ginsenoside Rb1
beta-D-glucopyranoside, (3-beta,12-beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-
Identification
| Name | ginsenoside Rb1 |
| CAS Number | 41753-43-9 |
| EINECS | 255-532-8 |
| FDA UNII | Search |
| Molecular Formula | C54 H92 O23 |
| Molecular Weight | 1109.30884000 |
| MDL Number | MFCD00133367 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 1145.90 °C. @ 760.00 mm Hg (est) |
| Flash Point | 1196.00 °F. TCC ( 646.80 °C. ) (est) |
| logP (o/w) | 2.900 (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 1110 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for ginsenoside Rb1 usage levels up to | not for fragrance use. |
| Recommendation for ginsenoside Rb1 flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
arasaponin E1
pseudo
ginsenoside D
ginsenoside RB1
beta-D-
glucopyranoside, (3-beta,12-beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-
2-O-beta-
glucopyranosyl-(3beta,12beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl-beta-d-glucopyranoside
gynosaponin C
gypenoside III
panax saponin E
sanchinoside E1
PubMed:
Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles.
PubMed:
Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway.
PubMed:
The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation.
PubMed:
Ginsenoside Rb1 eliminates HIV-1 (D3)-transduced cytoprotective human macrophages by inhibiting the AKT pathway.
PubMed:
A well-refined in vitro model derived from human embryonic stem cell for screening phytochemicals with midbrain dopaminergic differentiation-boosting potential for improving Parkinson's disease.
PubMed:
Ginsenoside Rb1 improves energy metabolism in the skeletal muscle of an animal model of postoperative fatigue syndrome.
PubMed:
Expression of antiviral cytokines in Crandell-Reese feline kidney cells pretreated with Korean red ginseng extract or ginsenosides.
PubMed:
Protective effects of ginsenoside Rb1 on septic rats and its mechanism.
PubMed:
[Major hypoglycemic ingredients of panax notoginseng saponins for treating diabetes].
PubMed:
Subacute oral toxicity study of korean red ginseng extract in sprague-dawley rats.
PubMed:
Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3.
PubMed:
Characterization of a ginsenoside-transforming β-glucosidase from Paenibacillus mucilaginosus and its application for enhanced production of minor ginsenoside Fâ.
PubMed:
Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters.
PubMed:
Ginsenoside rb1 modulates level of monoamine neurotransmitters in mice frontal cortex and cerebellum in response to immobilization stress.
PubMed:
Red ginseng protects against gentamicin-induced balance dysfunction and hearing loss in rats through antiapoptotic functions of ginsenoside Rb1.
PubMed:
Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides.
PubMed:
Ginseng panaxoside Rb1 reduces body weight in diet-induced obese mice.
PubMed:
Microbial transformation of ginsenoside Rb1 to compound K by Lactobacillus paralimentarius.
PubMed:
Lactobacillus ginsenosidimutans sp. nov., isolated from kimchi with the ability to transform ginsenosides.
PubMed:
Ginsenosides Rbâ and Rd regulate proliferation of mature keratinocytes through induction of p63 expression in hair follicles.
PubMed:
Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages.
PubMed:
Highly selective microbial transformation of major ginsenoside Rb1 to gypenoside LXXV by Esteya vermicola CNU120806.
PubMed:
Enzymatic biotransformation of ginsenoside Rb1 to compound K by recombinant β-glucosidase from Microbacterium esteraromaticum.
PubMed:
Ginsenoside Rb1 inhibits osteoclastogenesis by modulating NF-κB and MAPKs pathways.
PubMed:
Ginsenoside Rb1 inhibits cell activation and liver fibrosis in rat hepatic stellate cells.
PubMed:
Porosity changes and retention of ginsenosides in North American ginseng root using different dehydration processes.
PubMed:
Ginsenoside Rb1 inhibits proliferation and inflammatory responses in rat aortic smooth muscle cells.
PubMed:
Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats.
PubMed:
Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats.
PubMed:
Application of gamma irradiation in ginseng for both photodegradation of pesticide pentachloronitrobenzene and microbial decontamination.
PubMed:
Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice.
PubMed:
Effects of extrusion process variables on extractable ginsenosides in wheat-ginseng extrudates.
PubMed:
Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways.
PubMed:
Optimization of lipase-catalyzed synthesis of ginsenoside Rb1 esters using response surface methodology.
PubMed:
Optimization of ginsenosides hydrolyzing beta-glucosidase production from Aspergillus niger using response surface methodology.
PubMed:
Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.
PubMed:
Eastern blotting and immunoaffinity concentration using monoclonal antibody for ginseng saponins in the field of traditional chinese medicines.
PubMed:
Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium).
PubMed:
Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms.
PubMed:
Determination of ginsenosides Rb1, Rc, and Re in different dosage forms of ginseng by negative ion electrospray liquid chromatography-mass spectrometry.
PubMed:
Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography.
PubMed:
Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew).
PubMed:
[Study on the nootropic mechanism of ginsenoside Rb1 and Rg1--influence on mouse brain development].
PubMed:
[Ginsenoside-Rb1 as a suppressor in central modulation of feeding in the rat].