guggulsterone E

(8R,9S,10R,13S,14S,17E)-17- ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione (E)- guggulsterone E- guggulsterone trans- guggulsterone guggulsterone, (E)- pregna-4,17(20)-diene-3,16-dione, (17E)- PubMed: Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor. PubMed: Reversal of doxorubicin resistance by guggulsterone of Commiphora mukul in vivo. PubMed: Protective Effects of Calycosin Against CCl4-Induced Liver Injury with Activation of FXR and STAT3 in Mice. PubMed: The appetite regulatory effect of guggulsterones in rats: a repertoire of plasma hormones and neurotransmitters. PubMed: Amiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts. PubMed: Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling. PubMed: Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone. PubMed: Guggulsterone of Commiphora mukul resin reverses drug resistance in imatinib-resistant leukemic cells by inhibiting cyclooxygenase-2 and P-glycoprotein. PubMed: Development and Validation of RP-HPLC Method for Simultaneous Estimation of Picroside I, Plumbagin, and Z-guggulsterone in Tablet Formulation. PubMed: [Farnesoid-X-receptor blockade reduces myocardial reperfusion injury in cholesterol-fed apolipoprotein E knockout mice]. PubMed: Guggulsterone regulates the function and expression of P-glycoprotein in rat brain microvessel endothelial cells. PubMed: Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling. PubMed: Targeting beta-catenin signaling to induce apoptosis in human breast cancer cells by z-guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul. PubMed: Guggulsterone attenuates activation and survival of hepatic stellate cell by inhibiting nuclear factor kappa B activation and inducing apoptosis. PubMed: Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: molecular modeling with biological evaluation. PubMed: Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105. PubMed: The guggulsterone derivative GG-52 inhibits NF-κB signaling in bone marrow-derived dendritic cells and attenuates colitis in IL-10 knockout mice. PubMed: Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins. PubMed: Guggulsterone sensitizes glioblastoma cells to Sonic hedgehog inhibitor SANT-1 induced apoptosis in a Ras/NFκB dependent manner. PubMed: Deriving dopaminergic neurons for clinical use. A practical approach. PubMed: Inhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts. PubMed: Proteomic analysis of rosiglitazone and guggulsterone treated 3T3-L1 preadipocytes. PubMed: Cis-guggulsterone inhibits the IKK/NF-κB pathway, whereas trans-guggulsterone inhibits MAPK/AP-1 in MCF‑7 breast cancer cells: guggulsterone regulates MMP‑9 expression in an isomer-specific manner. PubMed: Farnesoid X receptor targeting for hepatitis C: study protocol for a proof-of-concept trial. PubMed: The guggulsterone derivative GG-52 inhibits NF-κB signaling in gastric epithelial cells and ameliorates ethanol-induced gastric mucosal lesions in mice. PubMed: Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis. PubMed: Reversion of P-glycoprotein-mediated multidrug resistance by guggulsterone in multidrug-resistant human cancer cell lines. PubMed: Protective effect of guggulsterone against cardiomyocyte injury induced by doxorubicin in vitro. PubMed: Up-regulation of FXR isoforms is not required for stimulation of the expression of genes involved in the lack of response of colon cancer to chemotherapy. PubMed: Cancer chemopreventive and therapeutic potential of guggulsterone. PubMed: Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression. PubMed: Guggulsterone enhances antitumor activity of gemcitabine in gallbladder cancer cells through suppression of NF-κB. PubMed: Enhanced antitumor effect of combination therapy with gemcitabine and guggulsterone in pancreatic cancer. PubMed: Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition. PubMed: Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii. PubMed: Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump. PubMed: Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone. PubMed: Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target. PubMed: TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells. PubMed: Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress. PubMed: Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts. PubMed: Effective separation and analysis of E- and Z-guggulsterones in Commiphora mukul resin, guggulipid and their pharmaceutical product by high performance thin-layer chromatography-densitometric method. PubMed: Guggulsterone targets smokeless tobacco induced PI3K/Akt pathway in head and neck cancer cells. PubMed: Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion. PubMed: Reversal of multidrug resistance by guggulsterone in drug-resistant MCF-7 cell lines. PubMed: Simultaneous estimation of E- and Z-isomers of guggulsterone in rabbit plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study. PubMed: Guggulsterone-mediated enhancement of radiosensitivity in human tumor cell lines. PubMed: Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-κB and STAT3 pathways in head and neck cancer cells. PubMed: Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma. PubMed: 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells. PubMed: Reactive oxygen species-dependent apoptosis by gugulipid extract of Ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase. PubMed: Guggulsterone suppresses LPS induced inflammation of human middle ear epithelial cells (HMEEC). PubMed: Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells. PubMed: Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells. PubMed: Overcoming multidrug resistance in human cancer cells by natural compounds. PubMed: Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone. PubMed: Novel guggulsterone derivative GG-52 inhibits NF-kappaB signaling in intestinal epithelial cells and attenuates acute murine colitis. PubMed: Guggullipid derivatives: synthesis and applications. PubMed: Bile acids induce cdx2 expression through the farnesoid x receptor in gastric epithelial cells. PubMed: Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. PubMed: Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. PubMed: Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. PubMed: Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes. PubMed: Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death. PubMed: Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats. PubMed: The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease. PubMed: Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by guggulsterone. PubMed: Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. PubMed: The guggul for chronic diseases: ancient medicine, modern targets. PubMed: Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia. PubMed: Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide. PubMed: Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. PubMed: Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists. PubMed: Guggulsterone: a potent farnesoid X receptor antagonist and its rapidly evolving role as a systemic anticarcinogenic agent. PubMed: Guggulsterone, an anti-inflammatory phytosterol, inhibits tissue factor and arterial thrombosis. PubMed: Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice. PubMed: Enhanced pro-apoptotic and anti-adipogenic effects of genistein plus guggulsterone in 3T3-L1 adipocytes. PubMed: Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. PubMed: Bile acid-stimulated expression of the farnesoid X receptor enhances the immune response in Barrett esophagus. PubMed: Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes. PubMed: Guggulsterone, a plant sterol, inhibits NF-kappaB activation and protects pancreatic beta cells from cytokine toxicity. PubMed: Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1. PubMed: Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells. PubMed: z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. PubMed: Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities. PubMed: Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR. PubMed: Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits. PubMed: Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes. PubMed: Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. PubMed: Bile acids promote the expression of hepatitis C virus in replicon-harboring cells. PubMed: Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice. PubMed: Natural products as a gold mine for arthritis treatment. PubMed: Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. PubMed: Guggulsterone production in cell suspension cultures of the guggul tree, Commiphora wightii, grown in shake-flasks and bioreactors. PubMed: Fungal metabolites of (E)-guggulsterone and their antibacterial and radical-scavenging activities. PubMed: The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism. PubMed: Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis. PubMed: Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro. PubMed: The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. PubMed: The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone. PubMed: Lipids isolated from bone induce the migration of human breast cancer cells. PubMed: Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. PubMed: Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. PubMed: Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. PubMed: Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. PubMed: Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice. PubMed: The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter. PubMed: Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes. PubMed: The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand. PubMed: HPTLC method for guggulsterone. I. Quantitative determination of E- and Z-guggulsterone in herbal extract and pharmaceutical dosage form. PubMed: HPTLC method for guggulsterone. II. Stress degradation studies on guggulsterone. PubMed: Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. PubMed: Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. PubMed: Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. PubMed: The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL. PubMed: A natural product ligand of the oxysterol receptor, liver X receptor. PubMed: Cardioprotective activity of synthetic guggulsterone (E and Z-isomers) in isoproterenol induced myocardial ischemia in rats: A comparative study. PubMed: Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene. PubMed: GUGULIPID: a natural cholesterol-lowering agent. PubMed: Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. PubMed: Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. PubMed: Brine shrimp lethality bioassay of selected Indian medicinal plants. PubMed: Guggulsterone: an old approach to a new problem. PubMed: The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. PubMed: A natural product that lowers cholesterol as an antagonist ligand for FXR. PubMed: Simultaneous determination of E- and Z-guggulsterones in dietary supplements containing Commiphora mukul extract (guggulipid) by liquid chromatography. PubMed: High-performance liquid chromatographic method for fingerprinting and quantitative determination of E- and Z-guggulsterones in Commiphora mukul resin and its products. PubMed: Simultaneous determination of the stereoisomers of guggulsterone in serum by high-performance liquid chromatography. PubMed: Microbial transformations of hypolipemic E-guggulsterone. PubMed: A study of effect of guggulsterone on hyperlipidemia of secondary glomerulopathy. PubMed: Sensitive high-performance liquid chromatographic assay method for the determination of guggulsterone in serum. PubMed: Nodulocystic acne: oral gugulipid versus tetracycline. PubMed: Stimulation of low density lipoprotein receptor activity in liver membrane of guggulsterone treated rats. PubMed: Reversal of changes of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats. PubMed: Cardiac sarcolemma enzymes & liver microsomal cytochrome P450 in isoproterenol treated rats. PubMed: Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action. PubMed: Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora mukul. PubMed: Thyroid stimulating action of Z-guggulsterone obtained from Commiphora mukul.