honokiol
3,5'-diallyl-4,2'-dihydroxybiphenyl
Identification
| Name | honokiol |
| IUPAC | 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol |
| CAS Number | 35354-74-6 |
| FDA UNII | 11513CCO0N |
| Molecular Formula | C18 H18 O2 |
| Molecular Weight | 266.33986000 |
| MDL Number | MFCD00016674 |
| Nikkaji Number | J138.358B |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 400.10 °C. @ 760.00 mm Hg (est) |
| Flash Point | 363.00 °F. TCC ( 184.00 °C. ) (est) |
| logP (o/w) | 4.200 (est) |
| Soluble in | water, 1.244 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antioxidants |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for honokiol usage levels up to | not for fragrance use. |
| Recommendation for honokiol flavor usage levels up to | not for flavor use. |
BOC Sciences
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Potential Uses
Natural Occurrence
Synonyms
[1,1'-
biphenyl]-2,4'-diol, 3',5-di-2-propen-1-yl-
3,5'-
diallyl-4,2'-dihydroxybiphenyl
3',5-
diallylbiphenyl-2,4'-diol
2-(4-
hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
PubMed:
Polyethylene glycol-based ultrasound-assisted extraction of magnolol and honokiol from Cortex Magnoliae Officinalis.
PubMed:
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.
PubMed:
Discovery of soluble epoxide hydrolase inhibitors from natural products.
PubMed:
Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice.
PubMed:
Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells.
PubMed:
Honokiol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity.
PubMed:
Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators.
PubMed:
Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis.
PubMed:
Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors.
PubMed:
Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kappaB pathway to reduce LPS-induced TNFalpha and NO expression.
PubMed:
Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed:
Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor.
PubMed:
Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.
PubMed:
[Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
PubMed:
Cytotoxic neolignans: an SAR study.