pyridine, 3-(3,4-dihydro-2H-pyrrol-5-yl)- (9CI)

CAS: 532-12-7 C9 H10 N2 MW: 146.19270000

Identification

Namemyosmine
IUPAC3-(2,3-dihydro-1H-pyrrol-5-yl)pyridine
CAS Number532-12-7
FDA UNII9O0A545W4L
Molecular FormulaC9 H10 N2
Molecular Weight146.19270000
MDL NumberMFCD00052019
Nikkaji NumberJ51.342C
Beilstein0119254

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 318.70 °C. @ 760.00 mm Hg (est)
Flash Point 296.00 °F. TCC ( 146.50 °C. ) (est)
logP (o/w) 0.730 (est)
Soluble in water, 1.003e+005 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-rat LD50 190 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for myosmine usage levels up tonot for fragrance use.
Recommendation for myosmine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

hazelnut papaya leaf papaya plant peanut

Synonyms

3-(2,3- dihydro-1H-pyrrol-5-yl)pyridine pyridine, 3-(1-pyrrolin-2-yl)- pyridine, 3-(3,4-dihydro-2H-pyrrol-5-yl)- (9CI) 3-(1- pyrrolin-2-yl)pyridine PubMed: Simultaneous quantification of tobacco alkaloids and major phase I metabolites by LC-MS/MS in human tissue. PubMed: Determination of Behaviorally Effective Tobacco Constituent Doses in Rats. PubMed: Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats. PubMed: Determination of caffeine, myosmine, and nicotine in chocolate by headspace solid-phase microextraction coupled with gas chromatography-tandem mass spectrometry. PubMed: Physiological and biochemical characterization of a novel nicotine-degrading bacterium Pseudomonas geniculata N1. PubMed: Genetic variation in alkaloid accumulation in leaves of Nicotiana. PubMed: Analysis of refill liquids for electronic cigarettes. PubMed: Piperidine, pyridine alkaloid inhibition of fetal movement in a day 40 pregnant goat model. PubMed: Application of GC-MS/MS for the analysis of tobacco alkaloids in cigarette filler and various tobacco species. PubMed: Effects of myosmine on antioxidative defence in rat liver. PubMed: Nicotine, cotinine, and myosmine determination using polymer films of tailor-designed zinc porphyrins as recognition units for piezoelectric microgravimetry chemosensors. PubMed: Protonating and determining myosmine intactly by association with citrate anion. PubMed: Biodegradation of nicotine by a novel Strain Shinella sp. HZN1 isolated from activated sludge. PubMed: A novel pathway for nicotine degradation by Aspergillus oryzae 112822 isolated from tobacco leaves. PubMed: Inhibition of human aromatase by myosmine. PubMed: Analysis of myosmine, cotinine and nicotine in human toenail, plasma and saliva. PubMed: The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. PubMed: Validation of a GC-FID method for rapid quantification of nicotine in fermented extracts prepared from Nicotiana tabacum fresh leaves and studies of nicotine metabolites. PubMed: Evaluation of the mutagenic effects of myosmine in human lymphocytes using the HPRT gene mutation assay. PubMed: Enhanced radiation damage in irradiated and non-irradiated bystander regions by co-exposure to myosmine. PubMed: [Rapid determination of alkaloids in tobacco using gas chromatography-mass spectrometry with full scan-selected ion monitoring mode]. PubMed: Sequential preconcentration by coupling of field amplified sample injection with pseudo isotachophoresis-acid stacking for analysis of alkaloids in capillary electrophoresis. PubMed: Analyses of tobacco alkaloids by cation-selective exhaustive injection sweeping microemulsion electrokinetic chromatography. PubMed: Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. PubMed: Characterisation of nicotine and related compounds using electrospray ionisation with ion trap mass spectrometry and with quadrupole time-of-flight mass spectrometry and their detection by liquid chromatography/electrospray ionisation mass spectrometry. PubMed: Tissue distribution and excretion of myosmine after i.v. administration to Long-Evans rats using quantitative whole-body autoradiography. PubMed: Genotoxic effects of myosmine in a human esophageal adenocarcinoma cell line. PubMed: Reaction of the tobacco alkaloid myosmine with hydrogen peroxide. PubMed: Nicotine demethylation in Nicotiana cell suspension cultures: N'-formylnornicotine is not involved. PubMed: Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats. PubMed: Metabolism of myosmine in Wistar rats. PubMed: Unifying mechanism for toxicity and addiction by abused drugs: electron transfer and reactive oxygen species. PubMed: Iminium metabolite mechanism for nicotine toxicity and addiction: Oxidative stress and electron transfer. PubMed: Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6. PubMed: Fast analysis of nicotine related alkaloids in tobacco and cigarette smoke by megabore capillary gas chromatography. PubMed: Genotoxic effects of myosmine in human lymphocytes and upper aerodigestive tract epithelial cells. PubMed: Determination of tobacco alkaloids by gas chromatography with nitrogen-phosphorus detection. PubMed: New sources of dietary myosmine uptake from cereals, fruits, vegetables, and milk. PubMed: Nitrosation of dietary myosmine as risk factor of human cancer. PubMed: Distribution of exposure concentrations and doses for constituents of environmental tobacco smoke. PubMed: Use of environmental tobacco smoke constituents as markers for exposure. PubMed: N-Nitrosation of myosmine yields HPB (4-hydroxy-1-(3-pyridyl)-1-butanone) and NNN (N-nitrosonornicotine). PubMed: Evaluation of micellar electrokinetic capillary chromatography for the analysis of selected tobacco alkaloids. PubMed: Exposure to environmental tobacco smoke in sixteen cities in the United States as determined by personal breathing zone air sampling. PubMed: Determination of personal exposure of non-smokers to environmental tobacco smoke in the United States. PubMed: The effect of varying hormonal and precursor supplementations on levels of nicotine and related alkaloids in cell cultures ofNicotiana tabacum. PubMed: Microcirculatory effects of nicotine and related alkaloids. PubMed: Studies on the induction of sister-chromatid exchanges in Chinese hamster ovary cells by various tobacco alkaloids. PubMed: Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine. PubMed: Metabolism in the F344 rat of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen. PubMed: Metabolic beta-hydroxylation and N-oxidation of N'-nitrosonornicotine. PubMed: A convenient synthesis of myosmine. PubMed: Determination of myosmine with o-aminobenzaldehyde. PubMed: Myosmine in cigar tobacco. PubMed: Some comparative observations on l-nicotine and myosmine.