gossypetin

3,5,7,8,3',4'-hexahydroxyflavone

CAS: 489-35-0 C15 H10 O8 MW: 318.23830000

Identification

Namegossypetin
IUPAC2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one
CAS Number489-35-0
FDA UNIISET4M23ZTM
Molecular FormulaC15 H10 O8
Molecular Weight318.23830000
MDL NumberMFCD00017680
Nikkaji NumberJ94.551J

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 679.30 °C. @ 760.00 mm Hg (est)
Flash Point 501.00 °F. TCC ( 260.60 °C. ) (est)
logP (o/w) 1.160 (est)
Soluble in water, 5119 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for gossypetin usage levels up tonot for fragrance use.
Recommendation for gossypetin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

articulatidin 4H-1- benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy- 2-(3,4- dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one equisporol 3,5,7,8,3',4'- hexahydroxyflavone PubMed: Protective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats. PubMed: Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study. PubMed: Antiartherosclerotic effects of plant flavonoids. PubMed: [Chemical constituents of leaves of Psidium guajava]. PubMed: Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation. PubMed: LC-NMR, NMR, and LC-MS identification and LC-DAD quantification of flavonoids and ellagic acid derivatives in Drosera peltata. PubMed: Gossypetin, a naturally occurring hexahydroxy flavone, ameliorates gamma radiation-mediated DNA damage. PubMed: A critical evaluation on the reliability of two aluminum chloride chelation methods for quantification of flavonoids. PubMed: [Study on chemical constituents of Drosera peltata var. multisepala]. PubMed: Flavonoid constituents and free radical scavenging activity of Alchemilla mollis. PubMed: [Metabolites in rat urine after orally administrating gossypetin-8-O-beta-D-glucuronide]. PubMed: Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. PubMed: Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding. PubMed: Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. PubMed: Comparative analysis of flavonoid profile, antioxidant and antimicrobial activity of the berries of Juniperus communis L. var. communis and Juniperus communis L. var. saxatilis Pall. from Turkey. PubMed: Metabolism of hibifolin by human intestinal bacteria. PubMed: Chemodiversity of exudate flavonoids in Cassinia and Ozothamnus (Asteraceae, Gnaphalieae). PubMed: Screening of herbal constituents for aromatase inhibitory activity. PubMed: Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells. PubMed: Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry. PubMed: Anti-oxidant constituents from Sedum takesimense. PubMed: Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. PubMed: Bioactive compounds from Rhodiola rosea (Crassulaceae). PubMed: Antioxidant phenolic constituents from Fagopyrum dibotrys. PubMed: Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. PubMed: Polyoxygenated flavonoids from Eugenia edulis. PubMed: Electrospray mass spectrometric decomposition of some glucuronic acid-containing flavonoid diglycosides. PubMed: Chemical constituents of Pyrrosia petiolosa. PubMed: New erythroxane-type diterpenoids from Fagonia boveana (Hadidi) Hadidi & Graf. PubMed: A novel flavonol lyxoside of Orostachys japonicus herb. PubMed: UDP-glucose: flavonol 7-O-glucosyltransferase activity in flower extracts of Chrysanthemum segetum. PubMed: Bioactive constituents of Chinese natural medicines. II. Rhodiolae radix. (1). Chemical structures and antiallergic activity of rhodiocyanosides A and B from the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey. (Crassulaceae). PubMed: Rhodiocyanosides A and B, new antiallergic cyanoglycosides from Chinese natural medicine "si lie hong jing tian", the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey. PubMed: Dietary flavonoids in atherosclerosis prevention. PubMed: The modification of low density lipoprotein by the flavonoids myricetin and gossypetin. PubMed: Evaluation of flavonoids inGossypium arboreum (L.) cottons as potential source of resistance to tobacco budworm. PubMed: Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. PubMed: Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages. PubMed: Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs. PubMed: Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine. PubMed: Loss of plasmid linked antibiotic resistance in Escherichia coli on treatment with some phenolic compounds. PubMed: C18 solid-phase isolation and high-performance liquid chromatography/ultraviolet diode array determination of fully methoxylated flavones in citrus juices. PubMed: Flavonoids from Picnomon acarna.