protohypericin

dibenzo(a,o)perylene-7,16-dione, 1,3,4,6,8,15-hexahydroxy-10,11-dimethyl-

CAS: 548-03-8 C30 H18 O8 MW: 506.46706000

Identification

Nameprotohypericin
CAS Number548-03-8
FDA UNIISearch
Molecular FormulaC30 H18 O8
Molecular Weight506.46706000
Nikkaji NumberJ393.134J

Regulatory

Physical Properties

Assay 90.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 896.90 °C. @ 760.00 mm Hg (est)
Flash Point 950.00 °F. TCC ( 510.10 °C. ) (est)
logP (o/w) 8.870 (est)
Soluble in water, 6.078e-006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for protohypericin usage levels up tonot for fragrance use.
Recommendation for protohypericin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

st. john's wort

Synonyms

dibenzo(a,o)perylene-7,16-dione, 1,3,4,6,8,15-hexahydroxy-10,11-dimethyl- Google Patents: Methods for preparing hypericin PubMed: PAL inhibitor evokes different responses in two Hypericum species. PubMed: Anti-influenza virus principles from Muehlenbeckia hastulata. PubMed: LC-MS and LC-PDA analysis of Hypericum empetrifolium and Hypericum sinaicum. PubMed: Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. PubMed: Determination of enantiomerization barriers of hypericin and pseudohypericin by dynamic high-performance liquid chromatography on immobilized polysaccharide-type chiral stationary phases and off-column racemization experiments. PubMed: Study of active naphtodianthrone St John's Wort compounds by electrospray ionization Fourier transform ion cyclotron resonance and multi-stage mass spectrometry in sustained off-resonance irradiation collision-induced dissociation and infrared multiphoton dissociation modes. PubMed: Influence of the habitat altitude on the (proto)hypericin and (proto)pseudohypericin levels of hypericum plants from Crete. PubMed: Influence of the developmental stage on the (proto)-hypericin and (proto)pseudohypericin levels of Hypericum plants from Crete. PubMed: Simultaneous determination of total hypericin and hyperforin in St. John's wort extracts by HPLC with electrochemical detection. PubMed: Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS. PubMed: A high-performance liquid chromatography with electrochemical detection for the determination of total hypericin in extracts of St. John's Wort. PubMed: Simultaneous determination of protopseudohypericin, pseudohypericin, protohypericin, and hypericin without light exposure. PubMed: Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives. PubMed: Liquid chromatography-mass spectrometry studies of St. John's wort methanol extraction: active constituents and their transformation. PubMed: Determination of hypericin content in Hypericum triquetrifolium Turra (Hypericaceae) growing wild in Jordan. PubMed: Fast high-performance liquid chromatographic analysis of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts. PubMed: Use of an on-line, precolumn photochemical reactor in high-performance liquid chromatography of naphthodianthrones in Hypericum perforatum preparations. PubMed: Determination of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts by liquid chromatography/tandem mass spectrometry. PubMed: Improved procedure for the quality control of Hypericum perforatum L. PubMed: Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow. PubMed: Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum). PubMed: [Biologically active substances isolated from Hypericum attenuatum Choisy]. PubMed: Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats. PubMed: Photocytotoxicity of protohypericin after photoconversion to hypericin. PubMed: In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model. PubMed: Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography-electrospray mass spectrometry. PubMed: Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus.