3,5'-diallyl-4,2'-dihydroxybiphenyl

CAS: 35354-74-6 C18 H18 O2 MW: 266.33986000

Identification

Namehonokiol
IUPAC2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
CAS Number35354-74-6
FDA UNII11513CCO0N
Molecular FormulaC18 H18 O2
Molecular Weight266.33986000
MDL NumberMFCD00016674
Nikkaji NumberJ138.358B

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 400.10 °C. @ 760.00 mm Hg (est)
Flash Point 363.00 °F. TCC ( 184.00 °C. ) (est)
logP (o/w) 4.200 (est)
Soluble in water, 1.244 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for honokiol usage levels up tonot for fragrance use.
Recommendation for honokiol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

magnolia obovata

Synonyms

[1,1'- biphenyl]-2,4'-diol, 3',5-di-2-propen-1-yl- 3,5'- diallyl-4,2'-dihydroxybiphenyl 3',5- diallylbiphenyl-2,4'-diol 2-(4- hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol PubMed: Polyethylene glycol-based ultrasound-assisted extraction of magnolol and honokiol from Cortex Magnoliae Officinalis. PubMed: Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. PubMed: Discovery of soluble epoxide hydrolase inhibitors from natural products. PubMed: Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice. PubMed: Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells. PubMed: Honokiol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity. PubMed: Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators. PubMed: Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis. PubMed: Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors. PubMed: Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kappaB pathway to reduce LPS-induced TNFalpha and NO expression. PubMed: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. PubMed: Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor. PubMed: Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract. PubMed: [Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design]. PubMed: Cytotoxic neolignans: an SAR study.