phyllanthin

benzene, 1,1'-(2,3-bis(methoxymethyl)-1,4-butanediyl)bis(3,4-dimethoxy-, (S-(R*,R*))-

CAS: 10351-88-9 C24 H34 O6 MW: 418.53018000

Identification

Namephyllanthin
IUPAC4-[3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-1,2-dimethoxybenzene
CAS Number10351-88-9
FDA UNII75O1TFF47Z
Molecular FormulaC24 H34 O6
Molecular Weight418.53018000
MDL NumberMFCD17166965
Beilstein2066503

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 530.60 °C. @ 760.00 mm Hg (est)
Flash Point 405.00 °F. TCC ( 207.30 °C. ) (est)
logP (o/w) 4.110 (est)
Soluble in water, 0.4845 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for phyllanthin usage levels up tonot for fragrance use.
Recommendation for phyllanthin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

benzene, 1,1'-(2,3-bis(methoxymethyl)-1,4-butanediyl)bis(3,4-dimethoxy-, (S-(R*,R*))- 4-[3-[(3,4- dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-1,2-dimethoxybenzene 1,1'-[2,3-bis( methoxymethyl)-1,4-butanediyl]bis(3,4-dimethoxybenzene) PubMed: Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF-α/ NF-κB and pro-fibrotic factor TGF-β1 mediated inflammatory signaling. PubMed: Phyllanthus amarus does not affect hypernociception in experimental autoimmune encephalomyelitis. PubMed: Development of phyllanthin-loaded self-microemulsifying drug delivery system for oral bioavailability enhancement. PubMed: Optimization of process variables for phyllanthin extraction from Phyllanthus amarus leaves by supercritical fluid using a Box-Behnken experimental design followed by HPLC identification. PubMed: Inhibitory Effects of Standardized Extracts of Phyllanthus amarus and Phyllanthus urinaria and Their Marker Compounds on Phagocytic Activity of Human Neutrophils. PubMed: Physicochemical characterization of phyllanthin from Phyllanthus amarus Schum. et Thonn. PubMed: Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. PubMed: Growth inhibition of human gynecologic and colon cancer cells by Phyllanthus watsonii through apoptosis induction. PubMed: Hepatoprotective activity of Indian Phyllanthus. PubMed: Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries. PubMed: Enhancing hepatoprotective bioactives of phyllanthus amarus through immobilization by growth promoters and media changes. PubMed: Clonal propagation of Phyllanthus amarus: A hepatoprotector. PubMed: Development of phyllanthin containing microcapsules and their improved biological activity towards skin cells and Staphylococcus aureus. PubMed: Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells. PubMed: Endothelium-independent effects of phyllanthin and hypophyllanthin on vascular tension. PubMed: Phytochemical analysis, antioxidant and anti-inflammatory activities of Phyllanthus simplex. PubMed: Recent advances in herbal medicine for treatment of liver diseases. PubMed: Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition. PubMed: Protective activity of phyllanthin in ethanol-treated primary culture of rat hepatocytes. PubMed: Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line. PubMed: Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. PubMed: Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin. PubMed: Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus. PubMed: Chromium-induced changes in ultramorphology and secondary metabolites of Phyllanthus amarus Schum & Thonn. - an hepatoprotective plant. PubMed: Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. PubMed: Separation and quantification of lignans in Phyllanthus species by a simple chiral densitometric method. PubMed: Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads. PubMed: Determination of four lignans in Phyllanthus niruri L. by a simple high-performance liquid chromatography method with fluorescence detection. PubMed: Analysis of lignans from Phyllanthus niruri L. in plasma using a simple HPLC method with fluorescence detection and its application in a pharmacokinetic study. PubMed: Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography. PubMed: The cytotoxic effect and the multidrug resistance reversing action of lignans from Phyllanthus amarus. PubMed: Antihyperuricemic lignans from the leaves of Phyllanthus niruri. PubMed: High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus. PubMed: Antimicrobial potentiality of Phyllanthus amarus against drug resistant pathogens. PubMed: Comparative pharmacognostic studies of three Phyllanthus species. PubMed: Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus. PubMed: Effect of cadmium on growth, ultramorphology of leaf and secondary metabolites of Phyllanthus amarus Schum. and Thonn. PubMed: Preparation and anti-HIV activities of retrojusticidin B analogs and azalignans. PubMed: In vivo studies of a crude extract of Phyllanthus amarus L. in modifying the genotoxicity induced in Vicia faba L. by tannery effluents. PubMed: 1H- and 13C-nmr assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells. PubMed: Antihepatotoxic principles of Phyllanthus niruri herbs.