hypophyllanthin

naphtho(1,2-d)-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7S,8S,9R)-

CAS: 33676-00-5 C24 H30 O7 MW: 430.49750000

Identification

Namehypophyllanthin
IUPAC(7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole
CAS Number33676-00-5
FDA UNII22ZZ21E33P
Molecular FormulaC24 H30 O7
Molecular Weight430.49750000
MDL NumberMFCD03424459
Nikkaji NumberJ238.475B

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 511.10 °C. @ 760.00 mm Hg (est)
Flash Point 393.00 °F. TCC ( 200.80 °C. ) (est)
logP (o/w) 3.770 (est)
Soluble in water, 0.5452 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for hypophyllanthin usage levels up tonot for fragrance use.
Recommendation for hypophyllanthin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

(7R,8R,9S)-9-(3,4- dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole hypophyllantin naphtho(1,2-d)-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7S,8S,9R)- PubMed: Inhibitory Effects of Standardized Extracts of Phyllanthus amarus and Phyllanthus urinaria and Their Marker Compounds on Phagocytic Activity of Human Neutrophils. PubMed: Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. PubMed: Hepatoprotective activity of Indian Phyllanthus. PubMed: Enhancing hepatoprotective bioactives of phyllanthus amarus through immobilization by growth promoters and media changes. PubMed: Clonal propagation of Phyllanthus amarus: A hepatoprotector. PubMed: Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells. PubMed: Endothelium-independent effects of phyllanthin and hypophyllanthin on vascular tension. PubMed: Recent advances in herbal medicine for treatment of liver diseases. PubMed: Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition. PubMed: Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. PubMed: Chromium-induced changes in ultramorphology and secondary metabolites of Phyllanthus amarus Schum & Thonn. - an hepatoprotective plant. PubMed: Separation and quantification of lignans in Phyllanthus species by a simple chiral densitometric method. PubMed: Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads. PubMed: Determination of four lignans in Phyllanthus niruri L. by a simple high-performance liquid chromatography method with fluorescence detection. PubMed: Analysis of lignans from Phyllanthus niruri L. in plasma using a simple HPLC method with fluorescence detection and its application in a pharmacokinetic study. PubMed: Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography. PubMed: Antihyperuricemic lignans from the leaves of Phyllanthus niruri. PubMed: High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus. PubMed: Comparative pharmacognostic studies of three Phyllanthus species. PubMed: Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus. PubMed: Effect of cadmium on growth, ultramorphology of leaf and secondary metabolites of Phyllanthus amarus Schum. and Thonn. PubMed: 1H- and 13C-nmr assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells. PubMed: Antihepatotoxic principles of Phyllanthus niruri herbs.