ginsenoside Rg1

(3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diyl bis-beta-D-Glucopyranoside

CAS: 22427-39-0 C42 H72 O14 MW: 801.02464000

Identification

Nameginsenoside Rg1
CAS Number22427-39-0
EINECS244-989-9
FDA UNIIPJ788634QY
Molecular FormulaC42 H72 O14
Molecular Weight801.02464000
MDL NumberMFCD00210293

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 902.70 °C. @ 760.00 mm Hg (est)
Flash Point 931.00 °F. TCC ( 499.70 °C. ) (est)
logP (o/w) 1.670 (est)
Soluble in water, 0.5742 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral Toxicityintraperitoneal-mouse LD50 405 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for ginsenoside Rg1 usage levels up tonot for fragrance use.
Recommendation for ginsenoside Rg1 flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

ginseng

Synonyms

(3beta,6alpha,12beta)-3,12- dihydroxydammar-24-ene-6,20-diyl bis-beta-D-Glucopyranoside (3beta,6alpha,12beta)-3,12- dihydroxydammar-24-ene-6,20-diylbis(beta-D-glucopyranoside) ginsenoside A2 ginsenoside RG1 beta-D- glucopyranoside, (3beta,6alpha,12beta)-3,12-dihydroxy dammar-24-ene-6,20-diylbis- beta-D- glucopyranoside, (3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diyl bis- (6)-beta-D- glucopyranosyl-(20)-beta-D-glucopyranosyl-20S-protopanaxatriol panaxoside A panaxoside Rg1 sanchinoside C1 sanchinoside Rg1 PubMed: Bioconversion of ginsenosides in the american ginseng ( xī yáng shēn) extraction residue by fermentation with lingzhi ( líng zhī, ganoderma lucidum). PubMed: Subacute oral toxicity study of korean red ginseng extract in sprague-dawley rats. PubMed: Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters. PubMed: Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats. PubMed: Biotransformation of ginsenoside Rd in the ginseng extraction residue by fermentation with lingzhi (Ganoderma lucidum). PubMed: Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides. PubMed: A novel strategy with standardized reference extract qualification and single compound quantitative evaluation for quality control of Panax notoginseng used as a functional food. PubMed: The effect of extrusion conditions on the acidic polysaccharide, ginsenoside contents and antioxidant properties of extruded Korean red ginseng. PubMed: [Effect of inorganic fertilizer on quality of Panax ginseng]. PubMed: Metabolite profiling of ginsenoside Re in rat urine and faeces after oral administration. PubMed: Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats. PubMed: Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen. PubMed: Porosity changes and retention of ginsenosides in North American ginseng root using different dehydration processes. PubMed: Study on the interactions between ginsenosides and lysozyme under acidic condition by ESI-MS and molecular docking. PubMed: Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3T3-L1 adipocytes. PubMed: [Microorganisms of special herb-glycosidases and their fermentation, enzyme properties]. PubMed: Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol. PubMed: Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways. PubMed: Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression. PubMed: Effects of ginsenoside Rg1 on postimplantation rat and mouse embryos cultured in vitro. PubMed: Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography. PubMed: Hypothalamic neuronal histamine modulates adaptive behavior and thermogenesis in response to endogenous pyrogen. PubMed: Ginsenoside Rg1 modulates ingestive behavior and thermal response induced by interleukin-1 beta in rats. PubMed: [Study on the nootropic mechanism of ginsenoside Rb1 and Rg1--influence on mouse brain development]. PubMed: Ginsenoside Rg1 prevents histaminergic modulation of rat adaptive behavior from elevation of ambient temperature. PubMed: Attenuation of anorexia induced by heat or surgery during sustained administration of ginsenoside Rg1 into rat third ventricle.