picrotoxinin

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(1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxa cyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione

CAS: 17617-45-7 C15 H16 O6 MW: 292.28772000
All Ingredients Aromatic Ingredients CAS Numbers Found in Nature

Identification

Namepicrotoxinin
CAS Number17617-45-7
FDA UNII9K011NUF0R
Molecular FormulaC15 H16 O6
Molecular Weight292.28772000
MDL NumberMFCD00078765

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 551.60 °C. @ 760.00 mm Hg (est)
Flash Point 417.00 °F. TCC ( 214.00 °C. ) (est)
logP (o/w) -0.130 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 8980 ug/kg
Dermal Toxicitysubcutaneous-dog LDLo 1100 ug/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for picrotoxinin usage levels up tonot for fragrance use.
Recommendation for picrotoxinin flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

anamirta cocculus seed

Synonyms

picrotoxinine (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))- hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxa cyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione PubMed: Stability of picrotoxin during yogurt manufacture and storage. PubMed: NOESY on neurotoxins: NMR and conformational assignments of picrotoxins. PubMed: Effects of competitive and noncompetitive GABA(A) antagonists on the acquisition of a discrimination in squirrel monkeys. PubMed: The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is potentiated by bicuculline and picrotoxinin. PubMed: "Central" and "peripheral" benzodiazepines and kinetics of lindane-induced toxicity. PubMed: Clonazepam-induced hyperphagia in nondeprived rats: tests of pharmacological specificity with Ro5-4864, Ro5-3663, Ro15-1788 and CGS 9896.