7-hydroxyflavanone
4H-1-benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-phenyl-
Identification
| Name | 7-hydroxyflavanone |
| IUPAC | 7-hydroxy-2-phenyl-2,3-dihydrochromen-4-one |
| CAS Number | 6515-36-2 |
| FDA UNII | CC64495H41 |
| Molecular Formula | C15 H12 O3 |
| Molecular Weight | 240.25824000 |
| MDL Number | MFCD00017487 |
| Nikkaji Number | J502.873F |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 464.30 °C. @ 760.00 mm Hg (est) |
| Flash Point | 358.00 °F. TCC ( 181.20 °C. ) (est) |
| logP (o/w) | 3.490 (est) |
| Soluble in | water, 416.5 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 7-hydroxyflavanone usage levels up to | not for fragrance use. |
| Recommendation for 7-hydroxyflavanone flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
4H-1-
benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-phenyl-
7-
hydroxy-2-phenyl-2,3-dihydrochromen-4-one
PubMed:
The effect of Zuccagnia punctata, an Argentine medicinal plant, on virulence factors from candida species.
PubMed:
Molecular docking and 3D-QSAR-based virtual screening of flavonoids as potential aromatase inhibitors against estrogen-dependent breast cancer.
PubMed:
Regiospecificity of human UDP-glucuronosyltransferase isoforms in chalcone and flavanone glucuronidation determined by metal complexation and tandem mass spectrometry.
PubMed:
Effects of Zuccagnia punctata extracts and their flavonoids on the function and expression of ABCB1/P-glycoprotein multidrug transporter.
PubMed:
Bioconversion of 7-hydroxyflavanone: isolation, characterization and bioactivity evaluation of twenty-one phase I and phase II microbial metabolites.
PubMed:
Evaluation of novel amylose and cellulose-based chiral stationary phases for the stereoisomer separation of flavanones by means of nano-liquid chromatography.
PubMed:
Microbial transformations of 7-hydroxyflavanone.
PubMed:
Potentiality of standardized extract and isolated flavonoids from Zuccagnia punctata for the treatment of respiratory infections by Streptococcus pneumoniae: in vitro and in vivo studies.
PubMed:
In vitro analysis of iron chelating activity of flavonoids.
PubMed:
20S proteasome inhibitory activity of flavonoids isolated from Spatholobus suberectus.
PubMed:
Comprehensive review of Clerodendrum phlomidis: a traditionally used bitter.
PubMed:
Optical isomer separation of flavanones and flavanone glycosides by nano-liquid chromatography using a phenyl-carbamate-propyl-beta-cyclodextrin chiral stationary phase.
PubMed:
Determination of seven flavonoids in Ixeridium gracile (DC.) Shih by high-performance liquid chromatography.
PubMed:
Singlet oxygen quenching and radical scavenging capacities of structurally-related flavonoids present in Zuccagnia punctata Cav.
PubMed:
Antimetastatic potentials of flavones on oral cancer cell via an inhibition of matrix-degrading proteases.
PubMed:
Synthesis and immunosuppressive activity of L-rhamnopyranosyl flavonoids.
PubMed:
Epoxide formation on the aromatic B ring of flavanone by biphenyl dioxygenase of Pseudomonas pseudoalcaligenes KF707.
PubMed:
Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells.
PubMed:
Phenolic constituents from Dalbergia cochinchinensis.
PubMed:
Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences.
PubMed:
Phytonutrition, phytotherapy, and phytopharmacology.
PubMed:
Actions of some flavonoids on specific and non-specific immune mechanisms.
PubMed:
A chalcone glycoside from Clerodendron phlomidis.
PubMed:
[Microbial kinetics: experiences with Staphylococcus aureus ATCC 25 293 and bacteriostatic drugs].