ginsenoside Rg2
beta-D-glucopyranoside, (3-beta,6-alpha,12-beta)-3,12,20-trihydroxydammar-24-en-6-yl-2-o-(6-deoxy-alpha-l-mannopyranosyl)-
Identification
| Name | ginsenoside Rg2 |
| CAS Number | 52286-74-5 |
| FDA UNII | 5R89LAS235 |
| Molecular Formula | C42 H72 O13 |
| Molecular Weight | 785.02544000 |
| MDL Number | MFCD00210511 |
| Beilstein | 6627213 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 889.60 °C. @ 760.00 mm Hg (est) |
| Flash Point | 917.00 °F. TCC ( 491.80 °C. ) (est) |
| logP (o/w) | 6.830 (est) |
| Soluble in | water, 0.06564 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 1340 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for ginsenoside Rg2 usage levels up to | not for fragrance use. |
| Recommendation for ginsenoside Rg2 flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
chikusetsusaponin I
beta-D-
glucopyranoside, (3-beta,6-alpha,12-beta)-3,12,20-trihydroxydammar-24-en-6-yl-2-o-(6-deoxy-alpha-l-mannopyranosyl)-
prosapogenin C2
(6)-(alpha-L-
rhamnopyranosyl(1-rham-2-glu)-beta-D-glucopyranosyl)-20S-protopanaxatriol
PubMed:
Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3.
PubMed:
Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells.
PubMed:
Simultaneous determination of timosaponin B-II and A-III in rat plasma by LC-MS/MS and its application to pharmacokinetic study.
PubMed:
Identification and characterization of a ginsenoside-transforming β-glucosidase from Pseudonocardia sp. Gsoil 1536 and its application for enhanced production of minor ginsenoside Rg2(S).
PubMed:
[Chemical constituents from processed rhizomes of Panax notoginseng].
PubMed:
[Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province].
PubMed:
Changes in ginsenoside composition of ginseng berry extracts after a microwave and vinegar process.
PubMed:
[Quality variation and ecotype division of Panax quinquefolium in China].
PubMed:
A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2.
PubMed:
Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell.
PubMed:
[Screening of pregnane X receptor activation from ginsenosides].
PubMed:
Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus).
PubMed:
State-of-the-art separation of ginsenosides from Korean white and red ginseng by countercurrent chromatography.
PubMed:
Metabolite profiling of ginsenoside Re in rat urine and faeces after oral administration.
PubMed:
Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant β-glucosidase.
PubMed:
Changes in the Contents of Prosapogenin in the Red Ginseng (Panax ginseng) Depending on Steaming Batches.
PubMed:
Protective effects of Rg2 on hypoxia-induced neuronal damage in hippocampal neurons.
PubMed:
Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells.
PubMed:
[Chemical constituents of Chinese red ginseng].
PubMed:
Effects of ginsenoside Rg2 on the ultraviolet B-induced DNA damage responses in HaCaT cells.
PubMed:
Panajaponin, a new glycosphingolipid from Panax japonicus.
PubMed:
Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense.
PubMed:
[Metabolic study of ginsenoside Re in rats].
PubMed:
[Study on excretion of ginsenoside Rg2 in rats].
PubMed:
Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography.
PubMed:
[Effects of 3 genosides on bio-thermodynamic expression of splenic lymphocyte in mice].
PubMed:
Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia.
PubMed:
Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.
PubMed:
Effects of mRg2, a mixture of ginsenosides containing 60% Rg2, on the ultraviolet B-induced DNA repair synthesis and apoptosis in NIH3T3 cells.
PubMed:
Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells.
PubMed:
Simultaneous enantiomer determination of 20 (R)- and 20 (S)-ginsenoside-Rg2 in rat plasma after intravenous administration using HPLC method.
PubMed:
Extraction of 20(S)-ginsenoside Rg2 from cultured Panax notoginseng cells in vitro stimulates human umbilical cord vein endothelial cell proliferation.
PubMed:
[Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats].
PubMed:
Differential effect of ginsenoside metabolites on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.
PubMed:
[Study on the chemical constituents of the roots of commercial ginseng].
PubMed:
Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes.
PubMed:
[Effect of Rg2 on hemodynamics of hemorrhagic shock and its antioxidation in dogs].
PubMed:
Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture.
PubMed:
Enzymatic preparation of ginsenosides Rg2, Rh1, and F1.
PubMed:
Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.
PubMed:
[Practical optimization of the two-dimensional thin-layer chromatographic separation of ginsenosides].
PubMed:
Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors.
PubMed:
Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes.
PubMed:
Purification and characterization of ginsenoside-alpha-L-rhamnosidase.
PubMed:
Characterization of ginseng saponin ginsenoside-Rg(3) inhibition of catecholamine secretion in bovine adrenal chromaffin cells.
PubMed:
Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.
PubMed:
Enzymatic synthesis of two ginsenoside Re-beta-xylosides.
PubMed:
Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1.
PubMed:
Preparation of monoclonal antibody against ginsenoside Rf and its enzyme immunoassay.
PubMed:
Effects of ginseng saponins on responses induced by various receptor stimuli.
PubMed:
Determination of ginsenoside Rf and Rg2 from Panax ginseng using enzyme immunoassay.
PubMed:
Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells.
PubMed:
Inhibition of in vitro tumor cell invasion by ginsenoside Rg3.
PubMed:
Ginseng saponins reduce acetylcholine-evoked Na+ influx and catecholamine secretion in bovine adrenal chromaffin cells.
PubMed:
Effect of 20(S)-ginsenoside-Rg2 and cyproheptadine on two-way active avoidance learning and memory in rats.
PubMed:
[Separation of 20(S)-ginsenoside-Rg2 and its 20(R) epimer by reversed phase low pressure column (Rp-18) chromatography].
PubMed:
[Dammarane-type saponins in leaves of Panax collected in Sichuan].
PubMed:
Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng.
PubMed:
[Isolation and identification of saponin IV, V, VI and VII in ginseng stems].
PubMed:
[Rhizoma ginseng (III)--Isolation and identification of saponins E1 and E2].
PubMed:
Stimulation of the lipogenic pathway in ginsenoside-Rb2 treated rats.
PubMed:
Isolation and characterization of ginsenoside-Rg2, 20R-prosapogenin, 20S-prosapogenin and delta 20-prosapogenin. Chemical studies on saponins of Panax ginseng C. A. Meyer, Third report.