors of fluorinated cationic guar gum in aqueous solutions. PubMed: Preparation and antibacterial property of waterborne polyurethane/Zn-Al layered double hydroxides/ZnO nanocomposites. PubMed: Allergic skin inflammation induced by chemical sensitizers is controlled by the transcription factor Nrf2. PubMed: Preparation and characterization of poly(pluronic-co-L-lactide) nanofibers for tissue engineering. PubMed: Substituent group variations directing the molecular packing, electronic structure, and aggregation-induced emission property of isophorone derivatives. PubMed: Versatile fabrication of nanocomposite microcapsules with controlled shell thickness and low permeability. PubMed: Microbial transformations of isophorone by Alternaria alternata and Neurospora crassa. PubMed: Physicochemical studies on polyurethane/siloxane cross-linked films for hydrophobic surfaces by the sol-gel process. PubMed: Compatible compositions based on aqueous polyurethane dispersions and sodium alginate. PubMed: The degradation of Isophorone by catalytic wet air oxidation on Ru/TiZrO4. PubMed: Synthesis and evaluation of antibacterial polyurethane coatings made from soybean oil functionalized with dimethylphenylammonium iodide and hydroxyl groups. PubMed: Preparation of water-resistant antifog hard coatings on plastic substrate. PubMed: Transferability of aliphatic isocyanates from recently applied paints to the skin of auto body shop workers. PubMed: Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery. PubMed: Aerobic oxidation of β-isophorone catalyzed by N-hydroxyphthalimide: the key features and mechanism elucidated. PubMed: Migrating components in a polyurethane laminating adhesive identified using gas chromatography/mass spectrometry. PubMed: Preparation and characterization of self-emulsified waterborne nitrocellulose. PubMed: Applicability and robustness of the hen's egg test for analysis of micronucleus induction (HET-MN): results from an inter-laboratory trial. PubMed: Airborne isocyanate exposures in the collision repair industry and a comparison to occupational exposure limits. PubMed: Identification of aroma-active compounds in Jiashi muskmelon juice by GC-O-MS and OAV calculation. PubMed: Utilizing peptidic ordering in the design of hierarchical polyurethane/ureas. PubMed: Occupational contact allergy to monomeric isocyanates. PubMed: New biobased high functionality polyols and their use in polyurethane coatings. PubMed: Volatile organic compounds in headspace over electrical components at 75 to 200°C - part 1. identification of constituents and emission rates. PubMed: Activation of boron nitride nanotubes and their polymer composites for improving mechanical performance. PubMed: Biodegradable polyesterurethanes with shape-memory properties for dexamethasone and aspirin controlled release. PubMed: Toxicity ranking and toxic mode of action evaluation of commonly used agricultural adjuvants on the basis of bacterial gene expression profiles. PubMed: Synthesis and characterization of waterborne polyurethane/Cu(II)-loaded hydroxyapatite nanocomposites with antibacterial activity. PubMed: Electrospun polyurethane fibers for absorption of volatile organic compounds from air. PubMed: Progesterone 5β-reductase of Erysimum crepidifolium: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant protein. PubMed: Special susceptive aqueous ammonia chemi-sensor: extended applications of novel UV-curable polyurethane-clay nanohybrid. PubMed: Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma. PubMed: [PEGylation of polyamidoamine dendrimer and the properties for gene vectors]. PubMed: Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies. PubMed: Polyurethanes as supports for human retinal pigment epithelium cell growth. PubMed: Enhanced gene delivery using biodegradable poly(ester amine)s (PEAs) based on low-molecular-weight polyethylenimine and poly(epsilon-caprolactone)-pluronic-poly(epsilon-caprolactone). PubMed: Biological monitoring for isocyanates. PubMed: Shape-memory anchoring system for bladder sensors. PubMed: Development of a permeation panel to test dermal protective clothing against sprayed coatings. PubMed: Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by H molecular diffusion NMR and F spin diffusion NMR. PubMed: Predicting water sorption and volume swelling in dense polymer systems via computer simulation. PubMed: The synthesis and spectral properties of a stimuli-responsive D-π-A charge transfer dye. PubMed: Composition of sulla (Hedysarum coronarium L.) honey solvent extractives determined by GC/MS: norisoprenoids and other volatile organic compounds. PubMed: Volatile composition screening of Salix spp. nectar honey: benzenecarboxylic acids, norisoprenoids, terpenes, and others. PubMed: Signalling pathway of isophorone diisocyanate-responsive interleukin-8 in airway smooth muscle cells. PubMed: PEG- and PDMAEG-graft-modified branched PEI as novel gene vector: synthesis, characterization and gene transfection. PubMed: Liquid chromatography method to determine polyamines in thermosetting polymers. PubMed: Adsorption efficiency of respirator filter cartridges for isocyanates. PubMed: Influences of hydraulic loading rate on SVOC removal and microbial community structure in drinking water treatment biofilters. PubMed: Contact allergy to epoxy resins--a 10-year study. PubMed: Airborne allergy to isophoronediamine and epoxy resin. PubMed: Application of prepared waterborne polyurethane extended with chitosan to impart antibacterial properties to acrylic fabrics. PubMed: [Determination of nitroaromatics and cyclo ketones in sea water' by gas chromatography coupled with activated carbon fiber solid-phase micro-extraction]. PubMed: Microwave irradiation as a versatile tool for increasing reaction rates and yields in synthesis of optically active polyamides containing flexible L-leucine amino acid. PubMed: Heterogeneously catalyzed asymmetric hydrogenation of C=C bonds directed by surface-tethered chiral modifiers. PubMed: [Determination of isophorone in air of work places with thermal desorption-gas chromatography]. PubMed: Synthesis and characterization of a sterically stabilized polyelectrolyte using isophorone diisocyanate as the coupling reagent. PubMed: An oilwell cement slurry additivated with bisphenol diglycidil ether/isophoronediamine--kinetic analysis and multivariate modelings at slurry/HCl interfaces. PubMed: Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure. PubMed: Conveniently synthesized isophorone dyes for high efficiency dye-sensitized solar cells: tuning photovoltaic performance by structural modification of donor group in donor-pi-acceptor system. PubMed: Porous bioactive scaffold of aliphatic polyurethane and hydroxyapatite for tissue regeneration. PubMed: Fabrication and characterization of ophthalmically compatible hydrogels composed of poly(dimethyl siloxane-urethane)/Pluronic F127. PubMed: New attractants for males of the solanaceous fruit fly Bactrocera latifrons. PubMed: The respiratory local lymph node assay as a tool to study respiratory sensitizers. PubMed: Validation of transferability of DBA derivatization and LC-MS/MS determination method for isocyanates via an interlaboratory comparison. PubMed: Contact sensitization to 4,4'-diaminodiphenylmethane and to isocyanates among general dermatology patients. PubMed: Micromorphology and phase behavior of cationic polyurethane segmented copolymer modified with hydroxysilane. PubMed: Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors. PubMed: The influence of isocyanurate content on the bioperformance of hydrocarbon-based polyurethanes. PubMed: Skin exposure to aliphatic polyisocyanates in the auto body repair and refinishing industry: II. A quantitative assessment. PubMed: Model of drug-loaded fluorocarbon-based micelles studied by electron-spin induced (19)f relaxation NMR and molecular dynamics simulation. PubMed: Preparation of polyurethane nanocapsules by miniemulsion polyaddition. PubMed: Comparison of the volatile composition in thyme honeys from several origins in Greece. PubMed: Model fluorous polyurethane surface modifiers having co-polyoxetane soft blocks with trifluoroethoxymethyl and bromomethyl side chains. PubMed: Th2 Cytokines in Skin Draining Lymph Nodes and Serum IgE Do Not Predict Airway Hypersensitivity to Intranasal Isocyanate Exposure in Mice. PubMed: [Studies on chemical constituents of phenols in fresh Houttuynia cordata]. PubMed: Use of telechelic cis-1,4-polyisoprene cationomers in the synthesis of antibacterial ionic polyurethanes and copolyurethanes bearing ammonium groups. PubMed: Development of a biodegradable bioadhesive containing urethane groups. PubMed: Synthesis, characterization, shrinkage and curing kinetics of a new low-shrinkage urethane dimethacrylate monomer for dental applications. PubMed: Determination of isophorone in food samples by solid-phase microextraction coupled with gas chromatography-mass spectrometry. PubMed: Mechanistic insights into the proline-directed enantioselective heterogeneous hydrogenation of isophorone. PubMed: [Study of pyrolysates of beta-carotene in tobacco]. PubMed: A variety of volatile compounds as markers in unifloral honey from dalmatian sage (Salvia officinalis L.). PubMed: Water makes it hydrophobic: contraphilic wetting for polyurethanes with soft blocks having semifluorinated and 5,5-dimethylhydantoin side chains. PubMed: A method of test for residual isophorone diisocyanate trimer in new polyester-polyurethane coatings on light metal packaging using liquid chromatography with tandem mass spectrometric detection. PubMed: Enantiomerically pure isophorone diamine [3-(aminomethyl)-3,5,5-trimethylcyclohexylamine]: a chiral 1,4-diamine building block made available on large scale. PubMed: Stability studies on colloidal suspensions of polyurethane nanocapsules. PubMed: Hybrid materials covalently incorporated with isophorone-based dyes through sol-gel process for nonlinear optical applications. PubMed: Inconsistencies between cytokine profiles, antibody responses, and respiratory hyperresponsiveness following dermal exposure to isocyanates. PubMed: Generation of saffron volatiles by thermal carotenoid degradation. PubMed: Modification of the biopolymer castor oil with free isocyanate groups to be applied as bioadhesive. PubMed: [Determination of isophorone in air in working places]. PubMed: NMAM methods update: a laboratory response to concerns about technologically outdated and problematic methods. PubMed: Solid-state linear-dichroic IR-spectroscopy of isophorone derivatives with potential non-linear optical application. PubMed: Heterogeneously catalyzed asymmetric C=C hydrogenation: origin of enantioselectivity in the proline-directed Pd/isophorone system. PubMed: An FTIR investigation of isocyanate skin absorption using in vitro guinea pig skin. PubMed: Syntheses and odor of "bulky group"-modified sandalwood odorants: isophorono-beta-santalol analogues. PubMed: Use of SPME-GC-MS in the study of time evolution of the constituents of saffron aroma: modifications of the composition during storage. PubMed: Generation of aroma compounds from Ditaxis heterantha by Saccharomyces cerevisiae. PubMed: Determination of airborne isocyanates generated during the thermal degradation of car paint in body repair shops. PubMed: Polyurethanes containing oxetane-derived poly(2,2-substituted-1,3-propylene oxide) soft blocks: copolymer effect on wetting behavior. PubMed: Chemical analysis of 2,4-toluene diisocyanate, 1,6-hexamethylene diisocyanate and isophorone diisocyanate in petrolatum patch-test preparations. PubMed: Non-targeted multi-component analytical surveillance of plastic food contact materials: Identification of substances not included in EU positive lists and their risk assessment. PubMed: Polyurethane biocidal polymeric surface modifiers. PubMed: Biotransformation of racemic diisophorone by Cephalosporium aphidicola and Neurospora crassa. PubMed: Antifungal activity and biotransformation of diisophorone by Botrytis cinerea. PubMed: Mechanism of the formation of a dehydrated ion by an unusual loss of oxygen at the 4'-carbonyl group of abscisic acid methyl ester in electron ionization mass spectrometry. PubMed: [Determination of isophorone in foods]. PubMed: Identification of natural dyes used in works of art by pyrolysis-gas chromatography/mass spectrometry combined with in situ trimethylsilylation. PubMed: Allergic contact dermatitis from isocyanates among sculptors. PubMed: Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization. PubMed: An attempt to improve diagnostics of contact allergy due to epoxy resin systems. First results of the multicentre study EPOX 2002. PubMed: Synthesis of core-shell polyurethane-urea nanoparticles containing 4,4'-methylenedi-p-phenyl diisocyanate and isophorone diisocyanate by self-assembled neutralization emulsification. PubMed: Synthesis and characterization of novel polyurethane cationomers with dipeptide sequences and alkylammonium groups. PubMed: Pulmonary irritant potency of polyisocyanate aerosols in rats: comparative assessment of irritant threshold concentrations by bronchoalveolar lavage. PubMed: Determination of amines as pentafluoropropionic acid anhydride derivatives in biological samples using liquid chromatography and tandem mass spectrometry. PubMed: Determinants of isocyanate exposures in auto body repair and refinishing shops. PubMed: Sonochemical asymmetric hydrogenation of isophorone on proline modified Pd/Al2O3 catalysts. PubMed: Common shoe allergens undetected by commercial patch-testing kits: dithiodimorpholine and isocyanates. PubMed: Synthesis and characterization of polyurethane and poly(ether urethane) nanocapsules using a new technique of interfacial polycondensation combined to spontaneous emulsification. PubMed: Allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate. PubMed: Evaluation of denuder sampling for a mixture of three common gaseous diisocyanates. PubMed: Old Yellow Enzyme from Candida macedoniensis catalyzes the stereospecific reduction of the C=C bond of ketoisophorone. PubMed: Thresholds of carcinogenicity of flavors. PubMed: Semiochemical strategies for sea louse control: host location cues. PubMed: Combinations of microphase separation and terminal multiple hydrogen bonding in novel macromolecules. PubMed: Diisocyanate emission from a paint product: a preliminary analysis. PubMed: Persistent organic pollutants (POPs) in surface sediments of Donghu Lake, Wuhan, Hubei, China. PubMed: Airborne thermal degradation products of polyurethene coatings in car repair shops. PubMed: Occupational epoxy resin allergic contact dermatitis. PubMed: Spill-induced sensitization to isophoronediamine. PubMed: Linear type azo-containing polyurethane as drug-coating material for colon-specific delivery: its properties, degradation behavior, and utilization for drug formulation. PubMed: Polyurethanes based on dihydroxamic acids. Synthesis, chemical characterization, and biological activity. PubMed: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs. PubMed: Occupational allergic contact dermatitis from isophoronediamine (IPDA) in operative-clothing manufacture. PubMed: Quantitative analysis of polychlorinated biphenyls, organochlorine insecticides, polycyclic aromatic hydrocarbons, polychlorinated hydrocarbons and polynitrohydrocarbons in spiked samples of soil, water and plasma by selected-ion monitoring gas chromatography-mass spectrometry. PubMed: Synthesis and characterization of segmented polyurethanes based on amphiphilic polyether diols. PubMed: Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay "unique positive' NTP carcinogens. PubMed: Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: interim report of an international collaborative study. PubMed: Alpha 2u-globulins in the urine of male rats: a reliable indicator for alpha 2u-globulin accumulation in the kidney. PubMed: Contact dermatitis due to 3-amino-methyl-3,5,5-trimethylcyclohexylamine (isophoronediamine; IPD) PubMed: Total IgE antibody production in BALB/c mice after dermal exposure to chemicals. PubMed: Occupational airborne allergic contact dermatitis due to 3-amino-methyl-3,5,5-trimethylcyclohexylamine. PubMed: Test chamber exposure of humans to 1,6-hexamethylene diisocyanate and isophorone diisocyanate. PubMed: Biological monitoring of hexamethylene- and isophorone-diisocyanate by the determination of hexamethylene- and isophorone-diamine in hydrolysed urine using liquid chromatography and mass spectrometry. PubMed: Biocompatible polyurethane-based hydrogel. PubMed: Occupational airborne allergic contact dermatitis in parquet layers. PubMed: Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin. PubMed: Variable effects of chemical allergens on serum IgE concentration in mice. Preliminary evaluation of a novel approach to the identification of respiratory sensitizers. PubMed: Contact sensitization due to isophoronediamine. PubMed: Occupational asthma caused by a hardener containing an aliphatic and a cycloaliphatic diamine. PubMed: Characterization of murine immune responses to allergenic diisocyanates. PubMed: Erythema multiforme after contact dermatitis in response to an epoxy sealant. PubMed: NCI-Black-Reiter (NBR) male rats fail to develop renal disease following exposure to agents that induce alpha-2u-globulin (alpha 2u) nephropathy. PubMed: Characteristics of chemical binding to alpha 2u-globulin in vitro--evaluating structure-activity relationships. PubMed: Rapid toxicity testing based on mitochondrial respiratory activity. PubMed: Lysosomal degradation of alpha 2u-globulin and alpha 2u-globulin-xenobiotic conjugates. PubMed: Adrenal-dependent leucopenia after short-term exposure to various airborne irritants in rats. PubMed: Effects of selected chemicals on the glutathione status in the male reproductive system of rats. PubMed: DNA binding study of isophorone in rats and mice. PubMed: Contact hypersensitivity response to isophorone diisocyanate in mice. PubMed: Isophoronediamine (IPD) dermatitis in Spain. PubMed: [Contact dermatitis caused by isophorone diamine]. PubMed: Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone, and isophorone. PubMed: Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. PubMed: Mechanical properties and biocompatibility of two polyepoxy matrices: DGEBA-DDM and DGEBA-IPD. PubMed: Toxicology and carcinogenesis studies of isophorone in F344 rats and B6C3F1 mice. PubMed: NTP Toxicology and Carcinogenesis Studies of Isophorone (CAS No. 78-59-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies). PubMed: [Spectrophotometric determination of alpha-isophorone in water]. PubMed: Mutagen production by chlorination of methylated alpha,beta-unsaturated ketones. PubMed: Vapour and liquid diffusion of model penetrants through human skin; correlation with thermodynamic activity. PubMed: Correlation of thermodynamic activity and vapour diffusion through human skin for the model compound, benzyl alcohol. PubMed: Quantitative variation of pheromone components in the spruce bark beetleIps typographus from different attack phases. PubMed: Quantitative evaluation of sensory irritating and neurobehavioural properties of aliphatic ketones in mice. PubMed: Intrinsic color of isophorone polyurethane for maxillofacial prosthetics. Part II: Color stability. PubMed: Intrinsic color of isophorone polyurethane for maxillofacial prosthetics. Part I: Physical properties. PubMed: Toxicity of acenaphthene and isophorone to early life stages of fathead minnows. PubMed: Exposure to isophorone and other organic solvents in a screen printing plant. PubMed: Early life stage toxicity tests with a saltwater fish: effects of eight chemicals on survival growth, and development of sheepshead minnows (Cyprinodon variegatus). PubMed: Isophorone diisocyanate induced respiratory disease (IPDI). PubMed: [Dismutation as a metabolic pathway : transformation of the trimethyl 3,5,5, cyclohexanone (author's transl)]. PubMed: Cross-sensitivity between isophorone diamine (IPD) and isophorone diisocyanate (IPDI). PubMed: [Metabolic transformations of the trimethyl - 3,5,5, cyclohexene-2, one-1 (isophorone) (author's transl)]. PubMed: Occupational allergic contact dermatitis to isophorone diamine (IPD) used as an epoxy resin hardener. PubMed: [Occupational dermatoses due to polyurethane drugs]. PubMed: [Metabolic transformations of 3,5,5-trimethyl-cyclohexanone (dihydro-isophorone). Demonstration of a new metabolic pathway: dismutation]. PubMed: [Toxicity of an industrial solvent, isophorone: irritation power vis-à-vis teguments and mucosa]. PubMed: [1st results of the study of metabolism in rabbits of an industrial solvent: the isophorone]. PubMed: [Vinylogous aminomethylation of isophorone]. PubMed: Determination of small quantities of isophorone in air.