3,5-dihydroxy-4-methoxybenzoic acid
3,5-dihydroxy-p-anisic acid
Identification
| Name | 3,5-dihydroxy-4-methoxybenzoic acid |
| IUPAC | 3,5-dihydroxy-4-methoxybenzoic acid |
| CAS Number | 4319-02-2 |
| EINECS | 224-346-9 |
| FDA UNII | 0XW32QVU6J |
| Molecular Formula | C8 H8 O5 |
| Molecular Weight | 184.14776000 |
| MDL Number | MFCD00016521 |
| Nikkaji Number | J205.704B |
| XlogP3 | 1.00 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 423.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | 354.00 °F. TCC ( 179.10 °C. ) (est) |
| logP (o/w) | 0.760 (est) |
| Soluble in | water, 1.229e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 3,5-dihydroxy-4-methoxybenzoic acid usage levels up to | not for fragrance use. |
| Recommendation for 3,5-dihydroxy-4-methoxybenzoic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzoic acid, 3,5-dihydroxy-4-methoxy-
3,5-
dihydroxy-p-anisic acid
3,5-
dihydroxy-para-anisic acid
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Chemical constituents from the roots of Leea thorelii Gagnep.
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[Study on the chemical constituents in the fruit of Harrisonia perforata].
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Antinociceptive properties of bergenin.
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Identification of two polyphenolic compounds with antioxidant activities in longan pericarp tissues.
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Acute effects of tea on fasting and non-fasting plasma total homocysteine concentrations in human subjects.
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4-O-methylgallic acid down-regulates endothelial adhesion molecule expression by inhibiting NF-kappaB-DNA-binding activity.
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4-O-Methylgallic acid suppresses inflammation-associated gene expression by inhibition of redox-based NF-kappaB activation.
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Drinking tea is associated with lower plasma total homocysteine in older women.
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Is reversal of endothelial dysfunction by tea related to flavonoid metabolism?
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Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume.
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Two pyranocoumarins from the seeds of Calophyllum polyanthum.
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Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjects.
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Tea intake is inversely related to blood pressure in older women.
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Can black tea influence plasma total homocysteine concentrations?
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Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects.
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Regular ingestion of tea does not inhibit in vivo lipid peroxidation in humans.
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Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans.
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Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects.
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Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans.
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Acute effects of ingestion of black and green tea on lipoprotein oxidation.
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Determination of gallic acid and its metabolites in human plasma and urine by high-performance liquid chromatography.
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Rumen involvement in sheep tannic acid metabolism.
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Antimicrobial constituents of Rhus glabra.
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Isolation and cytotoxicity of two new flavonoids from Chrysosplenium grayanum and related flavonols.
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Toxic interaction between narcotic analgesics and inhibitors of catechol-O-methyltransferase.
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