flavokawain C

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2',4-dihydroxy-4',6'-dimethoxychalcone

CAS: 56798-34-6 C17 H16 O5 MW: 300.31052000
All Ingredients Aromatic Ingredients CAS Numbers Found in Nature

Identification

Nameflavokawain C
IUPAC(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
CAS Number56798-34-6
FDA UNIISearch
Molecular FormulaC17 H16 O5
Molecular Weight300.31052000
MDL NumberMFCD00016489
Nikkaji NumberJ647.134J

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 556.00 °C. @ 760.00 mm Hg (est)
Flash Point 405.00 °F. TCC ( 207.30 °C. ) (est)
logP (o/w) 3.480 (est)
Soluble in water, 36.49 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for flavokawain C usage levels up tonot for fragrance use.
Recommendation for flavokawain C flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

kava

Synonyms

2',4- dihydroxy-4',6'-dimethoxychalcone flavokavain C (2E)-1-(2- hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one (E)-1-(2- hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one 2- propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)- PubMed: Induction of Apoptosis and Cell Cycle Arrest by Flavokawain C on HT-29 Human Colon Adenocarcinoma via Enhancement of Reactive Oxygen Species Generation, Upregulation of p21, p27, and GADD153, and Inactivation of Inhibitor of Apoptosis Proteins. PubMed: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PubMed: Phenols displaying tyrosinase inhibition from Humulus lupulus. PubMed: Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids.