ginsenoside Rh1

beta-D-glucopyranoside, (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl

CAS: 63223-86-9 C36 H62 O9 MW: 638.88294000

Identification

Nameginsenoside Rh1
CAS Number63223-86-9
FDA UNIIXBR6F7G8FU
Molecular FormulaC36 H62 O9
Molecular Weight638.88294000
MDL NumberMFCD09951797

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 755.10 °C. @ 760.00 mm Hg (est)
Flash Point 771.00 °F. TCC ( 410.50 °C. ) (est)
logP (o/w) 3.740 (est)
Soluble in water, 0.07331 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for ginsenoside Rh1 usage levels up tonot for fragrance use.
Recommendation for ginsenoside Rh1 flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

ginsenoside RH1 beta-D- glucopyranoside, (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl PubMed: Cloning and heterologous expression of UDP-glycosyltransferase genes from Bacillus subtilis and its application in the glycosylation of ginsenoside Rh1. PubMed: Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells. PubMed: Ginsenoside Rh1 induces mouse osteoblast growth and differentiation through the bone morphogenetic protein 2/runt-related gene 2 signalling pathway. PubMed: Characterization of β-xylosidase from Thermoanaerobacterium thermosaccharolyticum and its application to the production of ginsenosides Rg1 and Rh 1 from notoginsenosides R 1 and R 2. PubMed: Ginsenoside Rb1 eliminates HIV-1 (D3)-transduced cytoprotective human macrophages by inhibiting the AKT pathway. PubMed: Ginsenoside Rh1 potentiates dexamethasone's anti-inflammatory effects for chronic inflammatory disease by reversing dexamethasone-induced resistance. PubMed: [Chemical constituents from processed rhizomes of Panax notoginseng]. PubMed: Quality characteristics and ginsenosides composition of ginseng-yakju according to the particle size of ginseng powder. PubMed: Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus. PubMed: Ginsenoside Rh1 eliminates the cytoprotective phenotype of human immunodeficiency virus type 1-transduced human macrophages by inhibiting the phosphorylation of pyruvate dehydrogenase lipoamide kinase isozyme 1. PubMed: Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells. PubMed: Comparative pharmacokinetics of timosaponin B-II and timosaponin A-III after oral administration of Zhimu-Baihe herb-pair, Zhimu extract, free timosaponin B-II and free timosaponin A-III to rats. PubMed: Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation. PubMed: Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). PubMed: Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice. PubMed: Effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats. PubMed: Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells. PubMed: Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant β-glucosidase. PubMed: Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng. PubMed: Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans. PubMed: Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. PubMed: [Chemical constituents of Chinese red ginseng]. PubMed: Oral administration of ginsenoside Rh1 inhibits the development of atopic dermatitis-like skin lesions induced by oxazolone in hairless mice. PubMed: [Raman spectroscopy study on the interaction of ginsenoside Rb1 with DPPC bilayers]. PubMed: Post-exposure treatment with ginsenoside compound K ameliorates auditory functional injury associated with noise-induced hearing loss in mice. PubMed: Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A pathway and hemeoxygenase-1 expression. PubMed: [Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats]. PubMed: Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship. PubMed: Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-gamma-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways. PubMed: [Determination and enzymolysis preparation of ginsenoside Rh1]. PubMed: Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense. PubMed: [Metabolic study of ginsenoside Re in rats]. PubMed: Biotransformation of ginsenoside Rf to Rh1 by recombinant beta-glucosidase. PubMed: Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol. PubMed: Characterization of pharmacokinetic profiles and metabolic pathways of 20(S)-ginsenoside Rh1 in vivo and in vitro. PubMed: [A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng]. PubMed: Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study. PubMed: Protective effect of ginsenosides Rg(2) and Rh(1) on oxidation-induced impairment of erythrocyte membrane properties. PubMed: Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography. PubMed: Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. PubMed: Screening of anti-platelet aggregation agents from Panax notoginseng using human platelet extraction and HPLC-DAD-ESI-MS/MS. PubMed: [Studies on chemical constituents from rhizomes of Panax notoginseng]. PubMed: Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea. PubMed: An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. PubMed: The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models. PubMed: Influence of ginsenoside Rh1 and F1 on human cytochrome p450 enzymes. PubMed: Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect. PubMed: Simultaneous rapid quantification of ginsenoside Rg1 and its secondary glycoside Rh1 and aglycone protopanaxatriol in rat plasma by liquid chromatography-mass spectrometry after solid-phase extraction. PubMed: [Isolation and identification of minor bioactive saponins from the leaves of Panax notoginseng]. PubMed: Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. PubMed: Degradation of ginsenosides in humans after oral administration. PubMed: A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. PubMed: Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture. PubMed: Enzymatic preparation of ginsenosides Rg2, Rh1, and F1. PubMed: [Saponins with low sugar chain from the leaves of Panax notoginseng (Burk) F. H. Chen]. PubMed: Purification and characterization of ginsenoside-alpha-L-rhamnosidase. PubMed: Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. PubMed: In vitro anti-Helicobacter pylori activity of panaxytriol isolated from ginseng. PubMed: Metabolism of ginsenoside Rg1 by intestinal bacteria. II. Immunological activity of ginsenoside Rg1 and Rh1. PubMed: Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. PubMed: Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1. PubMed: Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2. PubMed: Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng. PubMed: Ginsenosides increase secretion of lipoprotein lipase by 3T3-L1 adipocytes. PubMed: Ginsenoside-Rh1 and Rh2 inhibit the induction of nitric oxide synthesis in murine peritoneal macrophages. PubMed: Determination of aglycones of ginsenosides in ginseng preparations sold in Sweden and in urine samples from Swedish athletes consuming ginseng. PubMed: Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. Collected in central Vietnam. I. PubMed: Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides.