mangiferin
9H-xanthen-9-one, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy- (9CI)
Identification
| Name | mangiferin |
| IUPAC | 1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one |
| CAS Number | 4773-96-0 |
| FDA UNII | 1M84LD0UMD |
| Molecular Formula | C19 H18 O11 |
| Molecular Weight | 422.34366000 |
| MDL Number | MFCD00075656 |
| Nikkaji Number | J15.735J |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 842.70 °C. @ 760.00 mm Hg (est) |
| Flash Point | 578.00 °F. TCC ( 303.60 °C. ) (est) |
| logP (o/w) | 0.130 (est) |
| Soluble in | water, 467.8 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin protecting agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-mouse LD50 2300 ug/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin protecting |
| Recommendation for mangiferin usage levels up to | not for fragrance use. |
| Recommendation for mangiferin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
alpizarin
aphloiol
chinomin
chinonin
hedysarid
1,3,6,7-
tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one
9H-
xanthen-9-one, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy- (9CI)
PubMed:
The Rhizome Mixture of Anemarrhena asphodeloides and Coptidis chinensis Ameliorates Acute and Chronic Colitis in Mice by Inhibiting the Binding of Lipopolysaccharide to TLR4 and IRAK1 Phosphorylation.
PubMed:
Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets.
PubMed:
Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways.
PubMed:
Evaluation of extraction methods for preparative scale obtention of mangiferin and lupeol from mango peels (Mangifera indica L.).
PubMed:
Iriflophenone-3-C-glucoside from Cyclopia genistoides: isolation and quantitative comparison of antioxidant capacity with mangiferin and isomangiferin using on-line HPLC antioxidant assays.
PubMed:
The genus Anemarrhena Bunge: A review on ethnopharmacology, phytochemistry and pharmacology.
PubMed:
Ultrasound-assisted extraction of Mangiferin from Mango (Mangifera indica L.) leaves using response surface methodology.
PubMed:
Antioxidant properties and hyphenated HPLC-PDA-MS profiling of Chilean Pica mango fruits (Mangifera indica L. Cv. piqueño).
PubMed:
Beneficial effects of mangiferin isolated from Salacia chinensis on biochemical and hematological parameters in rats with streptozotocin-induced diabetes.
PubMed:
Protective nature of mangiferin on oxidative stress and antioxidant status in tissues of streptozotocin-induced diabetic rats.
PubMed:
Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics.
PubMed:
Mangiferin from Salacia chinensis prevents oxidative stress and protects pancreatic β-cells in streptozotocin-induced diabetic rats.
PubMed:
Comparison of microwave-assisted and conventional extraction of mangiferin from mango (Mangifera indica L.) leaves.
PubMed:
Antioxidant markers based TLC-DPPH differentiation on four commercialized botanical sources of Shankhpushpi (A Medhya Rasayana): A preliminary assessment.
PubMed:
Food ingredient extracts of Cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity.
PubMed:
Polyphenolic and vitamin C contents and antioxidant activities of aqueous extracts from mature-green and ripe fruit fleshes of Mangifera sp.
PubMed:
Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract.
PubMed:
Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage.
PubMed:
Development and application of an enzyme-linked immunosorbent assay for specific detection of mangiferin content in various cultivars of Mangifera indica leaves using anti-mangiferin polyclonal antibody.
PubMed:
Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK.
PubMed:
Mangiferin glucuronidation: important hepatic modulation of antioxidant activity.
PubMed:
Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters.
PubMed:
Anti-diabetic effects of TongGuanWan, a Chinese traditional herbal formula, in C57BL/KsJ-db/db mice.
PubMed:
Identification and quantification of phenolic compounds in bambangan (Mangifera pajang Kort.) peels and their free radical scavenging activity.
PubMed:
Characterization of bioactive compounds from raw and ripe Mangifera indica L. peel extracts.
PubMed:
The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopia genistoides (honeybush tea).
PubMed:
Mango extracts and the mango component mangiferin promote endothelial cell migration.
PubMed:
Influences of harvest date and location on the levels of beta-carotene, ascorbic acid, total phenols, the in vitro antioxidant capacity, and phenolic profiles of five commercial varieties of mango (Mangifera indica L.).
PubMed:
Effect of pre-drying treatments and storage on color and phenolic composition of green honeybush (Cyclopia subternata) herbal tea.
PubMed:
In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity.
PubMed:
Cytoprotective and antigenotoxic potential of Mangiferin, a glucosylxanthone against cadmium chloride induced toxicity in HepG2 cells.
PubMed:
Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract.
PubMed:
Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.).
PubMed:
Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity.
PubMed:
Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms.
PubMed:
Effect of species variation and processing on phenolic composition and in vitro antioxidant activity of aqueous extracts of Cyclopia spp. (Honeybush Tea).
PubMed:
A comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teas.
PubMed:
Evaluation of the genotoxic potential of Mangifera indica L. extract (Vimang), a new natural product with antioxidant activity.
PubMed:
Use of NIRS for quantification of mangiferin and hesperidin contents of dried green honeybush (Cyclopia genistoides) plant material.
PubMed:
Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia.
PubMed:
Phenolic metabolites from honeybush tea (Cyclopia subternata).
PubMed:
Identification of flavonol and xanthone glycosides from mango (Mangifera indica L. Cv. "Tommy Atkins") peels by high-performance liquid chromatography-electrospray ionization mass spectrometry.
PubMed:
Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats.
PubMed:
Isolation and quantitative analysis of phenolic antioxidants, free sugars, and polyols from mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as a nutritional supplement.