hypophyllanthin
naphtho(1,2-d)-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7S,8S,9R)-
Identification
| Name | hypophyllanthin |
| IUPAC | (7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole |
| CAS Number | 33676-00-5 |
| FDA UNII | 22ZZ21E33P |
| Molecular Formula | C24 H30 O7 |
| Molecular Weight | 430.49750000 |
| MDL Number | MFCD03424459 |
| Nikkaji Number | J238.475B |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 511.10 °C. @ 760.00 mm Hg (est) |
| Flash Point | 393.00 °F. TCC ( 200.80 °C. ) (est) |
| logP (o/w) | 3.770 (est) |
| Soluble in | water, 0.5452 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for hypophyllanthin usage levels up to | not for fragrance use. |
| Recommendation for hypophyllanthin flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Potential Uses
Natural Occurrence
Synonyms
(7R,8R,9S)-9-(3,4-
dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole
hypophyllantin
naphtho(1,2-d)-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7S,8S,9R)-
PubMed:
Inhibitory Effects of Standardized Extracts of Phyllanthus amarus and Phyllanthus urinaria and Their Marker Compounds on Phagocytic Activity of Human Neutrophils.
PubMed:
Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells.
PubMed:
Hepatoprotective activity of Indian Phyllanthus.
PubMed:
Enhancing hepatoprotective bioactives of phyllanthus amarus through immobilization by growth promoters and media changes.
PubMed:
Clonal propagation of Phyllanthus amarus: A hepatoprotector.
PubMed:
Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells.
PubMed:
Endothelium-independent effects of phyllanthin and hypophyllanthin on vascular tension.
PubMed:
Recent advances in herbal medicine for treatment of liver diseases.
PubMed:
Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition.
PubMed:
Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents.
PubMed:
Chromium-induced changes in ultramorphology and secondary metabolites of Phyllanthus amarus Schum & Thonn. - an hepatoprotective plant.
PubMed:
Separation and quantification of lignans in Phyllanthus species by a simple chiral densitometric method.
PubMed:
Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads.
PubMed:
Determination of four lignans in Phyllanthus niruri L. by a simple high-performance liquid chromatography method with fluorescence detection.
PubMed:
Analysis of lignans from Phyllanthus niruri L. in plasma using a simple HPLC method with fluorescence detection and its application in a pharmacokinetic study.
PubMed:
Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography.
PubMed:
Antihyperuricemic lignans from the leaves of Phyllanthus niruri.
PubMed:
High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus.
PubMed:
Comparative pharmacognostic studies of three Phyllanthus species.
PubMed:
Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus.
PubMed:
Effect of cadmium on growth, ultramorphology of leaf and secondary metabolites of Phyllanthus amarus Schum. and Thonn.
PubMed:
1H- and 13C-nmr assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells.
PubMed:
Antihepatotoxic principles of Phyllanthus niruri herbs.