neoruscogenin
spirosta-5,25(27)-diene-1beta,3beta-diol
Identification
| Name | neoruscogenin |
| IUPAC | 7,9,13-trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol |
| CAS Number | 17676-33-4 |
| EINECS | 241-660-1 |
| FDA UNII | D4E4KC2TUK |
| Molecular Formula | C27 H40 O4 |
| Molecular Weight | 428.61260000 |
| MDL Number | MFCD00210534 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 566.60 °C. @ 760.00 mm Hg (est) |
| Flash Point | 566.00 °F. TCC ( 296.40 °C. ) (est) |
| logP (o/w) | 4.210 (est) |
| Soluble in | water, 0.07339 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin conditioning |
| Recommendation for neoruscogenin usage levels up to | not for fragrance use. |
| Recommendation for neoruscogenin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
spirosta-5,25(27)-dien-1,3-diol
spirosta-5,25(27)-diene-1beta,3beta-diol
7,9,13-
trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol
PubMed:
The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).
PubMed:
Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells.
PubMed:
High-throughput LC/MS/MS analysis of ruscogenin and neoruscogenin in Ruscus aculeatus L.
PubMed:
Inhibition of proteoglycan synthesis affects neuronal outgrowth and astrocytic migration in organotypic cultures of fetal ventral mesencephalon.
PubMed:
Ruscus aculeatus (butcher's broom). Monograph.
PubMed:
Steroidal saponins from Nolina recurvata stems and their inhibitory activity on cyclic AMP phosphodiesterase.