arecoline hydrobromide

methyl N-methyl-1,2,5,6-tetrahydronicotinate hydrobromide

CAS: 300-08-3 C8 H14 Br N O2 MW: 236.10898000

Identification

Namearecoline hydrobromide
IUPACmethyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide
CAS Number300-08-3
FDA UNII24S79B9CX7
Molecular FormulaC8 H14 Br N O2
Molecular Weight236.10898000
MDL NumberMFCD00039041
Beilstein3914826

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in water, 3.538e+005 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityparenteral-frog LD50 160 mg/kg
Dermal Toxicitysubcutaneous-mouse LDLo 65 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#11778']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for arecoline hydrobromide usage levels up tonot for fragrance use.
Recommendation for arecoline hydrobromide flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

arecoline bromide arekolinhydrobromid methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide methyl 1,2,5,6-tetrahydro-1-methylnicotinate, hydrobromide methyl N-methyl-1,2,5,6-tetrahydronicotinate hydrobromide N- methyltetrahydronicotinic acid methyl ester hydrobromide nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide 3- pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (9CI) taeniolin PubMed: Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry. PubMed: Effects of arecoline on hepatic cytochrome P450 activity and oxidative stress. PubMed: Assessment of the mutagenic potential of arecoline in gpt delta transgenic mice. PubMed: Frequency- and state-dependent blockade of human ether-a-go-go-related gene K+ channel by arecoline hydrobromide. PubMed: Surface plasmon resonance based biosensors for exploring the influence of alkaloids on aggregation of amyloid-β peptide. PubMed: Association constants of pyridine and piperidine alkaloids to amyloid beta peptide determined by electrochemical impedance spectroscopy. PubMed: Echinococcus granulosus and other intestinal helminths in semi-stray dogs in Tunisia: infection and re-infection rates. PubMed: Screening for Echinococcus granulosus in dogs: Comparison between arecoline purgation, coproELISA and coproPCR with necropsy in pre-patent infections. PubMed: Echinococcus granulosus in northern Queensland. 2. Ecological determinants of infection in beef cattle. PubMed: Patent and pre-patent detection of Echinococcus granulosus genotypes in the definitive host. PubMed: Combined use of tertiary amine parasympathomimetics with a quaternary amine parasympatholitic--a new perspective to use parasympathomimetic drugs for systemic analgesia. PubMed: Hydatidosis in the province of La Pampa, Argentina, 1998. PubMed: Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors. PubMed: [Echinococcosis/hydatidosis in the VII Region of Chile: diagnosis and educational intervention]. PubMed: Canine echinococcosis: an alternative for surveillance epidemiology. PubMed: Teratogenicity of arecoline hydrobromide on developing chick embryos: a preliminary report. PubMed: An epidemiological survey of Echinococcus granulosus and other helminths in animal populations in northern Israel. PubMed: Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton. PubMed: Echinococcus granulosus infection of farm dogs of Iran. PubMed: Echinococcus granulosus infections of dogs in the Durazno region of Uruguay. PubMed: Histological preparation of the Echinococcus sp. tapeworms: staining affinity of the adult form. PubMed: The cholinergic rapid eye movement induction test with arecoline in depression. PubMed: Arecoline, but not haloperidol, induces changes in the permeability of the blood-brain barrier in the rat. PubMed: Multiple-dose arecoline infusions in Alzheimer's disease. PubMed: Memory retention test performance in mice: improvement by chronic oral cholinergic drug treatment. PubMed: Autonomic function in cholinergic urticaria and atopic eczema. PubMed: Memory retention: effect of prolonged cholinergic stimulation in mice. PubMed: [Hydatidosis: epidemiological study in the eastern region of the province of Formosa]. PubMed: The toxicity and efficiency of arecoline hydrobromide in the Tasmanian hydatid control program. PubMed: Activity of uredofos, niclosamide, bunamidine hydrochloride, and arecoline hydrobromide against Mesocestoides corti in experimentally infected dogs. PubMed: Prevalence of Echinococcus granulosus and other cestodes in dogs on the Navajo reservation in Arizona and New Mexico. PubMed: Effect of deworming medication on the microbial flora of the upper gastrointestinal tract of dogs. PubMed: Areca nut: a review. PubMed: Comparative value of arecoline hydrobromide and bunamidine hydrochloride for the treatment of Echinococcus granulosus in dogs. PubMed: [A guide to the use of arecoline hydrobromide for the diagnosis of echinococcus granulosus infection in the dog (author's transl)]. PubMed: Surveillance of Echinococcus granulosus in dogs with arecoline hydrobromide. PubMed: The Styx field-trial. A study on the application of control measures against hydatid disease caused by Echinococcus granulosus. PubMed: Evaluation of selected drugs for the treatment of canine echinococcosis. PubMed: THE RELATION BETWEEN METHOD OF ADMINISTRATION, ROUTE OF ABSORPTION, INHIBITORY ACTIONS AND ACUTE TOXICITY OF ARECOLINE HYDROBROMIDE IN DOGS. PubMed: THE USE OF ARECOLINE HYDROBROMIDE IN THE TREATMENT OF TAENIID INFECTIONS IN DOGS. PubMed: Effect of combined arecoline hydrobromide and n-butyl chloride complex on parasites of dogs. PubMed: [Dehelmintization of geese with arecoline hydrobromide]. PubMed: [Effect of vitamin B1 on arecoline hydrobromide in dye shock]. PubMed: [Effect of arecoline hydrobromide on the peripheral blood vessels in rabbits]. PubMed: Testing arecoline hydrobromide as an anthelminthic for hydatid worms in dogs.