liquiritigenin
4H-1-benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-
Identification
| Name | liquiritigenin |
| IUPAC | 7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
| CAS Number | 41680-09-5 |
| FDA UNII | Search |
| Molecular Formula | C15 H12 O4 |
| Molecular Weight | 256.25744000 |
| MDL Number | MFCD00287289 |
| Nikkaji Number | J461.942K |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 529.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 404.00 °F. TCC ( 206.90 °C. ) (est) |
| logP (o/w) | 2.760 (est) |
| Soluble in | water, 873.5 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for liquiritigenin usage levels up to | not for fragrance use. |
| Recommendation for liquiritigenin flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
4H-1-
benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-
4',7-
dihydroxyflavanone
7-
hydroxy-2-(4-hydroxy-phenyl)-chroman-4-one
7-
hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
7-
hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
DL-
liquiritigenin
PubMed:
Liquiritigenin ameliorates TNBS-induced colitis in mice.
PubMed:
Liquiritigenin restores osteoblast damage through regulating oxidative stress and mitochondrial dysfunction.
PubMed:
Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells.
PubMed:
Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells.
PubMed:
Liquiritigenin alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model.
PubMed:
Chiral analytical method development of liquiritigenin with application to a pharmacokinetic study.
PubMed:
Enhanced skin delivery of liquiritigenin and liquiritin-loaded liposome-in-hydrogel complex system.
PubMed:
Liquiritigenin exhibits antitumour action in pituitary adenoma cells via Ras/ERKs and ROS-dependent mitochondrial signalling pathways.
PubMed:
Liquiritigenin prevents Staphylococcus aureus-mediated lung cell injury via inhibiting the production of α-hemolysin.
PubMed:
Isolation of liquiritigenin-4'-apiosyl-glucoside and liquiritin from the root of Glycyrrhiza uralensis by high-performance centrifugal partition chromatography.
PubMed:
In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin.
PubMed:
Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry.
PubMed:
Liquiritigenin inhibits tumor growth and vascularization in a mouse model of HeLa cells.
PubMed:
Facile optimization for chromatographic separation of liquiritin and liquiritigenin.
PubMed:
Liquiritigenin isolated from Glycyrrhiza uralensis stimulates osteoblast function in osteoblastic MC3T3-E1 cells.
PubMed:
Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.
PubMed:
Liquiritigenin inhibits serum-induced HIF-1α and VEGF expression via the AKT/mTOR-p70S6K signalling pathway in HeLa cells.
PubMed:
Liquiritigenin attenuates the learning and memory deficits in an amyloid protein precursor transgenic mouse model and the underlying mechanisms.
PubMed:
C5-hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2.
PubMed:
Liquiritigenin induces tumor cell death through mitogen-activated protein kinase- (MPAKs-) mediated pathway in hepatocellular carcinoma cells.
PubMed:
Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in HeLa Cells.
PubMed:
Simultaneous quantification of paeoniflorin, nobiletin, tangeretin, liquiritigenin, isoliquiritigenin, liquiritin and formononetin from Si-Ni-San extract in rat plasma and tissues by liquid chromatography-tandem mass spectrometry.
PubMed:
[C-ring cleavage of liquiritigenin extracted from licorice roots by an oxygen-tolerant bovine rumen bacterium strain Aeroto-Niu-O16].
PubMed:
Promotion of rat brain-derived progenitor cell neurogenesis by liquiritigenin treatment: underlying mechanisms.
PubMed:
Inhibitory effect of liquiritigenin on migration via downregulation proMMP-2 and PI3K/Akt signaling pathway in human lung adenocarcinoma A549 cells.
PubMed:
Effects of liquiritigenin treatment on the learning and memory deficits induced by amyloid beta-peptide (25-35) in rats.
PubMed:
Liquiritigenin derivatives and their hepatotoprotective activity.
PubMed:
Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential.
PubMed:
Liquiritigenin decreases selective molecular and behavioral effects of cocaine in rodents.
PubMed:
Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation.
PubMed:
Liquiritigenin pharmacokinetics in a rat model of diabetes mellitus induced by streptozotocin: greater formation of glucuronides in the liver, especially M2, due to increased hepatic uridine 5'-diphosphoglucuronic acid level.
PubMed:
Liquiritigenin inhibits Abeta(25-35)-induced neurotoxicity and secretion of Abeta(1-40) in rat hippocampal neurons.
PubMed:
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats.
PubMed:
Pharmacokinetics and first-pass effects of liquiritigenin in rats: low bioavailability is primarily due to extensive gastrointestinal first-pass effect.
PubMed:
Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives.
PubMed:
RETRACTED: Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation.
PubMed:
Inhibition of hepatoma 22 tumor by Liquiritigenin.
PubMed:
Effect of liquiritigenin, a flavanone existed from Radix glycyrrhizae on pro-apoptotic in SMMC-7721 cells.
PubMed:
Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.
PubMed:
Pharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats with acute hepatitis induced by d-galactosamine/lipopolysaccharide or CCl(4).
PubMed:
Pharmacokinetic interaction between liquiritigenin (LQ) and DDB: increased glucuronidation of LQ in the liver possibly due to increased hepatic blood flow rate by DDB.
PubMed:
Pharmacokinetics of liquiritigenin in mice, rats, rabbits, and dogs, and animal scale-up.
PubMed:
Deglycosylation of liquiritin strongly enhances its inhibitory potential towards UDP-glucuronosyltransferase (UGT) isoforms.
PubMed:
Synaptodendritic recovery following HIV Tat exposure: neurorestoration by phytoestrogens.
PubMed:
Pharmacokinetics of isoliquiritigenin and its metabolites in rats: low bioavailability is primarily due to the hepatic and intestinal metabolism.
PubMed:
Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production.
PubMed:
Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101.
PubMed:
Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, does not.
PubMed:
Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes.
PubMed:
In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis.
PubMed:
Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist.
PubMed:
Pharmacokinetic study of four flavones of Glycyrrhiza in rat plasma using HPLC-MS.
PubMed:
Therapeutic significance of estrogen receptor β agonists in gliomas.
PubMed:
Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis.
PubMed:
One step isolation and purification of liquiritigenin and isoliquiritigenin from Glycyrrhiza uralensis Risch. using high-speed counter-current chromatography.
PubMed:
Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection.
PubMed:
Estrogen receptor β agonists affect growth and gene expression of human breast cancer cell lines.
PubMed:
Simultaneous quantitative determination of nine active chemical compositions in traditional Chinese medicine Glycyrrhiza by RP-HPLC with full-time five-wavelength fusion method.
PubMed:
Permeability of the flavonoids liquiritigenin and its glycosides in licorice roots and davidigenin, a hydrogenated metabolite of liquiritigenin, using human intestinal cell line Caco-2.
PubMed:
Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage).
PubMed:
Multiple systems for the biliary excretion of organic anions in rats: liquiritigenin conjugates as model compounds.
PubMed:
Identification of tissues responsible for the conjugative metabolism of liquiritigenin in rats: an analysis based on metabolite kinetics.
PubMed:
Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens.
PubMed:
[Anti-inflammation of flavonoid compounds from Dalbergia odorifera T. Chen in lipopolysaccharide stimulated RAW264.7 macrophages].
PubMed:
Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells.
PubMed:
Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine.
PubMed:
Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo.
PubMed:
Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMIâ¢, inhibit memory Th2 responses in vitro and in vivo.
PubMed:
Content determination of the major constituents of Yinchenzhufu decoction via ultra high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry.
PubMed:
Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species.
PubMed:
Quantification of three chiral flavonoids with reported bioactivity in selected licensed Canadian natural health products and US marketed dietary supplements.
PubMed:
Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
PubMed:
Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid.
PubMed:
Distribution patterns of the contents of five active components in taproot and stolon of Glycyrrhiza uralensis.
PubMed:
Correlation analysis between the rate of respiration in the root and the active components in licorice (Glycyrrhiza uralensis).
PubMed:
The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry.
PubMed:
Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol.
PubMed:
[On-line sample stacking for the analysis of glycyrrhiza flavonoids by anion selective exhaustive injection-sweeping micellar electrokinetic chromatography].
PubMed:
Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC-MS, LC-MS and 1D NMR techniques.
PubMed:
Estrogen receptor β agonist enhances temozolomide sensitivity of glioma cells by inhibiting PI3K/AKT/mTOR pathway.
PubMed:
[Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration].
PubMed:
Photosynthetic Bradyrhizobium Sp. strain ORS285 synthesizes 2-O-methylfucosylated lipochitooligosaccharides for nod gene-dependent interaction with Aeschynomene plants.
PubMed:
LC-MS/MS analysis of Gegen Qinlian Decoction and its pharmacokinetics after oral administration to rats.
PubMed:
Effect of genotype and environment on five bioactive components of cultivated licorice (Glycyrrhiza uralensis FISCH.) populations in northern China.
PubMed:
The effects of Glycyrrhizae uralenis and its major bioactive components on pharmacokinetics of daphnetin in Cortex daphnes in rats.
PubMed:
Preparative isolation and analysis of alcohol dehydrogenase inhibitors from Glycyrrhiza uralensis root using ultrafiltration combined with high-performance liquid chromatography and high-speed countercurrent chromatography.
PubMed:
Simultaneous Determination of 12 Index Components and Compatibility Changes in Longchai Decoction by Liquid Chromatography-Mass Spectrometry.
PubMed:
Computer-guided approach to access the anti-influenza activity of licorice constituents.
PubMed:
LC-ESI-MS characterisation of phytoalexins induced in chickpea and pea tissues in response to a biotic elicitor of Hypnea musciformis (red algae).
PubMed:
Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.
PubMed:
[Studies on effects of Achyranthes bidentata on tongsaimai pellets main active ingredients chlorogenic acid, isoliquiritin, harpagoside and glycyrrhizin in vivo pharmacokinetics].
PubMed:
Simultaneous Quantification of Ten Active Components in Traditional Chinese Formula Sijunzi Decoction Using a UPLC-PDA Method.
PubMed:
Identification of key licorice constituents which interact with cytochrome P450: evaluation by LC/MS/MS cocktail assay and metabolic profiling.
PubMed:
Screening and determination for potential α-glucosidase inhibitory constituents from Dalbergia odorifera T. Chen using ultrafiltration-LC/ESI-MS(n).
PubMed:
Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens.
PubMed:
Simultaneous determination of five bioactive components in radix glycyrrhizae by pressurised liquid extraction combined with UPLC-PDA and UPLC/ESI-QTOF-MS confirmation.
PubMed:
Expression of flavonoid 6-hydroxylase candidate genes in normal and mutant soybean genotypes for glycitein content.
PubMed:
Employing bifunctional enzymes for enhanced extraction of bioactives from plants: flavonoids as an example.
PubMed:
Pharmacokinetic comparisons of different combinations of Shaoyao-Gancao-Decoction in rats: simultaneous determination of ten active constituents by HPLC-MS/MS.
PubMed:
[Chemical constituents from the twigs and leaves of Melodinus suaveolens].
PubMed:
Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
PubMed:
[Chemical constituents and activities of total flavonoids from Yushen Tang].
PubMed:
Estradiol antagonism of glucocorticoid-induced GILZ expression in human uterine epithelial cells and murine uterus.
PubMed:
Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry.
PubMed:
Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses.
PubMed:
[Studies on the flavonoids from Lignum Dalbergiae Odoriferae (II)].
PubMed:
Determination of flavonoids in licorice using acid hydrolysis and reversed-phase HPLC and evaluation of the chemical quality of cultivated licorice.
PubMed:
[Chemical constituents from the fruits of Areca catechu].
PubMed:
Chemical constituents of Spatholobus suberectus.
PubMed:
Fermentation improves anti-inflammatory effect of sipjeondaebotang on LPS-stimulated RAW 264.7 cells.
PubMed:
Traditional chinese medicine for senile dementia.
PubMed:
Pharmacokinetic and pharmacodynamic profiles of the antitussive principles of Glycyrrhizae radix (licorice), a main component of the Kampo preparation Bakumondo-to (Mai-men-dong-tang).
PubMed:
Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands.
PubMed:
Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists.
PubMed:
Antibacterial activity of the flavonoids from Dalbergia odorifera on Ralstonia solanacearum.
PubMed:
[Study on HPLC chromatographic fingerprint of anti-tumor active site SSCE of Caulis spatholobi].
PubMed:
[Chemical constituents from the roots of Hedysarum polybotrys].
PubMed:
Cuban and Brazilian red propolis: botanical origin and comparative analysis by high-performance liquid chromatography-photodiode array detection/electrospray ionization tandem mass spectrometry.
PubMed:
Screening of herbal constituents for aromatase inhibitory activity.
PubMed:
20S proteasome inhibitory activity of flavonoids isolated from Spatholobus suberectus.
PubMed:
Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro.
PubMed:
In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components.
PubMed:
Phytoestrogenic compounds in alfalfa sprout (Medicago sativa) beyond coumestrol.
PubMed:
Simultaneous determination of five flavonoids in licorice using pressurized liquid extraction and capillary electrochromatography coupled with peak suppression diode array detection.
PubMed:
Fuscacarpans A-C, new pterocarpans from the stems of Erythrina fusca.
PubMed:
[Studies on changes of in vitro and in vivo material base of Shaoyao Gancao decoction based on HPLC-DAD-ESI-MS].
PubMed:
Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2.
PubMed:
Prolyl endopeptidase inhibitory activity of fourteen Kampo formulas and inhibitory constituents of Tokaku-joki-to.
PubMed:
Flavone synthase II (CYP93B16) from soybean (Glycine max L.).
PubMed:
[Two new flavanone glycosides from Glycyrrhizia inflata].
PubMed:
Aldose reductase inhibitory compounds from Glycyrrhiza uralensis.
PubMed:
Interactions between thrombin and natural products of Millettia nitita var. hirsutissima using capillary zone electrophoresis.
PubMed:
Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium.
PubMed:
Separation, characterization and dose-effect relationship of the PPARgamma-activating bio-active constituents in the Chinese herb formulation 'San-Ao decoction'.
PubMed:
In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca.
PubMed:
NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract.
PubMed:
Phytochemical analysis of young fustic (Cotinus coggygria heartwood) and identification of isolated colourants in historical textiles.
PubMed:
Bioactive flavonoids of the flowers of Butea monosperma.
PubMed:
Survey of Glycyrrhizae Radix resources in Mongolia: chemical assessment of the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhizea Radix.
PubMed:
[Studies on chemical constituents of Heterosmilax yunnanensis].
PubMed:
[Effect of rare-earth element Eu3+ on callus growth and flavonoids content in Glycyrrhiza uralensis].
PubMed:
[Studies on chemical constituents from the root of Polygonatum kingianum].
PubMed:
[Chemical components of decoction of radix Paeoniae and radix Glycyrrhizae].
PubMed:
An overexpression of chalcone reductase of Pueraria montana var. lobata alters biosynthesis of anthocyanin and 5'-deoxyflavonoids in transgenic tobacco.
PubMed:
An isoflavone from Pterocarpus santalinus.
PubMed:
Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean.
PubMed:
Intermolecular interactions identify ligand-selective activity of estrogen receptor alpha/beta dimers.
PubMed:
Inactivation of pea genes by RNAi supports the involvement of two similar O-methyltransferases in the biosynthesis of (+)-pisatin and of chiral intermediates with a configuration opposite that found in (+)-pisatin.
PubMed:
Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases.
PubMed:
Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers.
PubMed:
Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase.
PubMed:
Characteristics of delayed excretion of flavonoids in human urine after administration of Shosaiko-to, a herbal medicine.
PubMed:
Stimulation of chalcone synthase activity by yeast extract in cultured Glycyrrhiza echinata cells and 5-deoxyflavanone formation by isolated protoplasts.
PubMed:
Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora.
PubMed:
Cloning and functional expression of a cytochrome P450 cDNA encoding 2-hydroxyisoflavanone synthase involved in biosynthesis of the isoflavonoid skeleton in licorice.
PubMed:
Reaction mechanism of oxidative rearrangement of flavanone in isoflavone biosynthesis.
PubMed:
Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABA(B) receptor.
PubMed:
Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
PubMed:
Biosynthesis of 5-deoxyflavanones in microorganisms.
PubMed:
Aromatase inhibition by bioavailable methylated flavones.
PubMed:
Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information.
PubMed:
[Relative adscriptions of components in the effective fractions of Yinqiao decoction and its composing individual herbs].
PubMed:
Allergy-preventive flavonoids from Xanthorrhoea hastilis.
PubMed:
Simultaneous quantification of multiple licorice flavonoids in rat plasma.
PubMed:
Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells.
PubMed:
Silencing the flavonoid pathway in Medicago truncatula inhibits root nodule formation and prevents auxin transport regulation by rhizobia.
PubMed:
[Chromatographic fingerprint of Dalbergia odorifera and its application in the identification of the crude drugs of different origins].
PubMed:
Norditerpenoid alkaloids and other components from the processed tubers of Aconitum carmichaeli.
PubMed:
Isoflavonoids isolated from Cuban propolis.
PubMed:
Binding of phytoestrogens to rat uterine estrogen receptors and human sex hormone-binding globulins.
PubMed:
Simultaneous determination of 10 major flavonoids in Dalbergia odorifera by high performance liquid chromatography.
PubMed:
Cytotoxic flavonoids from Platymiscium floribundum.
PubMed:
[Studies on chemical constituents of sini tang].
PubMed:
[Studies on the chemical constituents of Lycianthes biflora].
PubMed:
Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase.
PubMed:
The herbal medicine Shosaiko-to exerts different modulating effects on lung local immune responses among mouse strains.
PubMed:
Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis.
PubMed:
Azorhizobium caulinodans ORS571 colonizes the xylem of Arabidopsis thaliana.
PubMed:
Modulation of lung local immune responses by oral administration of a herbal medicine Sho-saiko-to.
PubMed:
Identification of a cytochrome P450 cDNA encoding (2S)-flavanone 2-hydroxylase of licorice (Glycyrrhiza echinata L.; Fabaceae) which represents licodione synthase and flavone synthase II.
PubMed:
A strategy for discovering biologically active compounds with high probability in traditional Chinese herb remedies: an application of saiboku-to in bronchial asthma.
PubMed:
2-Hydroxyisoflavanone dehydratase is a critical determinant of isoflavone productivity in hairy root cultures of Lotus japonicus.
PubMed:
Orthogonal array design for optimizing extraction efficiency of active constituents from Jakyak-Gamcho Decoction, the complex formula of herbal medicines, Paeoniae Radix and Glycyrrhizae Radix.
PubMed:
Simultaneous quantification of flavonoids and triterpenoids in licorice using HPLC.
PubMed:
Application of LC/MS and ICP/MS for establishing the fingerprint spectrum of the traditional Chinese medicinal preparation Gan-Lu-Yin.
PubMed:
CYP3A4 inhibitors isolated from Licorice.
PubMed:
Attractive properties of an isoflavonoid found in white clover root nodules on the clover root weevil.
PubMed:
New metabolic pathways for flavanones catalyzed by rat liver microsomes.
PubMed:
[Isolation and elucidation of chemical constituents with antiviral action from yinqiaosan on influenza virus].
PubMed:
[Studies on flavonoid constituents of Caragana intermediia].
PubMed:
Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats.
PubMed:
Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites.
PubMed:
Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography.
PubMed:
New scheme of the biosynthesis of formononetin involving 2,7,4'-trihydroxyisoflavanone but not daidzein as the methyl acceptor.
PubMed:
Pharmacological effects of urinary products obtained after treatment with saiboku-to, a herbal medicine for bronchial asthma, on type IV allergic reaction.
PubMed:
Minor phenolics from Crinum bulbispermum bulbs.
PubMed:
Chiral resolution of four major flavanones in post-administrative urine of Chinese herbal medicines by HPLC on macroporous silica gel coated with cellulose tris(3,5-dimethylphenylcarbamate).
PubMed:
Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera.
PubMed:
Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine.
PubMed:
Biliary excretion of glycyrrhizin in rats: kinetic basis for multiplicity in bile canalicular transport of organic anions.
PubMed:
Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro.
PubMed:
Licodione Synthase, a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone, in Cultured Glycyrrhiza echinata L. Cells.
PubMed:
Inhibitory effects of some natural products on the activation of hyaluronidase and their anti-allergic actions.
PubMed:
[Chemical studies of coumarins from Glycyrrhiza uralensis Fisch].
PubMed:
[Quality evaluation of Chinese licorice].
PubMed:
Purification and kinetic properties of chalcone-flavanone isomerase from soya bean.