fraxetin-8-O-glucoside

CAS: 524-30-1 C16 H18 O10 MW: 370.31146000

Identification

Namefraxin
IUPAC7-hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
CAS Number524-30-1
EINECS208-355-5
FDA UNIIV7M270Y072
Molecular FormulaC16 H18 O10
Molecular Weight370.31146000
MDL NumberMFCD00010093
Nikkaji NumberJ22.598C

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 722.20 °C. @ 760.00 mm Hg (est)
Flash Point 513.00 °F. TCC ( 267.10 °C. ) (est)
logP (o/w) -1.930 (est)
Soluble in water, 1.912e+005 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for fraxin usage levels up tonot for fragrance use.
Recommendation for fraxin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

fraxinus excelsior leaf

Synonyms

2H-1- benzopyran-2-one, 8-(beta-D-glucopyranosyloxy)-7-hydroxy-6-methoxy- fraxetin-8-O-glucoside 8-(beta-D- glucopyranosyloxy)-7-hydroxy-6-methoxy-2h-1-benzopyran-2-one 7- hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one paviin PubMed: Simultaneous Determination of Five Constituents in Qinpijiegu Capsule by High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry. PubMed: Purification of Coumarin Compounds From Cortex fraxinus by Adsorption Chromatography. PubMed: [Quantitative method for simultaneous assay of four coumarins with one marker in Fraxini Cortex]. PubMed: Antioxidative and anti-inflammatory effects of phenolic compounds from the roots of Ulmus macrocarpa. PubMed: Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm. PubMed: Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice. PubMed: Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells. PubMed: A new phenolic compound, 4-dehydrochebulic acid-1,6-dimethyl ester from Sapium insigne leaves. PubMed: [Studies on chemical constituents from stem barks of Fraxinus paxiana]. PubMed: [Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity]. PubMed: Functional analysis of LjSUT4, a vacuolar sucrose transporter from Lotus japonicus. PubMed: Simultaneous analysis of coumarins and secoiridoids in Cortex Fraxini by high-performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry. PubMed: Cytotoxic phenolic constituents of Acer tegmentosum maxim. PubMed: Arabidopsis sucrose transporter AtSUC9. High-affinity transport activity, intragenic control of expression, and early flowering mutant phenotype. PubMed: Metabolic fate of fraxin administered orally to rats. PubMed: Solution to spectroscopy challenge 10. PubMed: Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. PubMed: A new compound from Rhododendren anthopogonosides maxim. PubMed: Analysis and bioactive evaluation of the compounds absorbed into blood after oral administration of the extracts of Vaccinium vitis-idaea in rat. PubMed: Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography. PubMed: Non-aqueous capillary electrophoresis for separation and simultaneous determination of fraxin, esculin and esculetin in Cortex fraxini and its medicinal preparations. PubMed: HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata. PubMed: Effect of organic cosolvents on the stability and activity of the beta-1,4-galactosyltransferase from bovine colostrum. PubMed: Structure-activity relationship of coumarins in xanthine oxidase inhibition. PubMed: Effect of some hydroxycoumarins on complement-mediated hemolysis in human serum. PubMed: Reversed-phase HPTLC densitometric evaluation of fraxin in Fraxinus excelsior leaves. PubMed: Role of sulfate concentration in dechlorination of 3,4,5-trichlorocatechol by stable enrichment cultures grown with coumarin and flavanone glycones and aglycones. PubMed: Semisynthetic transformations of fraxin to biological active compounds. PubMed: Fast atom bombardment and tandem mass spectrometry for structure determination of steroid and flavonoid glycosides. PubMed: Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins.