fraxin
fraxetin-8-O-glucoside
Identification
| Name | fraxin |
| IUPAC | 7-hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one |
| CAS Number | 524-30-1 |
| EINECS | 208-355-5 |
| FDA UNII | V7M270Y072 |
| Molecular Formula | C16 H18 O10 |
| Molecular Weight | 370.31146000 |
| MDL Number | MFCD00010093 |
| Nikkaji Number | J22.598C |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 722.20 °C. @ 760.00 mm Hg (est) |
| Flash Point | 513.00 °F. TCC ( 267.10 °C. ) (est) |
| logP (o/w) | -1.930 (est) |
| Soluble in | water, 1.912e+005 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for fraxin usage levels up to | not for fragrance use. |
| Recommendation for fraxin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2H-1-
benzopyran-2-one, 8-(beta-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-
fraxetin-8-O-glucoside
8-(beta-D-
glucopyranosyloxy)-7-hydroxy-6-methoxy-2h-1-benzopyran-2-one
7-
hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
paviin
PubMed:
Simultaneous Determination of Five Constituents in Qinpijiegu Capsule by High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry.
PubMed:
Purification of Coumarin Compounds From Cortex fraxinus by Adsorption Chromatography.
PubMed:
[Quantitative method for simultaneous assay of four coumarins with one marker in Fraxini Cortex].
PubMed:
Antioxidative and anti-inflammatory effects of phenolic compounds from the roots of Ulmus macrocarpa.
PubMed:
Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.
PubMed:
Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice.
PubMed:
Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells.
PubMed:
A new phenolic compound, 4-dehydrochebulic acid-1,6-dimethyl ester from Sapium insigne leaves.
PubMed:
[Studies on chemical constituents from stem barks of Fraxinus paxiana].
PubMed:
[Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].
PubMed:
Functional analysis of LjSUT4, a vacuolar sucrose transporter from Lotus japonicus.
PubMed:
Simultaneous analysis of coumarins and secoiridoids in Cortex Fraxini by high-performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry.
PubMed:
Cytotoxic phenolic constituents of Acer tegmentosum maxim.
PubMed:
Arabidopsis sucrose transporter AtSUC9. High-affinity transport activity, intragenic control of expression, and early flowering mutant phenotype.
PubMed:
Metabolic fate of fraxin administered orally to rats.
PubMed:
Solution to spectroscopy challenge 10.
PubMed:
Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress.
PubMed:
A new compound from Rhododendren anthopogonosides maxim.
PubMed:
Analysis and bioactive evaluation of the compounds absorbed into blood after oral administration of the extracts of Vaccinium vitis-idaea in rat.
PubMed:
Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography.
PubMed:
Non-aqueous capillary electrophoresis for separation and simultaneous determination of fraxin, esculin and esculetin in Cortex fraxini and its medicinal preparations.
PubMed:
HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata.
PubMed:
Effect of organic cosolvents on the stability and activity of the beta-1,4-galactosyltransferase from bovine colostrum.
PubMed:
Structure-activity relationship of coumarins in xanthine oxidase inhibition.
PubMed:
Effect of some hydroxycoumarins on complement-mediated hemolysis in human serum.
PubMed:
Reversed-phase HPTLC densitometric evaluation of fraxin in Fraxinus excelsior leaves.
PubMed:
Role of sulfate concentration in dechlorination of 3,4,5-trichlorocatechol by stable enrichment cultures grown with coumarin and flavanone glycones and aglycones.
PubMed:
Semisynthetic transformations of fraxin to biological active compounds.
PubMed:
Fast atom bombardment and tandem mass spectrometry for structure determination of steroid and flavonoid glycosides.
PubMed:
Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins.