alpha-boswellic acid
olean-12-en-24-oic acid, 3-hydroxy-, (3a)-
Identification
| Name | alpha-boswellic acid |
| IUPAC | (3R,4R,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4-carboxylic acid |
| CAS Number | 471-66-9 |
| FDA UNII | Search |
| Molecular Formula | C30 H48 O3 |
| Molecular Weight | 456.71016000 |
| MDL Number | MFCD03788779 |
| Nikkaji Number | J12.038C |
| Beilstein | 3074442 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 552.70 °C. @ 760.00 mm Hg (est) |
| Flash Point | 576.00 °F. TCC ( 302.10 °C. ) (est) |
| logP (o/w) | 9.430 (est) |
| Soluble in | water, 0.001748 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for alpha-boswellic acid usage levels up to | not for fragrance use. |
| Recommendation for alpha-boswellic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
a-
boswellic acid
(3R,4R,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-3-
hydroxy-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4-carboxylic acid
(3a)-3-
hydroxyolean-12-en-24-oic acid
olean-12-en-24-oic acid, 3-hydroxy-, (3a)-
PubMed:
[Change in dissolution of chemical components of frankincense-myrrh before and after their compatibility and effect on no release of LPS-induced macrophage cells].
PubMed:
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.
PubMed:
Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.
PubMed:
[Determination of five boswellic acids in Boswellia serrata].
PubMed:
Antituberculosis cycloartane triterpenoids from Radermachera boniana.
PubMed:
Two new triterpenoids from the resin of Boswellia carterii.
PubMed:
Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.
PubMed:
A norsesquiterpene lactone and a benzoic acid derivative from the leaves of Cyclocarya paliurus and their glucosidase and glycogen phosphorylase inhibiting activities.
PubMed:
Characterization of 3alpha-acetyl-11-keto-alpha-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo.
PubMed:
Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction.
PubMed:
High-performance liquid chromatographic determination of acetyl-11-keto-alpha-boswellic acid, a novel pentacyclic triterpenoid, in plasma using a fluorinated stationary phase and photodiode array detection: application in pharmacokinetic studies.
PubMed:
Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells.
PubMed:
Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers.
PubMed:
Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-alpha induction in monocytes by direct interaction with IkappaB kinases.
PubMed:
Characterization of archaeological frankincense by gas chromatography-mass spectrometry.
PubMed:
Immunomodulatory triterpenoids from the oleogum resin of Boswellia carterii Birdwood.
PubMed:
[Chemical components of Boswellia carterii].
PubMed:
A lupane triterpene from frankincense (Boswellia sp., Burseraceae).