ginkgolide J
7beta-hydroxyginkgolide A
Identification
| Name | ginkgolide J |
| CAS Number | 107438-79-9 |
| FDA UNII | M5297RI2UE |
| Molecular Formula | C20 H24 O10 |
| Molecular Weight | 424.40328000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 760.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | 524.00 °F. TCC ( 273.60 °C. ) (est) |
| logP (o/w) | -0.680 (est) |
| Soluble in | water, 1.838e+005 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for ginkgolide J usage levels up to | not for fragrance use. |
| Recommendation for ginkgolide J flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
ginkgolide A, 7-hydroxy-, (7beta)-
7beta-
hydroxyginkgolide A
PubMed:
Transport of ginkgolides with different lipophilicities based on an hCMEC/D3 cell monolayer as a blood-brain barrier cell model.
PubMed:
Urinary excretion of ginkgolide terpene lactones following acute consumption of Ginkgo biloba extract.
PubMed:
Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor.
PubMed:
Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.
PubMed:
Selective agonism of human pregnane X receptor by individual ginkgolides.
PubMed:
Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants.
PubMed:
Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.
PubMed:
Development of an alternative method for determination of terpene lactones in ginkgo dry extract.
PubMed:
Optimization of extraction technique and validation of developed RP-HPLC-ELSD method for determination of terpene trilactones in Ginkgo biloba leaves.
PubMed:
Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements.
PubMed:
Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype.
PubMed:
Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J.
PubMed:
Single-laboratory validation for the determination of terpene lactones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography with evaporative light-scattering detection.
PubMed:
Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes.
PubMed:
Ginkgo biloba leaf extract reverses amyloid beta-peptide-induced isoprostane production in rat brain in vitro.
PubMed:
Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.
PubMed:
Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts.
PubMed:
A method for extraction and quantification of Ginkgo terpene trilactones.
PubMed:
Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors.
PubMed:
Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease.
PubMed:
Rapid analysis of terpene lactones in extract of Ginkgo biloba L. by high performance liquid chromatography.
PubMed:
Simultaneous determination of terpene lactones and flavonoid aglycones in Ginkgo biloba by high-performance liquid chromatography with evaporative light scattering detection.
PubMed:
Ginkgolides: selective acetylations, translactonization, and biological evaluation.
PubMed:
Liquid chromatography-atmospheric pressure chemical ionisation/mass spectrometry: a rapid and selective method for the quantitative determination of ginkgolides and bilobalide in ginkgo leaf extracts and phytopharmaceuticals.
PubMed:
Three ginkgolide hydrates from Ginkgo biloba L.: ginkgolide A monohydrate, ginkgolide C sesquihydrate and ginkgolide J dihydrate, all determined at 120 K.
PubMed:
Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents.
PubMed:
Antioxidative activity of ginkgolides against superoxide in an aprotic environment.
PubMed:
Effect of ischaemia and role of eicosanoids in release of atrial natriuretic factor from rat heart.
PubMed:
Separate induction of human blood platelet aggregation or cytotoxicity by different concentrations of PAF-acether and thrombin.
PubMed:
Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney.
PubMed:
The effect of the platelet-activating factor antagonist, BN 52021, on human natural killer cell-mediated cytotoxicity.