ginsenoside Rc

20-((6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside

CAS: 11021-14-0 C53 H90 O22 MW: 1079.28270000

Identification

Nameginsenoside Rc
CAS Number11021-14-0
EINECS234-253-5
FDA UNII0K83B0L786
Molecular FormulaC53 H90 O22
Molecular Weight1079.28270000
MDL NumberMFCD00133368
Beilstein1677618

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 1128.30 °C. @ 760.00 mm Hg (est)
Flash Point 1177.00 °F. TCC ( 636.20 °C. ) (est)
logP (o/w) 5.100 (est)
Soluble in water, 0.3637 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 410 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for ginsenoside Rc usage levels up tonot for fragrance use.
Recommendation for ginsenoside Rc flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

ginseng

Synonyms

20-((6-O-alpha-L- arabinofuranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside ginsenoside RC panaxoside Rc panaxoside RC PubMed: [Screening active components in compound danshen based on PXR-CYP3A4: an experimental study]. PubMed: Characterization of a ginsenoside-transforming β-glucosidase from Paenibacillus mucilaginosus and its application for enhanced production of minor ginsenoside F₂. PubMed: Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters. PubMed: Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation. PubMed: [Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province]. PubMed: Hydrophilic interaction chromatography for selective separation of isomeric saponins. PubMed: Pharmacokinetic study of ginsenoside Rc and simultaneous determination of its metabolites in rats using RRLC-Q-TOF-MS. PubMed: Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress. PubMed: Mass production of the ginsenoside Rg3(S) through the combinative use of two glycoside hydrolases. PubMed: Complete conversion of major protopanaxadiol ginsenosides to compound K by the combined use of α-L-arabinofuranosidase and β-galactosidase from Caldicellulosiruptor saccharolyticus and β-glucosidase from Sulfolobus acidocaldarius. PubMed: Production of ginsenoside Rd from ginsenoside Rc by α-L-arabinofuranosidase from Caldicellulosiruptor saccharolyticus. PubMed: Diversity of endophytic fungi from roots of Panax ginseng and their saponin yield capacities. PubMed: Determination of ginsenoside Rc in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. PubMed: Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). PubMed: Lactobacillus ginsenosidimutans sp. nov., isolated from kimchi with the ability to transform ginsenosides. PubMed: Four new triterpenoid saponins from the leaves of Panax japonicus grown in southern Miyazaki Prefecture (4). PubMed: Bioconversion of ginsenoside Rc into Rd by a novel α-L-arabinofuranosidase, Abf22-3 from Leuconostoc sp. 22-3: cloning, expression, and enzyme characterization. PubMed: [Identification of major components of traditional Chinese medicine Naodesheng tablet by HPLC-DAD-MS(n)]. PubMed: New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1). PubMed: Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. PubMed: Characterization of a novel ginsenoside-hydrolyzing α-L-arabinofuranosidase, AbfA, from Rhodanobacter ginsenosidimutans Gsoil 3054T. PubMed: Effects of natural products on the function of human organic anion transporting polypeptide 1B1. PubMed: Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans. PubMed: Cloning and characterization of α-L-arabinofuranosidase and bifunctional α-L-arabinopyranosidase/β-D-galactopyranosidase from Bifidobacterium longum H-1. PubMed: Differentiation of Panax quinquefolius grown in the USA and China using LC/MS-based chromatographic fingerprinting and chemometric approaches. PubMed: Microbial transformation of ginsenosides Rb1, Rb3 and Rc by Fusarium sacchari. PubMed: Effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: role of mitogen-activated protein kinases and Akt. PubMed: Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism. PubMed: Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense. PubMed: [Comparative studies on the amount of ginsenosides between the crown galls and Chinese medicinal materials of Panax quinquefolium]. PubMed: Saponins from the processed rhizomes of Polygonatum kingianum. PubMed: [A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng]. PubMed: Effects of extrusion process variables on extractable ginsenosides in wheat-ginseng extrudates. PubMed: Ginsenoside compound K production from ginseng root extract by a thermostable beta-glycosidase from Sulfolobus solfataricus. PubMed: Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans. PubMed: Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD. PubMed: Identification and differentiation of Panax species using ELISA, RAPD and eastern blotting. PubMed: Ginsenoside extraction from Panax quinquefolium L. (American ginseng) root by using ultrahigh pressure. PubMed: Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms. PubMed: [The effect of preparation method on the quality of shen-mai injection]. PubMed: Chromatographic resolution of glucosidic compounds, ginsenosides on polyethersulphone membrane, and its application to the quantitative immunoassay for ginseng saponins. PubMed: Embryotoxicity study of ginsenoside Rc and Re in in vitro rat whole embryo culture. PubMed: Determination of ginsenosides Rb1, Rc, and Re in different dosage forms of ginseng by negative ion electrospray liquid chromatography-mass spectrometry. PubMed: Purification and characterization of alpha-L-arabinopyranosidase and alpha-L-arabinofuranosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium metabolizing ginsenoside Rb2 and Rc. PubMed: Modulation of G protein alpha-subunit mRNA levels in discrete rat brain regions by cerebroventricular infusion of ginsenoside Rc and Rg1. PubMed: Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells. PubMed: Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes. PubMed: Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity. PubMed: Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes. PubMed: Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. PubMed: Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1. PubMed: In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists. PubMed: Effects of Ginsenoside Rb2 and Rc on inferior human sperm motility in vitro. PubMed: Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions. PubMed: Ginsenoside Rc and Rg1 differentially modulate NMDA receptor subunit mRNA levels after intracerebroventricular infusion in rats. PubMed: High production of ginsenosides by transformed root cultures of Panax ginseng: effect of basal medium and Agrobacterium rhizogenes strains. PubMed: Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. PubMed: Ginsenosides that produce differential antinociception in mice. PubMed: Formation of monoclonal antibody against a major ginseng component, ginsenoside Rb1 and its characterization. PubMed: Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. PubMed: Saponins from Vietnamese Ginseng, Panax vietnamensis HA et Grushv. Collected in central Vietnam. II. PubMed: Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors. PubMed: [Saponins in fruits pedicels of Panax notoginseng (Burk.). F.H. Chen]. PubMed: Specific interaction of arabinose residue in ginsenoside with egg phosphatidylcholine vesicles. PubMed: Effect of ginsenosides Rg1, Rc and Rb2 on hormone-induced lipolysis and lipogenesis in rat epididymal fat cells. PubMed: Saponins can cause the agglutination of phospholipid vesicles. PubMed: [Chemical constituents of flower-buds of Panax ginseng--isolation and identification of ginsenoside-Rb3 and ginsenoside-Rc].