protohypericin
dibenzo(a,o)perylene-7,16-dione, 1,3,4,6,8,15-hexahydroxy-10,11-dimethyl-
Identification
| Name | protohypericin |
| CAS Number | 548-03-8 |
| FDA UNII | Search |
| Molecular Formula | C30 H18 O8 |
| Molecular Weight | 506.46706000 |
| Nikkaji Number | J393.134J |
Regulatory
Physical Properties
| Assay | 90.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 896.90 °C. @ 760.00 mm Hg (est) |
| Flash Point | 950.00 °F. TCC ( 510.10 °C. ) (est) |
| logP (o/w) | 8.870 (est) |
| Soluble in | water, 6.078e-006 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for protohypericin usage levels up to | not for fragrance use. |
| Recommendation for protohypericin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
dibenzo(a,o)perylene-7,16-dione, 1,3,4,6,8,15-hexahydroxy-10,11-dimethyl-
Google Patents:
Methods for preparing hypericin
PubMed:
PAL inhibitor evokes different responses in two Hypericum species.
PubMed:
Anti-influenza virus principles from Muehlenbeckia hastulata.
PubMed:
LC-MS and LC-PDA analysis of Hypericum empetrifolium and Hypericum sinaicum.
PubMed:
Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis.
PubMed:
Determination of enantiomerization barriers of hypericin and pseudohypericin by dynamic high-performance liquid chromatography on immobilized polysaccharide-type chiral stationary phases and off-column racemization experiments.
PubMed:
Study of active naphtodianthrone St John's Wort compounds by electrospray ionization Fourier transform ion cyclotron resonance and multi-stage mass spectrometry in sustained off-resonance irradiation collision-induced dissociation and infrared multiphoton dissociation modes.
PubMed:
Influence of the habitat altitude on the (proto)hypericin and (proto)pseudohypericin levels of hypericum plants from Crete.
PubMed:
Influence of the developmental stage on the (proto)-hypericin and (proto)pseudohypericin levels of Hypericum plants from Crete.
PubMed:
Simultaneous determination of total hypericin and hyperforin in St. John's wort extracts by HPLC with electrochemical detection.
PubMed:
Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS.
PubMed:
A high-performance liquid chromatography with electrochemical detection for the determination of total hypericin in extracts of St. John's Wort.
PubMed:
Simultaneous determination of protopseudohypericin, pseudohypericin, protohypericin, and hypericin without light exposure.
PubMed:
Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives.
PubMed:
Liquid chromatography-mass spectrometry studies of St. John's wort methanol extraction: active constituents and their transformation.
PubMed:
Determination of hypericin content in Hypericum triquetrifolium Turra (Hypericaceae) growing wild in Jordan.
PubMed:
Fast high-performance liquid chromatographic analysis of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts.
PubMed:
Use of an on-line, precolumn photochemical reactor in high-performance liquid chromatography of naphthodianthrones in Hypericum perforatum preparations.
PubMed:
Determination of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts by liquid chromatography/tandem mass spectrometry.
PubMed:
Improved procedure for the quality control of Hypericum perforatum L.
PubMed:
Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow.
PubMed:
Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum).
PubMed:
[Biologically active substances isolated from Hypericum attenuatum Choisy].
PubMed:
Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats.
PubMed:
Photocytotoxicity of protohypericin after photoconversion to hypericin.
PubMed:
In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model.
PubMed:
Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography-electrospray mass spectrometry.
PubMed:
Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus.