ginkgolide J

7beta-hydroxyginkgolide A

CAS: 107438-79-9 C20 H24 O10 MW: 424.40328000

Identification

Nameginkgolide J
CAS Number107438-79-9
FDA UNIIM5297RI2UE
Molecular FormulaC20 H24 O10
Molecular Weight424.40328000

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 760.40 °C. @ 760.00 mm Hg (est)
Flash Point 524.00 °F. TCC ( 273.60 °C. ) (est)
logP (o/w) -0.680 (est)
Soluble in water, 1.838e+005 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for ginkgolide J usage levels up tonot for fragrance use.
Recommendation for ginkgolide J flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

ginkgo biloba

Synonyms

ginkgolide A, 7-hydroxy-, (7beta)- 7beta- hydroxyginkgolide A PubMed: Transport of ginkgolides with different lipophilicities based on an hCMEC/D3 cell monolayer as a blood-brain barrier cell model. PubMed: Urinary excretion of ginkgolide terpene lactones following acute consumption of Ginkgo biloba extract. PubMed: Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor. PubMed: Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba. PubMed: Selective agonism of human pregnane X receptor by individual ginkgolides. PubMed: Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants. PubMed: Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides. PubMed: Development of an alternative method for determination of terpene lactones in ginkgo dry extract. PubMed: Optimization of extraction technique and validation of developed RP-HPLC-ELSD method for determination of terpene trilactones in Ginkgo biloba leaves. PubMed: Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements. PubMed: Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype. PubMed: Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. PubMed: Single-laboratory validation for the determination of terpene lactones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography with evaporative light-scattering detection. PubMed: Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes. PubMed: Ginkgo biloba leaf extract reverses amyloid beta-peptide-induced isoprostane production in rat brain in vitro. PubMed: Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes. PubMed: Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts. PubMed: A method for extraction and quantification of Ginkgo terpene trilactones. PubMed: Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. PubMed: Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. PubMed: Rapid analysis of terpene lactones in extract of Ginkgo biloba L. by high performance liquid chromatography. PubMed: Simultaneous determination of terpene lactones and flavonoid aglycones in Ginkgo biloba by high-performance liquid chromatography with evaporative light scattering detection. PubMed: Ginkgolides: selective acetylations, translactonization, and biological evaluation. PubMed: Liquid chromatography-atmospheric pressure chemical ionisation/mass spectrometry: a rapid and selective method for the quantitative determination of ginkgolides and bilobalide in ginkgo leaf extracts and phytopharmaceuticals. PubMed: Three ginkgolide hydrates from Ginkgo biloba L.: ginkgolide A monohydrate, ginkgolide C sesquihydrate and ginkgolide J dihydrate, all determined at 120 K. PubMed: Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents. PubMed: Antioxidative activity of ginkgolides against superoxide in an aprotic environment. PubMed: Effect of ischaemia and role of eicosanoids in release of atrial natriuretic factor from rat heart. PubMed: Separate induction of human blood platelet aggregation or cytotoxicity by different concentrations of PAF-acether and thrombin. PubMed: Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney. PubMed: The effect of the platelet-activating factor antagonist, BN 52021, on human natural killer cell-mediated cytotoxicity.