acacetin-7-O-rutinoside

CAS: 480-36-4 C28 H32 O14 MW: 592.55184000

Identification

Namelinarin
IUPAC5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
CAS Number480-36-4
EINECS207-547-6
FDA UNIIHBH2I685IU
Molecular FormulaC28 H32 O14
Molecular Weight592.55184000
MDL NumberMFCD00151178
Nikkaji NumberJ6.164F

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in water, 415.9 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for linarin usage levels up tonot for fragrance use.
Recommendation for linarin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

basswood leaf horsemint plant linaria japonica leaf water mint plant

Synonyms

acacetin 7-O-rutinoside acacetin-7-O-rutinoside acacetin-7-rutinoside acaciin 7-((6-O-(6- deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one 5,7- dihydroxy-4'-methoxyflavone-D-glucosido-L-rhamnoside 5- hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one PubMed: Protective effect of linarin against d-galactosamine and lipopolysaccharide-induced fulminant hepatic failure. PubMed: Effects of piperine on the intestinal permeability and pharmacokinetics of linarin in rats. PubMed: [Optimization of hydrolysis process of linarin using response surface methodology and research about ARI activity of glycosylation-acacetin]. PubMed: Simultaneous determination of linarin, naringenin and formononetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Bushen Guchi Pill. PubMed: Determination and pharmacokinetics of linarin in rat plasma after intramuscular administration of linarin solution and Yejuhua injection by HPLC. PubMed: Rapid LC-MS/MS determination and pharmacokinetic application of linarin in rat plasma. PubMed: Phytochemical linarin enriched in the flower of Chrysanthemum indicum inhibits proliferation of A549 human alveolar basal epithelial cells through suppression of the Akt-dependent signaling pathway. PubMed: Virtual screening studies reveal linarin as a potential natural inhibitor targeting CDK4 in retinoblastoma. PubMed: Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid-β-induced neuronal cell death. PubMed: Linarin isolated from Buddleja officinalis prevents hydrogen peroxide-induced dysfunction in osteoblastic MC3T3-E1 cells. PubMed: [Determination of chlorogenic acid, caffeic acid and linarin in Flos Chrysanthemi Indici from different places by RP-hPLC]. PubMed: [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method]. PubMed: Identification and quantification of the sedative and anticonvulsant flavone glycoside from Chrysanthemum boreale. PubMed: The effect of linarin on LPS-induced cytokine production and nitric oxide inhibition in murine macrophages cell line RAW264.7. PubMed: Analgesic and antipyretic activities of an aqueous extract and of the flavone linarin of Buddleia cordata. PubMed: Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. PubMed: [Determination of linarin in Yuye Jiedu granule by RP-HPLC]. PubMed: A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata. PubMed: A gradient HPLC method for the quality control of chlorogenic acid, linarin and luteolin in Flos Chrysanthemi Indici suppository. PubMed: Determination of the flavonoids/antioxidant levels in Cirsium oleraceum and Cirsium rivulare extracts with cerium(IV)-rhodamine 6G chemiluminescence detection. PubMed: Semisynthesis of linarin, acacetin, and 6-iodoapigenin derivatives from diosmin. PubMed: Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis. PubMed: Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. PubMed: Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice. PubMed: Corn mint (Mentha arvensis) extract diminishes acute Chlamydia pneumoniae infection in vitro and in vivo. PubMed: Development of a rapid resolution liquid chromatography-diode array detector method for the determination of three compounds in Ziziphora clinopodioides Lam from different origins of Xinjiang. PubMed: [Linarin-isovalerianate, a currently unknown flavonoid from Valeriana wallichii D.C. 6. Report on the active substances of Valeriana]. PubMed: [Investigations on the glycosides of acacetin. II. Note on the identity of acaciin from Robinia pseudoacacia L. with linarin from Linaria vulgaris Mill]. PubMed: [On the additional occurrence of pectolinarin and linarin in the plant kingdom. I. On the Compositae and Papilionaceae flavones]. PubMed: [Simultaneous determination of eight active components in Chrysanthemum indicum by HPLC]. PubMed: Comprehensive analysis of Cirsium spinosissimum Scop., a wild alpine food plant. PubMed: Shensong Yangxin Capsule prevents diabetic myocardial fibrosis by inhibiting TGF-β1/Smad signaling. PubMed: Photoprotection of Buddleja cordata extract against UVB-induced skin damage in SKH-1 hairless mice. PubMed: Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor. PubMed: Combined antihypertensive effect of luteolin and buddleoside enriched extracts in spontaneously hypertensive rats. PubMed: [Flavonoid glycosides from leaves of Turpinia arguta and their anti-inflammatory activity]. PubMed: Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris. PubMed: [Study on chemical components of Aconitum flavum and their inflammatory and analgesic effects]. PubMed: Simultaneous quantification and validation of caffeoylquinic acids and flavonoids in Hemistepta lyrata and peroxynitrite-scavenging activity. PubMed: Anti-Inflammatory Effect of Supercritical-Carbon Dioxide Fluid Extract from Flowers and Buds of Chrysanthemum indicum Linnén. PubMed: [Chemical constituents and activities of total flavonoids from Yushen Tang]. PubMed: Simultaneous analysis of 11 main active components in Cirsium setosum based on HPLC-ESI-MS/MS and combined with statistical methods. PubMed: Chemical fingerprinting by RP-RRLC-DAD and principal component analysis of Ziziphora clinopodioides from different locations. PubMed: Photoprotective activity of Buddleja scordioides. PubMed: Protective effect of Calamintha officinalis Moench leaves against alcohol-induced gastric mucosa injury in rats. Macroscopic, histologic and phytochemical analysis. PubMed: Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation. PubMed: [Chemical constituents from n-butanol extract of aerial part of Polygala sibirica]. PubMed: Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes. PubMed: In vitro evaluation of the amebicidal activity of Buddleia cordata (Loganiaceae, H.B.K.) on several strains of Acanthamoeba. PubMed: Phytochemical investigation and biological studies of Bombax malabaricum flowers. PubMed: [Studies on the chemical constituents from Lobelia chinensis]. PubMed: Differentiation of Cirsium japonicum and C. setosum by TLC and HPLC-MS. PubMed: [Studies on chemical components of Lobelia chinensis]. PubMed: Alpha-glucosidase inhibitory constituents of Linaria kurdica subsp. eriocalyx. PubMed: Pro-cognitive effects of Cirsium rivulare extracts in rats. PubMed: Different flavonoids present in the micronized purified flavonoid fraction (Daflon 500 mg) contribute to its anti-hyperpermeability effect in the hamster cheek pouch microcirculation. PubMed: Two-dimensional liquid chromatography coupled with mass spectrometry for the analysis of Lobelia chinensis Lour. using an ESI/APCI multimode ion source. PubMed: Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis. PubMed: [Studies on antiviral flavonoids in yinqiaosan powder]. PubMed: [Simultaneous determination of six flavonoids in Flos Chrysanthemi Indici by RP-HPLC]. PubMed: [Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium)]. PubMed: Central nervous system depressant action of flavonoid glycosides. PubMed: Separation and purification of rutin and acaciin from the chinese medicinal herb Herba Cirsii by combination of macroporous absorption resin and high-speed counter-current chromatography. PubMed: [Studies on involatile constituents of Mentha haplocalyx]. PubMed: Chemical fingerprinting of valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection. PubMed: [Studies on constituents in herb of Senecio scandens]. PubMed: Antihepatotoxic activity and chemical constituents of Buddleja asiatica Lour. PubMed: A new ferulic acid ester and other constituents from Dracocephalum peregrinum. PubMed: [Separation and identification of the flavonoids from Buddleia officinalis Maxim]. PubMed: Assessing the antioxidative properties and chemical composition of Linaria vulgaris infusion. PubMed: [Studies on chemical constituents from flowers of Chrysanthemum indicum]. PubMed: [Relative adscriptions of components in the effective fractions of Yinqiao decoction and its composing individual herbs]. PubMed: [Studies on the chemical constituents of Cirsium japonicum DC]. PubMed: [Studies on the flavonoids from Dendranthema lavandulifolium]. PubMed: [Chemical constituents from Cirsium pendulum Fisch. ex DC]. PubMed: [Study on the active components of Nardostachys chinensis]. PubMed: [Studies on chemical constituents of Paederia scandense]. PubMed: Flavonoid compounds from the flowers of Cirsium rivulare (Jacq.) All. PubMed: [Coulometric titration of acaciin in Chrysanthemum indicum].