eupafolin

nepetin

CAS: 520-11-6 C16 H12 O7 MW: 316.26604000

Identification

Nameeupafolin
IUPAC2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
CAS Number520-11-6
FDA UNIII3O7LF3GED
Molecular FormulaC16 H12 O7
Molecular Weight316.26604000
Nikkaji NumberJ11.589D
XlogP31.40 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in water, 505.9 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for eupafolin usage levels up tonot for fragrance use.
Recommendation for eupafolin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

rosemary plant sage plant sesame leaf

Synonyms

4H-1- benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy- (9CI) 2-(3,4- dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one flavone, 3',4',5,7-tetrahydroxy-6-methoxy- (8CI) 6- methoxyluteolin nepetin PubMed: HPLC-fingerprints and antioxidant constituents of Phyla nodiflora. PubMed: Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47(phox) pathway. PubMed: Separation of nine compounds from Salvia plebeia R.Br. using two-step high-speed counter-current chromatography with different elution modes. PubMed: Characterisation of polyphenolic compounds in Clerodendrum petasites S. Moore and their potential for topical delivery through the skin. PubMed: Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling. PubMed: Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation. PubMed: One-Step Separation of Four Flavonoids from Herba Salviae Plbeiae by HSCCC. PubMed: Phytochemical and antitrypanosomal investigation of the fractions and compounds isolated from Artemisia elegantissima. PubMed: Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways. PubMed: Eupafolin and Ethyl Acetate Fraction of Kalanchoe gracilis Stem Extract Show Potent Antiviral Activities against Enterovirus 71 and Coxsackievirus A16. PubMed: Flavonoids from the Japanese monotypic genus, Nipponanthemum. PubMed: [Chemical constituents of Eupatorium lindleyanum]. PubMed: Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from Inula viscosa. PubMed: Sesquiterpenes and other constituents from Dendranthema zawadskii var. latilobum. PubMed: Antioxidant, anti-inflammatory and antiproliferative activities of Kalanchoe gracilis (L.) DC stem. PubMed: Eupatorium perfoliatum L.: phytochemistry, traditional use and current applications. PubMed: Cytotoxic compounds from the leaves of Gaillardia aristata Pursh. growing in Egypt. PubMed: Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines. PubMed: An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum. PubMed: Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. PubMed: Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography. PubMed: Eupafolin: Effect on mitochondrial energetic metabolism. PubMed: A novel daucosterol derivative and antibacterial activity of compounds from Arctotis arctotoides. PubMed: Anti-inflammatory activity of flavonoids from Eupatorium arnottianum. PubMed: Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism. PubMed: Topical anti-inflammatory activity of flavonoids and a new xanthone from Santolina insularis. PubMed: [Studies on chemical constituents in bud of Artemisia scoparia (II)]. PubMed: Cytotoxic activity of nepetin, a flavonoid from Eupatorium ballotaefolium HBK. PubMed: Iridoids from Globularia dumulosa. PubMed: Eudesmanolides from Dimerostemma vestitum. PubMed: Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens. PubMed: Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. PubMed: Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate. PubMed: Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. PubMed: Anti-phospholipase A2 and anti-inflammatory activity of Santolina chamaecyparissus. PubMed: Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control. PubMed: Mono- and sesquiterpenes and antifungal constituents from Artemisia species. PubMed: Decreased helenalin-induced cytotoxicity by flavonoids from Arnica as studied in a human lung carcinoma cell line. PubMed: Influence of a series of natural flavonoids on free radical generating systems and oxidative stress. PubMed: New Flavonoid Glycosides from Arnicae Flos DAB 91. PubMed: Flavones and flavonol glycosides from Eupatorium cannabinum L. PubMed: Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation. PubMed: Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala.