6-hydroxycoumarin
2H-1-benzopyran-2-one, 6-hydroxy-
Identification
| Name | 6-hydroxycoumarin |
| IUPAC | 6-hydroxychromen-2-one |
| CAS Number | 6093-68-1 |
| FDA UNII | Search |
| Molecular Formula | C9 H6 O3 |
| Molecular Weight | 162.14442000 |
| MDL Number | MFCD00630040 |
| Nikkaji Number | J419.093I |
| XlogP3 | 1.00 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 398.20 °C. @ 760.00 mm Hg (est) |
| Flash Point | 373.00 °F. TCC ( 189.60 °C. ) (est) |
| logP (o/w) | 0.650 (est) |
| Soluble in | water, 3.339e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 6-hydroxycoumarin usage levels up to | not for fragrance use. |
| Recommendation for 6-hydroxycoumarin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2H-1-
benzopyran-2-one, 6-hydroxy-
6-
hydroxy-2H-1-benzopyran-2-one
6-
hydroxychromen-2-one
PubMed:
Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia.
PubMed:
Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents.
PubMed:
RETRACTED: A study of the role of apoptotic cell death and cell cycle events mediating the mechanism of action of 6-hydroxycoumarin-3-carboxylatosilver in human malignant hepatic cells.
PubMed:
Inhibitory effects of 6-alkoxycoumarin and 7-alkoxycoumarin derivatives on lipopolysaccharide/interferon γ-stimulated nitric oxide production in RAW264 cells.
PubMed:
[Coumarins of Anemone raddeana Regel and their biological activity].
PubMed:
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.
PubMed:
[Chemical constituents of an endophytic fungus from Annona muricata].
PubMed:
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.
PubMed:
Antitermite activities of coumarin derivatives and scopoletin from Protium javanicum Burm. f.
PubMed:
Antioxidant constituents from Cotoneaster racemiflora.
PubMed:
Mechanism of action of coumarin and silver(I)-coumarin complexes against the pathogenic yeast Candida albicans.
PubMed:
A study of the role of apoptotic cell death and cell cycle events mediating the mechanism of action of 6-hydroxycoumarin-3-carboxylatosilver in human malignant hepatic cells.
PubMed:
In vitro anti-tumour and cyto-selective effects of coumarin-3-carboxylic acid and three of its hydroxylated derivatives, along with their silver-based complexes, using human epithelial carcinoma cell lines.
PubMed:
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
PubMed:
Coumarins from the heartwoods of Mansonia gagei Drumm.
PubMed:
Cytostatic activity of coumarin metabolites and derivatives in the B16-F10 murine melanoma cell line.