3-methoxyflavone
4H-1-benzopyran-4-one, 3-methoxy-2-phenyl-
Identification
| Name | 3-methoxyflavone |
| IUPAC | 3-methoxy-2-phenylchromen-4-one |
| CAS Number | 7245-02-5 |
| FDA UNII | V3ZW15O8B6 |
| Molecular Formula | C16 H12 O3 |
| Molecular Weight | 252.26924000 |
| MDL Number | MFCD00017612 |
| Nikkaji Number | J936I |
| XlogP3 | 3.70 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 408.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | 378.00 °F. TCC ( 192.40 °C. ) (est) |
| logP (o/w) | 2.840 (est) |
| Soluble in | water, 93.57 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 3-methoxyflavone usage levels up to | not for fragrance use. |
| Recommendation for 3-methoxyflavone flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
4H-1-
benzopyran-4-one, 3-methoxy-2-phenyl-
3-
methoxy-2-phenyl-4H-1-benzopyran-4-one
3-
methoxy-2-phenyl-4H-chromen-4-one
3-
methoxy-2-phenylchromen-4-one
PubMed:
HPLC-fingerprints and antioxidant constituents of Phyla nodiflora.
PubMed:
Microbial transformations of 3-methoxyflavone by strains of Aspergillus niger.
PubMed:
Antiinflammatory and antioxidant flavonoids from Helichrysum kraussii and H. odoratissimum flowers.
PubMed:
[Phenolic compounds from Caesalpinia minax].
PubMed:
Apoptosis induced by paclitaxel via Bcl-2, Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition.
PubMed:
Flavonoids, proanthocyanidins, vitamin C, and antioxidant activity of Theobroma grandiflorum (Cupuassu) pulp and seeds.
PubMed:
Highly glycosylated flavonols with an O-linked branched pentasaccharide from Iberis saxatilis (Brassicaceae).
PubMed:
[Chemical constituents from Gentiana striata].
PubMed:
Isoprenylated flavonoid and adipogenesis-promoting constituents of Dodonaea viscosa.
PubMed:
Flavonoids from Sudanese Albizia zygia (Leguminosae, subfamily Mimosoideae), a plant with antimalarial potency.
PubMed:
Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages.
PubMed:
Differential modulation of brainstem phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase 1/2 signaling underlies WIN55,212-2 centrally mediated pressor response in conscious rats.
PubMed:
Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite.
PubMed:
Signaling in H2O2-induced increase in cell proliferation in Barrett's esophageal adenocarcinoma cells.
PubMed:
[Phenolic constituents from stem bark of Morus wittiorum and their anti-inflammation and cytotoxicity].
PubMed:
Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis.
PubMed:
Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species.
PubMed:
Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.
PubMed:
Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38.
PubMed:
[Studies on the chemical constituents from Rhododendron delavayi].
PubMed:
A new sulfated alpha-ionone glycoside from Sonchus erzincanicus Matthews.
PubMed:
Inhibition of xanthine oxidase by Acacia confusa extracts and their phytochemicals.
PubMed:
Functional expression of formyl peptide receptor family in human NK cells.
PubMed:
Syringetin, a flavonoid derivative in grape and wine, induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway.
PubMed:
Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1.
PubMed:
Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
PubMed:
The activation of M1 muscarinic receptor signaling induces neuronal differentiation in pyramidal hippocampal neurons.
PubMed:
Effect of erythromycin on biological activities induced by clostridium perfringens alpha-toxin.
PubMed:
The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.
PubMed:
8-Prenylkaempferol suppresses inducible nitric oxide synthase expression through interfering with JNK-mediated AP-1 pathway in murine macrophages.
PubMed:
Estrogens and genomic instability in human breast cancer cells--involvement of Src/Raf/Erk signaling in micronucleus formation by estrogenic chemicals.
PubMed:
Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase.
PubMed:
Phenolic constituents from the wood of Morus australis with cytotoxic activity.
PubMed:
Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells.
PubMed:
Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production.
PubMed:
The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway.
PubMed:
Chemical constituents from Belamcanda chinensis.
PubMed:
Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling.
PubMed:
Complete assignments of NMR data of 13 hydroxymethoxyflavones.
PubMed:
FP prostanoid receptor-mediated induction of the expression of early growth response factor-1 by activation of a Ras/Raf/mitogen-activated protein kinase signaling cascade.
PubMed:
Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.
PubMed:
Activation of nonsteroidal anti-inflammatory drug-activated gene-1 via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase revealed a isochaihulactone-triggered apoptotic pathway in human lung cancer A549 cells.
PubMed:
Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones.
PubMed:
Role of ERK1/2 signaling pathways in 4-aminopyridine-induced rat pulmonary vasoconstriction.
PubMed:
High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway.
PubMed:
New dihydrochalcones and anti-platelet aggregation constituents from the leaves of Muntingia calabura.
PubMed:
Complement-Inhibiting Constituents of Bridelia ferruginea Stem Bark.
PubMed:
Severity of alcohol-induced painful peripheral neuropathy in female rats: role of estrogen and protein kinase (A and Cepsilon).
PubMed:
p38 mitogen-activated protein kinase contributes to adenosine A1 receptor-mediated synaptic depression in area CA1 of the rat hippocampus.
PubMed:
RanGAP-mediated nuclear protein import in vascular smooth muscle cells is augmented by lysophosphatidylcholine.
PubMed:
Dexamethasone inhibits epidermal growth factor-stimulated gastric epithelial cell proliferation.
PubMed:
Protein kinase A activation down-regulates, whereas extracellular signal-regulated kinase activation up-regulates sigma-1 receptors in B-104 cells: Implication for neuroplasticity.
PubMed:
Cyclooxygenase, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase MAPK, Rho kinase, and Src mediate hydrogen peroxide-induced contraction of rat thoracic aorta and vena cava.
PubMed:
Estradiol protects against ethanol-induced bone loss by inhibiting up-regulation of receptor activator of nuclear factor-kappaB ligand in osteoblasts.
PubMed:
Antioxidant and alpha-amylase inhibitory compounds from aerial parts of Varthemia iphionoides Boiss.
PubMed:
Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen-activated protein kinase-dependent mechanism.
PubMed:
17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.
PubMed:
Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death.
PubMed:
Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling.
PubMed:
Mechanisms underlying lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris sphincter in vitro.
PubMed:
Mechanisms underlying the relaxation induced by isokaempferide from Amburana cearensis in the guinea-pig isolated trachea.
PubMed:
The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek.
PubMed:
Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP).
PubMed:
CCAAT/enhancer binding protein activation by PD98059 contributes to the inhibition of AhR-mediated 3-methylcholanthrene induction of CYP1A1.
PubMed:
Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins.
PubMed:
Corticotropin-releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway.
PubMed:
Identification of the insulin signaling cascade in the regulation of alpha-class glutathione S-transferase expression in primary cultured rat hepatocytes.
PubMed:
Mitogen-activated protein kinase-mediated reinforcement of hippocampal early long-term depression by the type IV-specific phosphodiesterase inhibitor rolipram and its effect on synaptic tagging.
PubMed:
Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals.
PubMed:
Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes.
PubMed:
The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines.
PubMed:
Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6.
PubMed:
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
PubMed:
15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells.
PubMed:
Phenolic antioxidants from the heartwood of Acacia confusa.
PubMed:
Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes.
PubMed:
Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells.
PubMed:
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
PubMed:
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
PubMed:
Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide (SCH66336).
PubMed:
Mitogen-activated protein kinase phosphorylation in the rostral ventrolateral medulla plays a key role in imidazoline (i1)-receptor-mediated hypotension.
PubMed:
Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures.
PubMed:
Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways.
PubMed:
[Studies on the flavonoid constituents in herb of Eremosparton songoricum].
PubMed:
Effect of azelnidipine on angiotensin II-mediated growth-promoting signaling in vascular smooth muscle cells.
PubMed:
N-methyl-D-aspartate and brain-derived neurotrophic factor induce distinct profiles of extracellular signal-regulated kinase, mitogen- and stress-activated kinase, and ribosomal s6 kinase phosphorylation in cortical neurons.
PubMed:
Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways.
PubMed:
Transfected beta3- but not beta2-adrenergic receptors regulate cystic fibrosis transmembrane conductance regulator activity via a new pathway involving the mitogen-activated protein kinases extracellular signal-regulated kinases.
PubMed:
La3+-promoted proliferation is interconnected with apoptosis in NIH 3T3 cells.
PubMed:
Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia.
PubMed:
Cocaine induces apoptosis in fetal rat myocardial cells through the p38 mitogen-activated protein kinase and mitochondrial/cytochrome c pathways.
PubMed:
Molecular dissection of the butyrate action revealed the involvement of mitogen-activated protein kinase in cystic fibrosis transmembrane conductance regulator biogenesis.
PubMed:
Flavonoids from shoots and roots of Trifolium repens (white clover) grown in presence or absence of the arbuscular mycorrhizal fungus Glomus intraradices.
PubMed:
p38 Mitogen-activated protein kinase mediates synergistic induction of inducible nitric-oxide synthase by lipopolysaccharide and interferon-gamma through signal transducer and activator of transcription 1 Ser727 phosphorylation in murine aortic endothelial cells.
PubMed:
Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction.
PubMed:
The role of Rho kinase and extracellular regulated kinase-mitogen-activated protein kinase in alpha2-adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein.
PubMed:
Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis.
PubMed:
C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression.
PubMed:
Stimulation of early gene induction and cell proliferation by lysophosphatidic acid in human amnion-derived WISH cells: role of phospholipase D-mediated pathway.
PubMed:
Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes.
PubMed:
Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process.
PubMed:
Induction of manganese-superoxide dismutase by YS 51, a synthetic 1-(beta-naphtylmethyl)6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline alkaloid: implication for anti-inflammatory actions.
PubMed:
Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors.
PubMed:
Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.
PubMed:
Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation.
PubMed:
Regulation of urokinase plasminogen activator by epigallocatechin-3-gallate in human fibrosarcoma cells.
PubMed:
Endotoxin induces leukocyte transmigration and changes in permeability of the airway epithelium via protein-kinase C and extracellular regulated kinase activation.
PubMed:
Extracellular signal-regulated kinase/mitogen-activated protein kinases block internalization of delta-opioid receptors.
PubMed:
Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death.
PubMed:
Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588.
PubMed:
[Studies on flavonoid constituents of Caragana intermediia].
PubMed:
Extracellular inorganic phosphate regulates gibbon ape leukemia virus receptor-2/phosphate transporter mRNA expression in rat bone marrow stromal cells.
PubMed:
Ceramide is involved in r(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells.
PubMed:
Induction of C-X-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2 pathway.
PubMed:
Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells.
PubMed:
Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells.
PubMed:
Signal transduction underlying carbachol-induced contraction of rat urinary bladder. II. Protein kinases.
PubMed:
Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK.
PubMed:
Role of the small GTPase Rho in modulation of the inwardly rectifying potassium channel Kir2.1.
PubMed:
Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways.
PubMed:
Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway.
PubMed:
Aspirin protects Caco-2 cells from apoptosis after serum deprivation through the activation of a phosphatidylinositol 3-kinase/AKT/p21Cip/WAF1pathway.
PubMed:
Characterization of bradykinin-induced prostaglandin E2 release from cultured rat trigeminal ganglion neurones.
PubMed:
[Studies on chemical constituents of Sorbaria sorbifolia].
PubMed:
Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.
PubMed:
Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils.
PubMed:
Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing.
PubMed:
Activation of CCAAT/enhancer-binding protein beta by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2.
PubMed:
Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence.
PubMed:
Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages.
PubMed:
Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells.
PubMed:
Angiotensin II AT1 receptor stimulates Na+ -K+ATPase activity through a pathway involving PKC-zeta in rat thyroid cells.
PubMed:
Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2.
PubMed:
Activation of the mitogen-activated protein kinase (ERK(1/2)) signaling pathway by cyclic AMP potentiates the neuroprotective effect of the neurotransmitter noradrenaline on dopaminergic neurons.
PubMed:
Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells.
PubMed:
Tonic inhibitory role for cAMP in alpha(1a)-adrenergic receptor coupling to extracellular signal-regulated kinases 1/2.
PubMed:
Lipoteichoic acid-induced cyclooxygenase-2 expression requires activations of p44/42 and p38 mitogen-activated protein kinase signal pathways.
PubMed:
Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes.
PubMed:
Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase.
PubMed:
Activation of extracellular signal-regulated kinases is essential for pressure-induced proliferation of vascular smooth muscle cells.
PubMed:
The unique property of the CC chemokine regakine-1 to synergize with other plasma-derived inflammatory mediators in neutrophil chemotaxis does not reside in its NH2-terminal structure.
PubMed:
Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells.
PubMed:
Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells.
PubMed:
Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF kappa B activation.
PubMed:
Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes.
PubMed:
Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression.
PubMed:
Regulation of extracellular signal-regulated kinase cascades by alpha- and beta-isoforms of the human thromboxane A(2) receptor.
PubMed:
Constituents of Gnetum montanum.
PubMed:
Porins from Salmonella enterica serovar Typhimurium activate the transcription factors activating protein 1 and NF-kappaB through the Raf-1-mitogen-activated protein kinase cascade.
PubMed:
Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages.
PubMed:
Glycyrrhizin and some analogues induce growth of primary cultured adult rat hepatocytes via epidermal growth factor receptors.
PubMed:
Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells.
PubMed:
Control of survival of proliferating L1210 cells by soluble guanylate cyclase and p44/42 mitogen-activated protein kinase modulators.
PubMed:
Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells.
PubMed:
Expression of 74-kDa histidine decarboxylase protein in a macrophage-like cell line RAW 264.7 and inhibition by dexamethasone.
PubMed:
Regulation of p42/p44 MAPK and p38 MAPK by the adenosine A(1) receptor in DDT(1)MF-2 cells.
PubMed:
Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signal-regulated kinase and ornithine decarboxylase.
PubMed:
Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells.
PubMed:
Inhibitory effect of pentalenolactone on vascular smooth muscle cell proliferation.
PubMed:
Mitogen-activated protein kinase inhibitors suppress prostaglandin F(2alpha)-induced myosin-light chain phosphorylation and contraction in iris sphincter smooth muscle.
PubMed:
CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production.
PubMed:
Antimutagens in gaiyou (Artemisia argyi levl. et vant.).
PubMed:
Synthesis and anti-platelet, anti-inflammatory and anti-allergic activities of methoxyisoflavanquinone and related compounds.
PubMed:
T-588 inhibits astrocyte apoptosis via mitogen-activated protein kinase signal pathway.
PubMed:
Substance P induces tumor necrosis factor-alpha release from human skin via mitogen-activated protein kinase.
PubMed:
Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum.
PubMed:
Role of c-Jun N-terminal kinase/p38 stress signaling in 1-beta-D-arabinofuranosylcytosine-induced apoptosis.
PubMed:
Antiviral flavonoid from Pterocaulon sphacelatum, an Australian Aboriginal medicine.
PubMed:
Inhibitory effect of quercetin metabolites and their related derivatives on copper ion-induced lipid peroxidation in human low-density lipoprotein.
PubMed:
Phosphorylation of extracellular signal-regulated kinases 1 and 2 in 3T3-L1 adipocytes by stimulation of beta(3)-adrenoceptor.
PubMed:
Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity.
PubMed:
Bioassays for the detection of growth-promoting agents, veterinary drugs and environmental contaminants in food.
PubMed:
Stimulation by transforming growth factor-alpha of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by alpha- and beta-adrenoceptor agonists.
PubMed:
Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor.
PubMed:
Serotonin 5-HT2A receptor induces TGF-beta1 expression in mesangial cells via ERK: proliferative and fibrotic signals.
PubMed:
Differential regulation of Na+/H+ exchange and DNA synthesis in vascular smooth muscle cells.
PubMed:
Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells.
PubMed:
Acylated flavonoids from pseudognaphalium species
PubMed:
Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937).
PubMed:
Medium change amplifies mitogen-activated protein kinase-mediated prostaglandin E2 synthesis in Swiss 3T3 fibroblasts.
PubMed:
Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.
PubMed:
Differential effects of tyrosine kinase inhibitors and an inhibitor of the mitogen-activated protein kinase cascade on degranulation and superoxide production of human neutrophil granulocytes.
PubMed:
Determination of the effect of 8-O-(2-methyl-2-butenoyl)-5,7-dihydroxy-3-methoxyflavone from Gnaphalium robustum on growth of Escherichia coli K-12 by optical density and electrical conductance measurements.
PubMed:
Chemical constituents of Crotalaria madurensis.
PubMed:
[Isolation, structure, and synthesis of 5,6,7,4'-tetrahydroxy-3'-methoxyflavone (Batatifoline), a new flavone from Mikania batatifolia D.C].
PubMed:
Isolation, structure and synthesis of 4', 5,6,7-tetrahydroxy-3'-methoxyflavone (batatifolin) a new flavone from Mikania batatifolia DC.